Chitosan and their derivatives: Antibiofilm drugs against pathogenic bacteria

Khan, Fazlurrahman; Pham, Dung Thuy Nguyen; Oloketuyi, Sandra Folarin; Manivasagan, Panchanathan; Oh, Junghwan; Kim, Young‐Mog

doi:10.1016/j.colsurfb.2019.110627

Cited by 166 publications

(120 citation statements)

References 197 publications

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…Chitosan is one of the biopolymers with linear polysaccharide composed of randomly distributed β-(1→ 4)linked D-glucosamine and N-acetyl-D-glucosamine. Chitosan itself can act as antibacterial and antibiofilm agents due to its polycationic nature's ability to disrupt bacterial membrane (Khan et al, 2020). Chitosan-based nanoparticles have been broadly used as drug delivery systems.…”

Section: Nanoparticle Types Used For Antibacterial Applicationmentioning

confidence: 99%

Nano-Based Drug Delivery or Targeting to Eradicate Bacteria for Infection Mitigation: A Review of Recent Advances

et al. 2020

View full text Add to dashboard Cite

Section: Nanoparticle Types Used For Antibacterial Applicationmentioning

confidence: 99%

Nano-Based Drug Delivery or Targeting to Eradicate Bacteria for Infection Mitigation: A Review of Recent Advances

et al. 2020

View full text Add to dashboard Cite

“…15,120 In the quest for more efficient antimycobacterial drugs that are able to overcome the "classical" issues discussed above and partially responsible for the global TB status, the antibacterial peptides and nanoparticles gained recently special attention. 19,121 Several classes of nanoparticles with intrinsic antibacterial and antibiofilm effects are proven, 122 including metallic nanoparticles (e.g copper, 123 iron, 124 gold 125 or silver-based 126 ), carbon nanotubes, 127 polysaccharides as chitosan 128 and chitosan in conjunction with polycationic polymer 129 or combinations of the above-mentioned antibacterial molecules as chitosan-gold NP. 130 Among these antibacterial nanoparticles, due to their strong antibacterial activity and long-history of using silver as antiseptic, AgNPs have received most of the attention.…”

Section: Silver Nanoparticles As An Emerging Therapeutic Approach In mentioning

confidence: 99%

<p>Silver Nanoparticles for the Therapy of Tuberculosis</p>

Tabaran

Matea²,

Mocan³

et al. 2020

IJN

View full text Add to dashboard Cite

Rapid emergence of aggressive, multidrug-resistant Mycobacteria strain represents the main cause of the current antimycobacterial-drug crisis and status of tuberculosis (TB) as a major global health problem. The relatively low-output of newly approved antibiotics contributes to the current orientation of research towards alternative antibacterial molecules such as advanced materials. Nanotechnology and nanoparticle research offers several exciting new-concepts and strategies which may prove to be valuable tools in improving the TB therapy. A new paradigm in antituberculous therapy using silver nanoparticles has the potential to overcome the medical limitations imposed in TB treatment by the drug resistance which is commonly reported for most of the current organic antibiotics. There is no doubt that AgNPs are promising future therapeutics for the medication of mycobacterial-induced diseases but the viability of this complementary strategy depends on overcoming several critical therapeutic issues as, poor delivery, variable intramacrophagic antimycobacterial efficiency, and residual toxicity. In this paper, we provide an overview of the pathology of mycobacterial-induced diseases, andhighlight the advantages and limitations of silver nanoparticles (AgNPs) in TB treatment.

show abstract

“…Deacetylation, chemical modification by adding hydrophilic biomolecules to amino or hydroxyl groups (acylation, carboxylation, alkylation, quaternization, sulfonation, and phosphorylation), crosslinking and chemical or enzymatical depolymerization or degradation are available methods for improving the solubility of chitosan and also optimizing its biological properties [ 29 , 30 ]. Because of the diverse properties of chitosan and its derivatives, they have been extensively applied in the medical and pharmaceutical fields, for example, they have been used in drug delivery [ 31 , 32 ], tissue engineering [ 20 , 33 ], wound management [ 34 , 35 ], gene and cancer therapy [ 36 , 37 , 38 ], antibiofilm drugs [ 39 ], etc.…”

Section: Structure Properties and Applications Of Chitosanmentioning

confidence: 99%

Chitosan-Based Biomimetically Mineralized Composite Materials in Human Hard Tissue Repair

Ren

et al. 2020

Molecules

View full text Add to dashboard Cite

Chitosan is a natural, biodegradable cationic polysaccharide, which has a similar chemical structure and similar biological behaviors to the components of the extracellular matrix in the biomineralization process of teeth or bone. Its excellent biocompatibility, biodegradability, and polyelectrolyte action make it a suitable organic template, which, combined with biomimetic mineralization technology, can be used to develop organic-inorganic composite materials for hard tissue repair. In recent years, various chitosan-based biomimetic organic-inorganic composite materials have been applied in the field of bone tissue engineering and enamel or dentin biomimetic repair in different forms (hydrogels, fibers, porous scaffolds, microspheres, etc.), and the inorganic components of the composites are usually biogenic minerals, such as hydroxyapatite, other calcium phosphate phases, or silica. These composites have good mechanical properties, biocompatibility, bioactivity, osteogenic potential, and other biological properties and are thus considered as promising novel materials for repairing the defects of hard tissue. This review is mainly focused on the properties and preparations of biomimetically mineralized composite materials using chitosan as an organic template, and the current application of various chitosan-based biomimetically mineralized composite materials in bone tissue engineering and dental hard tissue repair is summarized.

show abstract

Chitosan and their derivatives: Antibiofilm drugs against pathogenic bacteria

Cited by 166 publications

References 197 publications

Nano-Based Drug Delivery or Targeting to Eradicate Bacteria for Infection Mitigation: A Review of Recent Advances

Nano-Based Drug Delivery or Targeting to Eradicate Bacteria for Infection Mitigation: A Review of Recent Advances

<p>Silver Nanoparticles for the Therapy of Tuberculosis</p>

Chitosan-Based Biomimetically Mineralized Composite Materials in Human Hard Tissue Repair

Contact Info

Product

Resources

About