Chitosan as excellent bio-macromolecule with myriad of anti-activities in biomedical applications – A review

Jagdale, Sachin; Agarwal, Babita; Dixit, Abhishek; Gaware, Saurabh

doi:10.1016/j.ijbiomac.2023.128697

Cited by 10 publications

(3 citation statements)

References 176 publications

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“…As already pointed out in the Introduction, and because of its unique structure, chitosan exhibits plenty of intrinsic therapeutical properties [60,62,63,77,91,207,208], summarized in Table 2 (containing some updated references).…”

Section: Dess For the Generation Of Chitinaceous Bioactive Materialsmentioning

confidence: 99%

“…However, it should be noted that it is difficult to work with chitin, as it is insoluble in aqueous acidic media due to its acetylated residues [45,56,57]. Thus, efforts have been made to use chitin to produce more soluble compounds, such as chitosan [58][59][60][61][62][63], a biopolymer generally obtained via the chemical [64] or biotechnological [65,66] deacetylation of chitin, which exhibits a unique, versatile, and variable structure [67][68][69][70][71][72][73]. Structurally, chitosan (Figure 2b) is a copolymer formed D-glucosamine units (GlcN, major component, Figure 2) and GlcNAc units [74] connected by linear β-(1,4)-links (Figure 2b).…”

Section: Introductionmentioning

confidence: 99%

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Strategies to Prepare Chitin and Chitosan-Based Bioactive Structures Aided by Deep Eutectic Solvents: A Review

Durante-Salmerón,

Fraile-Gutiérrez,

Gil-Gonzalo

et al. 2024

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Chitin and chitosan, abundant biopolymers derived from the shells of crustaceans and the cell walls of fungi, have garnered considerable attention in pharmaceutical circles due to their biocompatibility, biodegradability, and versatile properties. Deep eutectic solvents (DESs), emerging green solvents composed of eutectic mixtures of hydrogen bond acceptors and donors, offer promising avenues for enhancing the solubility and functionality of chitin and chitosan in pharmaceutical formulations. This review delves into the potential of utilizing DESs as solvents for chitin and chitosan, highlighting their efficiency in dissolving these polymers, which facilitates the production of novel drug delivery systems, wound dressings, tissue engineering scaffolds, and antimicrobial agents. The distinctive physicochemical properties of DESs, including low toxicity, low volatility, and adaptable solvation power, enable the customization of chitin and chitosan-based materials to meet specific pharmaceutical requirements. Moreover, the environmentally friendly nature of DESs aligns with the growing demand for sustainable and eco-friendly processes in pharmaceutical manufacturing. This revision underscores recent advances illustrating the promising role of DESs in evolving the pharmaceutical applications of chitin and chitosan, laying the groundwork for the development of innovative drug delivery systems and biomedical materials with enhanced efficacy and safety profiles.

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Section: Dess For the Generation Of Chitinaceous Bioactive Materialsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Strategies to Prepare Chitin and Chitosan-Based Bioactive Structures Aided by Deep Eutectic Solvents: A Review

Durante-Salmerón,

Fraile-Gutiérrez,

Gil-Gonzalo

et al. 2024

Catalysts

View full text Add to dashboard Cite

show abstract

“…As current scientific reviews and books show, intensive research on the properties of chitosan is still ongoing, and recent years have brought about great interest in chitosan from two particular perspectives: drug delivery (i.e., the design of modern drugs) [55,56] and packaging systems [57,58]. Chitosan-based films are a promising innovation in active food packaging, as they possess antioxidant and antimicrobial properties.…”

Section: Introductionmentioning

confidence: 99%