Chitosan as a bioactive polymer: Processing, properties and applications

Muxika, A.; Etxabide, Alaitz; Uranga, Jone; Caba, Koro de la

doi:10.1016/j.ijbiomac.2017.07.087

Cited by 889 publications

(479 citation statements)

References 109 publications

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“…; Muxika et al . ). When the proportion of glucosamine exceeds the proportion of N‐acetyl glucosamine, corresponding to a degree of deacetylation (DD) of more than 50%, the polymer is termed chitosan (Khor and Lim ; Ramírez et al .…”

Section: Introductionmentioning

confidence: 97%

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Challenges and opportunities related to the use of chitosan as a food preservative

Gänzle

2018

J Appl Microbiol

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Summary Chitosan has attracted a growing attention as a food preservative due to its versatility, nontoxicity, biodegradability and biocompatibility. This review aims to provide a critical appraisal of the limitations and opportunities of the use of chitosan as a food preservative. The application of chitosan as a food preservative necessitates insights into mechanisms of chitosan‐mediated cell death and injury, factors affecting chitosan activity and effects of chitosan on food safety and quality. Chitosan exerts antimicrobial activity by perturbing the negatively charged cell envelope of micro‐organisms with its polycationic structure. Intrinsic characteristics, including molecular weight and degree of deacetylation (DD), and other ambient conditions, including pH, temperature and neighbouring components, affect chitosan activity. Because the antimicrobial activity of chitosan is mainly based on ionic interactions with negatively charged components of the bacterial cell envelope, the food matrix can strongly interfere with the antimicrobial activity of chitosan. Despite its limited antimicrobial efficacy, chitosan demonstrates both bactericidal and bacteriostatic effects in specific food products. Moreover, chitosan can also enhance the efficacy of commercial intervention technologies, such as heat and pressure treatment, and aid the preservation of food quality, including retardation of lipid oxidation, weight loss and deterioration in sensory attributes.

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Section: Introductionmentioning

confidence: 97%

“…; Muxika et al . ). While several reviews indicate the potential applications of chitosan as a food preservative, challenge studies in food often report only a limited effect of chitosan on pathogens or spoilage organisms.…”

Section: Introductionmentioning

confidence: 97%

Challenges and opportunities related to the use of chitosan as a food preservative

Gänzle

2018

J Appl Microbiol

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“…Over the last decades, chitosan (CHIT), a linear biopolymer of glucosamine and N ‐acetyl‐glucosamine obtained by deacetylation of chitin, has been receiving great interest by virtue of its advantageous features. Many researchers exploited its biocompatibility, biodegradability, bioadhesivity, wound‐healing efficacy, and bacteriostatic effects for the fabrication of smart hydrogels for biomedical, pharmaceutical, wastewater purification, as well as for food industry applications . Due to its chemical functionalities (ionizable NH 2 groups), CHIT confers pH responsivity when inserted into hydrogel networks .…”

Section: Introductionmentioning

confidence: 99%

Chitosan–Quercetin Bioconjugate as Multi‐Functional Component of Antioxidants and Dual‐Responsive Hydrogel Networks

Cirillo

Curcio

Spizzirri

et al. 2019

Macro Materials & Eng

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Multifunctional hydrogels based on chitosan–quercetin (CHITQ) conjugate are prepared by a thermo‐induced radical procedure in the presence of N‐isopropylacrylamide (NIPAAm), acrylamide (AAm), and N,N′‐methylenebis(acrylamide) (MEBA). At first, quercetin (Q) is grafted onto chitosan backbone with a functionalization degree of 275 mg of Q per gram of conjugate, as calculated by 1H‐NMR analyses to impart antioxidant properties to the polysaccharide. Then, a pH and temperature sensitive hydrogel was obtained by involving CHITQ and NIPAAm in the polymerization reaction. The accessibility of phenolic moieties is modified in response to the hydrogel swelling/deswelling, as confirmed by antioxidant tests performed at different temperatures. Dual stimuli‐responsive hydrogels are proposed for the delivery of caffeine as model drug. The release profiles of caffeine depict a system particularly performing as on/off device at acidic pH with excellent applicability prospects.

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“…The major features of regenerated cellulose fibers include a variable morphology and variable physical properties, softness, good processing characteristics, adequate liquid transport properties and good mechanical properties [4,6,[9][10][11][12][13][14]. In recent decades, many applications of regenerated cellulose fibers have been developed, not only as clothing but also as medical and sanitary products, for which a high uptake of aqueous fluids is part of the essential performance requirements [10][11][12]15].…”

Section: Introductionmentioning

confidence: 99%

“…In order to enhance absorption properties further, many studies have been conducted and a variety of techniques have been utilized [4,7,13,14]. These methods mainly focused on chemical or mechanical treatments [8][9][10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Chitosan Based Regenerated Cellulose Fibers Functionalized with Plasma and Ultrasound

2018

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Abstract:The great potential of regenerated cellulose fibers, which offer excellent possibilities as a matrix for the design of bioactive materials, was the lead for our research. We focused on the surface modification of fibers to improve the sorption properties of regenerated cellulose and biocomposite regenerated cellulose/chitosan fibers, which are on the market. The purpose of our investigation was also the modification of regenerated cellulose fibers with the functionalization by chitosan as a means of obtaining similar properties to biocomposite regenerated cellulose/chitosan fibers on the market. Argon gas plasma was used for fiber surface activation and chitosan adsorption. Ultrasound was also used as a treatment procedure for the surface activation of regenerated cellulose fibers and treatment with chitosan. Analyses have shown that ultrasonic energy or plasma change the accessibility of free functional groups, structure and reactivity, especially in regenerated cellulose fibers. Changes that occurred in the morphology and in the structure of fibers were also reflected in their physical and chemical properties. Consequently, moisture content, sorption properties and water retention improved.

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Chitosan as a bioactive polymer: Processing, properties and applications

Cited by 889 publications

References 109 publications

Challenges and opportunities related to the use of chitosan as a food preservative

Challenges and opportunities related to the use of chitosan as a food preservative

Chitosan–Quercetin Bioconjugate as Multi‐Functional Component of Antioxidants and Dual‐Responsive Hydrogel Networks

Chitosan Based Regenerated Cellulose Fibers Functionalized with Plasma and Ultrasound

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