Chitosan as a capping agent: Insights on the stabilization of gold nanoparticles

Franconetti, Antonio; Carnerero, José M.; Prado‐Gotor, Rafael; Cabrera‐Escribano, Francisca; Jaime, Carlos

doi:10.1016/j.carbpol.2018.12.046

Cited by 39 publications

(27 citation statements)

References 43 publications

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“…Chitosan has been used as a capping agent to stabilize the colloidal dispersion, and to control the morphology and optical properties of metal nanoparticles including gold (Au) [ 46 ], silver (Ag) [ 47 ], copper (Cu) [ 48 ], etc. Capping of Au nanoparticles with chitosan is used as a temperature manipulation sign.…”

Section: Introductionmentioning

confidence: 99%

Role of capping agents in the application of nanoparticles in biomedicine and environmental remediation: recent trends and future prospects

et al. 2020

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Capping agents are of utmost importance as stabilizers that inhibit the over-growth of nanoparticles and prevent their aggregation/coagulation in colloidal synthesis. The capping ligands stabilize the interface where nanoparticles interact with their medium of preparation. Specific structural features of nanoparticles are attributed to capping on their surface. These stabilizing agents play a key role in altering the biological activities and environmental perspective. Stearic effects of capping agents adsorbed on the surface of nanoparticles are responsible for such changing physico-chemical and biological characteristics. Firstly, this novel review article introduces few frequently used capping agents in the fabrication of nanoparticles. Next, recent advancements in biomedicine and environmental remediation approaches of capped nanoparticles have been elaborated. Lastly, future directions of the huge impact of capping agents on the biological environment have been summarized.

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Section: Introductionmentioning

confidence: 99%

Role of capping agents in the application of nanoparticles in biomedicine and environmental remediation: recent trends and future prospects

et al. 2020

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“…In the present report, chitosan was used as a capping agent for AuNPs. Chitosan has been explored as a drug/gene delivery vehicle due to its high biocompatibility, low allergenicity, biodegradability, and low toxicity [24–26]. Chitosan originates from chitin, which is abundant in the exoskeletons of insects and crustaceans such as crabs, lobsters, and shrimp.…”

Section: Introductionmentioning

confidence: 99%

“…Chitosan itself possesses antibacterial, antifungal, antitumor, and antioxidant activity [25]. As a capping agent, chitosan directly contacts AuNPs through an electrosteric mechanism [26]. Chitosan nanoparticles affect the mechanism of cellular uptake by A549 cells without modifying cytotoxicity [24].…”

Section: Introductionmentioning

confidence: 99%

Shape-dependent cytotoxicity and cellular uptake of gold nanoparticles synthesized using green tea extract

2019

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In the present report, three different shapes of chitosan-capped gold nanoparticles (nanospheres, nanostars, and nanorods) were synthesized to investigate the effects of shape on cytotoxicity and cellular uptake in cancer cells. Green tea extract was utilized as a reducing agent to reduce gold salts to gold nanospheres. Gold nanostars were prepared using an as-prepared nanosphere solution as a seed solution. Gold nanorods were synthesized using a conventional method. All three types of gold nanoparticles showed their characteristic surface plasmon resonance bands upon UV-visible spectrophotometry. In high-resolution transmission electron microscopy images, lattice structures were clearly observed in all three shapes, confirming the crystalline nature of the nanoparticles. All three colloidal solutions of gold nanoparticles retained colloidal stability in various solutions. To assess cytotoxicity, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed on four cancer cell lines. The cytotoxicity was the highest in nanorods, followed by nanostars and finally nanospheres. The cellular uptake of gold nanoparticles in human hepatocyte carcinoma cells (HepG2) was measured, and the results followed the order nanospheres > nanorods > nanostars. The outcomes of the current study may assist in the shape design of gold nanoparticles for therapeutic applications as drug delivery vehicles in the field of nanomedicine.

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“…Further, chitosan acts as a reducing agent of Au +3 and a stabilizing agent of AuNPs with the geometry of a quasi-spherical shape. AuNPs have been verified by UV–Vis absorption spectra, SEM images of chitosan-AuNPs and TEM images of AuNPs [ 35 ].…”

Section: Resultsmentioning

confidence: 99%

Characterization and Electrical Properties of PVA Films with Self-Assembled Chitosan-AuNPs/SWCNT-COOH Nanostructures

et al. 2020

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Nanostructured films with electrical conductivity in the semiconductor region were prepared in a polymeric matrix of poly(vinyl alcohol) (PVA) with nanostructures of chitosan-gold nanoparticles (AuNPs)/single-wall carbon nanotubes carboxylic acid functionalized (SWCNT-COOH) (chitosan-AuNPs/SWCNT-COOH) self-assembled. Dispersion light scattering (DLS) was used to determine the average particle sizes of chitosan-AuNPs, z-average particle size (Dz) and number average particle size (Dn), and the formation of crystalline domains of AuNPs was demonstrated by X-ray diffraction (XRD) patterns and observed by means of transmission electron microscopy (TEM). The electrostatic interaction was verified by Fourier transform infrared spectroscopy (FTIR). The electrical conductivity of PVA/chitosan-AuNPs/SWCNT-COOH was determined by the four-point technique and photocurrent. The calculated Dn values of the chitosan-AuNPs decreased as the concentration of gold (III) chloride trihydrate (HAuCl4·3H2O) increased: the concentrations of 0.4 and 1.3 mM were 209 and 90 nm, respectively. Average crystal size (L) and number average size (D) of the AuNPs were calculated in the range of 13 to 24 nm. Electrical conductivity of PVA/chitosan-AuNPs/SWCNT-COOH films was 3.7 × 10−5 σ/cm determined by the four-point technique and 6.5 × 10−4 σ/cm by photocurrent for the SWCNT-COOH concentration of 0.5 wt.% and HAuCl4·3H2O concentration of 0.4 mM. In this investigation, the protonation of the amine group of chitosan is fundamental to prepare PVA films with nanostructures of self-assembled chitosan-AuNPs/SWCNT-COOH.

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Chitosan as a capping agent: Insights on the stabilization of gold nanoparticles

Cited by 39 publications

References 43 publications

Role of capping agents in the application of nanoparticles in biomedicine and environmental remediation: recent trends and future prospects

Role of capping agents in the application of nanoparticles in biomedicine and environmental remediation: recent trends and future prospects

Shape-dependent cytotoxicity and cellular uptake of gold nanoparticles synthesized using green tea extract

Characterization and Electrical Properties of PVA Films with Self-Assembled Chitosan-AuNPs/SWCNT-COOH Nanostructures

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