Chitosan-based biomaterials for tissue engineering

Croisier, Florence; Jérôme, Christine

doi:10.1016/j.eurpolymj.2012.12.009

Cited by 1,810 publications

(1,069 citation statements)

References 140 publications

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“…The water contact angles of the nanopatterned and flat adhesives were 95.3 ± 3.4°and 90.0 ± 6.7°, respectively (P = 0.002, t-test, n = 30); these results are similar to previously reported values (89 ± 6°) of 'flat' films based on chitosan. 24,25 The Wenzel equation relates the contact angles of the flat and nanopatterned adhesives and is in very good agreement with our data:…”

Section: Resultssupporting

confidence: 83%

Gecko-inspired chitosan adhesive for tissue repair

et al. 2016

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The advent of nanotechnology has opened the possibility of fabricating nanoscopic pillars on the surface of polymeric films mimicking the Gecko's foot, in an attempt to increase their adhesive capabilities enhanced by van der Waals forces. However, these forces are considerably weakened in a wet physiological environment. To circumvent this loss in force, current biocompatible adhesives with nanopillars require complex multiple-step fabrication, including an extra layer of adhesive coating to stabilize tissue bonding under physiological conditions. In this report, we describe a simple one-step fabrication process of a single-layer chitosan film that has pillars with base diameter in the range of 100-600 nm and a height of~70 nm. The nanostructured adhesive is laser-bonded to tissue and does not require pillar coating to enhance bonding in water. In comparison with a 'flat' adhesive (without pillars), the nanostructured adhesive bonded significantly stronger to tissue under either stress or pressure. Atomic force spectroscopy also confirmed the superior bonding capability of the nanostructured adhesive. This study demonstrates a one-step fabrication technique to produce a monolayer gecko-inspired adhesive that is biocompatible and bonds effectively to tissue.

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Section: Resultssupporting

confidence: 83%

Gecko-inspired chitosan adhesive for tissue repair

et al. 2016

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“…It comprises (1-4)-2-acetamido-2-deoxy-ß-D-glucan (N-acetyl D-glucosamine) and (1-4)-2-amino-2-deoxy-ß-D-glucan (D-glucosamine) units. It is also a biocompatible and biodegradable polymer and it is osteoconductive, as well as hemostatic and antimicrobial 11 . Chitosan scaffolds are biodegradable and tissue biocompatible.…”

Section: Introductionmentioning

confidence: 99%

Fibers Obtained from Alginate, Chitosan and Hybrid Used in the Development of Scaffolds

et al. 2017

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The main aim of this study was to develop scaffolds based on alginate, chitosan and hybrid fibers with and without glycerol. The scaffolds developed underwent assessments for tensile property, swelling ratio and weight loss, cellular viability, degradation and biomineralization, as well as DSC/TGA thermal analysis. Tenacity values showed that use of glycerol and the interaction between alginate and chitosan as a hybrid fiber were associated with increasing tenacity values. In the swelling and weight loss study, the scaffolds containing glycerol presented lower weight loss and higher water absorption values in all scaffolds, compared to scaffolds without glycerol, indicating that glycerol acted as a stabilizer. None of the alginate, chitosan and hybrid scaffolds, with or without glycerol, decreased cell viability. On the third day of the biomineralization assay, chitosan without glycerol indicated the presence of apatite crystals. The degradation study showed that glycerol may have acted as a stabilizer.

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“…CS is a versatile, abundant, and naturally occurring cationic polyelectrolyte, that has been extensively studied for pharmaceutical and biomedical applications. [19][20][21] Room temperature ionic liquids (ILs) are promising electrolytes because they possess negligible vapour pressure, low flammability, high ionic conductivity and high electrochemical stability. 22,23 Amongst a variety of ILs, choline-based ILs are considered to be promising, low toxicity ILs for a variety of biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

Biocompatible Ionic Liquid–Biopolymer Electrolyte-Enabled Thin and Compact Magnesium–Air Batteries

Jia

Yang

Wang

et al. 2014

ACS Appl. Mater. Interfaces

103

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With the surge of interest in miniaturized implanted medical devices (IMDs), implantable power sources with small dimensions and biocompatibility are in high demand. Implanted battery/supercapacitor devices are commonly packaged within a case that occupies a large volume, making miniaturization difficult. In this study, we demonstrate a polymer electrolyte-enabled biocompatible magnesium-air battery device with a total thickness of approximately 300 μm. It consists of a biocompatible polypyrrole-para(toluene sulfonic acid) cathode and a bioresorbable magnesium alloy anode. The biocompatible electrolyte used is made of choline nitrate (ionic liquid) embedded in a biopolymer, chitosan. This polymer electrolyte is mechanically robust and offers a high ionic conductivity of 8.9 x 10-3 S cm-1. The assembled battery delivers a maximum volumetric power density of 3.9 W L-1, which is sufficient to drive some types of IMDs, such as cardiac pacemakers or biomonitoring systems. This miniaturized, biocompatible magnesium-air battery may pave the way to a future generation of implantable power sources. Abstract:With the surge of interest in miniaturized implanted medical devices (IMDs), implantable power sources with small dimensions and biocompatibility are in high demand. Implanted battery/supercapacitor devices are commonly packaged within a case that occupies a large volume making miniaturization difficult. In this study, we demonstrate a polymer electrolyte enabled biocompatible magnesium-air battery device with a total thickness of approximately 300 µm. It consists of a biocompatible polypyrrole-para(toluene sulfonic acid) cathode and a bioresorbable magnesium alloy anode. The biocompatible electrolyte used is made of choline nitrate (ionic liquid) embedded in a biopolymer, chitosan. This polymer electrolyte is mechanically robust and offers a high ionic conductivity of 8.9×10 -3 S cm -1 . The assembled battery delivers a maximum volumetric power density of 3.9 W L -1 , which is sufficient to drive some types of IMDs such as cardiac pacemakers or bio-monitoring systems. This miniaturized, biocompatible magnesium-air battery may pave a way to the future generation of implantable power sources.

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Chitosan-based biomaterials for tissue engineering

Cited by 1,810 publications

References 140 publications

Gecko-inspired chitosan adhesive for tissue repair

Gecko-inspired chitosan adhesive for tissue repair

Fibers Obtained from Alginate, Chitosan and Hybrid Used in the Development of Scaffolds

Biocompatible Ionic Liquid–Biopolymer Electrolyte-Enabled Thin and Compact Magnesium–Air Batteries

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