Chitosan-based dithiophenolato nanoparticles: Preparation, mechanistic information of DNA binding, antibacterial and cytotoxic activities

Shaban, Nadia Z.; Aboelsaad, Ahmed M.; Shoueir, Kamel R.; Abdulmalek, Shaymaa A.; Awad, Doaa; Shaban, Shaban Y.; Mansour, Hanaa

doi:10.1016/j.molliq.2020.114252

Cited by 34 publications

(27 citation statements)

References 30 publications

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“…For centuries, silver ions (Ag + ) released by silver compounds have been used for hygienic and healing purposes due to their antibacterial, antifungal and antiviral properties [ 32 , 33 ]. They have the capacity to strongly suppress the bacterial growth by inhibiting the respiratory enzyme pathways, restricting the electron transport chain components and directly interfering with DNA [ [34] , [35] , [36] , [37] ]. Compared to the delivery of Ag ions via Ag particles, their delivery as a dopant is anticipated to provide for slower release rates and thus avoid many of the adverse side effects associated with the use of particulate Ag as a biomaterial.…”

Section: Introductionmentioning

confidence: 99%

Nanofibrous ε-polycaprolactone scaffolds containing Ag-doped magnetite nanoparticles: Physicochemical characterization and biological testing for wound dressing applications in vitro and in vivo

Ahmed

Zayed

El-Dek

et al. 2021

Bioactive Materials

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Section: Introductionmentioning

confidence: 99%

Nanofibrous ε-polycaprolactone scaffolds containing Ag-doped magnetite nanoparticles: Physicochemical characterization and biological testing for wound dressing applications in vitro and in vivo

Ahmed

Zayed

El-Dek

et al. 2021

Bioactive Materials

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“…These PNF-GQDs nanohybrids demonstrated the ability to concentrate and visualize cancer cells simultaneously using a sensing component and an imaging test. Furthermore, PNF-GQDs nanohybrids have extraordinary potential, particularly when sensitive traceability and efficient labeling are evaluated [158,159]. GQDs-dependent operator is another photodynamic treatment (PDT), that can produce singlet oxygen through a multi-state refinement method and provide PDT experts with a quantum output of 1.2 with the highest description.…”

Section: Bio Imagesmentioning

confidence: 99%

Outstanding Graphene Quantum Dots from Carbon Source for Biomedical and Corrosion Inhibition Applications: A Review

et al. 2021

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Graphene quantum dots (GQD) is an efficient nanomaterial composed of one or more layers of graphene with unique properties that combine both graphene and carbon dots (CDs). It can be synthesized using carbon-rich materials as precursors, such as graphite, macromolecules polysaccharides, and fullerene. This contribution emphasizes the utilization of GQD-based materials in the fields of sensing, bioimaging, energy storage, and corrosion inhibitors. Inspired by these numerous applications, various synthetic approaches have been developed to design and fabricate GQD, particularly bottom-up and top-down processes. In this context, the prime goal of this review is to emphasize possible eco-friendly and sustainable methodologies that have been successfully employed in the fabrication of GQDs. Furthermore, the fundamental and experimental aspects associated with GQDs such as possible mechanisms, the impact of size, surface alteration, and doping with other elements, together with their technological and industrial applications have been envisaged. Till now, understanding simple photo luminance (PL) operations in GQDs is very critical as well as there are various methods derived from the optical properties of manufactured GQDs can differ. Lack of determining exact size and morphology is highly required without loss of their optical features. Finally, GQDs are promising candidates in the after-mentioned application fields.

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“…DTP-CSNPs were prepared (from DTP, sodium tripolyphosphate (TPP) and chitosan) and characterized as mentioned in our previous paper (Shaban et al 2020). In brief, TPP solution was added to chitosan solution, For the determination of LD50 of DTP or DTP-CSNPs, 48 rats were used after the acclimation period.…”

Section: Preparation Of Dtp-csnpsmentioning

confidence: 99%

Therapeutic Effect of Dithiophenolato Chitosan Nanocomposites Against Carbon Tetrachloride-induced Hepatotoxicity in Rats

Shaban

Aboelsaad

Awad

et al. 2021

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Our previous study showed that dithiophenolate (DTP) and its chitosan nanoparticles (DTP-CSNPs) have abilities to bind with DNA helixes. So in this study, their lethal doses (LD50) and therapeutic roles against rat liver injuries induced by carbon tetrachloride (CCl4) were evaluated. The study focused on the determination of the markers of oxidative stress (OS) and apoptosis and compare the results with those of cisplatin treatment. The results revealed that LD50 values of DTP and DTP-CSNPs are 2187.5 and 1462.5 mg/kg, respectively. Treatment with DPT and DPT-CSNPs after CCl4 administration reduced liver injuries, induced by CCl4, and improved liver functions and architecture through the reduction of OS and apoptosis. Where the oxidant marker was decreased with elevations of antioxidant markers. Also, there was an elevation in Bcl 2 value, with decreases in caspase-8, Bax, and Bax/Bcl 2 ratio. DPT-CSNPs treatment gave preferable results than that treated with DPT. Moreover, DTP and DPT-CSNPs treatment gave better results than Cisplatine treatment. The administration of healthy rats with low doses of DTP and DTP-CSNPs for 14 days had no effect. Otherwise, the study on HepG2 cell line showed that DTP and DPT-CSNPs inhibited cell growth by arresting cells in the G2/M phase and inducing cell death. In conclusion: DTP and DTP-CSNPs have anti-apoptotic and anti-oxidative stress towards hepatotoxicity induced by CCl4. Moreover, DTP and DTP-CSNPs have anticancer activity against the HepG2 cell line. Generally, DTP-CSNPs are more effective than DTP. So, they can be used in the pharmacological fields, especially DTP-CSNPS.

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Chitosan-based dithiophenolato nanoparticles: Preparation, mechanistic information of DNA binding, antibacterial and cytotoxic activities

Cited by 34 publications

References 30 publications

Nanofibrous ε-polycaprolactone scaffolds containing Ag-doped magnetite nanoparticles: Physicochemical characterization and biological testing for wound dressing applications in vitro and in vivo

Nanofibrous ε-polycaprolactone scaffolds containing Ag-doped magnetite nanoparticles: Physicochemical characterization and biological testing for wound dressing applications in vitro and in vivo

Outstanding Graphene Quantum Dots from Carbon Source for Biomedical and Corrosion Inhibition Applications: A Review

Therapeutic Effect of Dithiophenolato Chitosan Nanocomposites Against Carbon Tetrachloride-induced Hepatotoxicity in Rats

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Chitosan-based dithiophenolato nanoparticles: Preparation, mechanistic information of DNA binding, antibacterial and cytotoxic activities

Cited by 34 publications

References 30 publications

Nanofibrous ε-polycaprolactone scaffolds containing Ag-doped magnetite nanoparticles: Physicochemical characterization and biological testing for wound dressing applications in vitro and in vivo

Nanofibrous ε-polycaprolactone scaffolds containing Ag-doped magnetite nanoparticles: Physicochemical characterization and biological testing for wound dressing applications in vitro and in vivo

Outstanding Graphene Quantum Dots from Carbon Source for Biomedical and Corrosion Inhibition Applications: A Review

Therapeutic Effect of&nbsp;Dithiophenolato Chitosan Nanocomposites Against Carbon Tetrachloride-induced Hepatotoxicity in Rats

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Product

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Therapeutic Effect of Dithiophenolato Chitosan Nanocomposites Against Carbon Tetrachloride-induced Hepatotoxicity in Rats