Chitosan and poly(methyl vinyl ether-co-maleic anhydride) microparticles as nasal sustained delivery systems

Cerchiara, Teresa; Luppi, Barbara; Chidichimo, Giuseppe; Bigucci, Federica; Zecchi, Vittorio

doi:10.1016/j.ejpb.2005.05.005

Cited by 57 publications

(21 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The adhered microspheres amount was estimated from the difference between the applied microparticles amount and the flowed microparticles amount. The ratio of adhered microparticles was computed percent mucoadhesion using following equation [9].…”

Section: In Vitro Mucoadhesive Strength Determinationmentioning

confidence: 99%

Formulation of sildenafil citrate loaded nasal microsphers: An in vitro, ex vivo characterization.

Shah¹,

Sharma²,

Vijay³

et al. 2010

Int j Drug delivery

View full text Add to dashboard Cite

The aim of the present study was to prepare gellan gum microspheres of Sildenafil citrate, for intranasal delivery to avoid the first pass metabolism. The microspheres were prepared using spray drying method. The microspheres were evaluated for characteristics like particle size, incorporation efficiency, swelling ability, zeta potential, in-vitro mucoadhesion, ex-vivo mucoadhesion, thermal analysis, XRD study and invitro drug release. Treatment of in-vitro data to different kinetic equations indicated diffusion controlled drug delivery from gellan gum microspheres. The results of DSC and XRD studies revealed the molecular amorphous dispersion of Sildenafil citrate into the gellan gum microspheres. Microspheres so prepared were discrete, bulky, free flowing and showed an average encapsulation efficiency ranging from 95-98%. The formulation exhibited a good mucoadhesive strength which was determined in in vitro conditions through falling film technique and was compared with ex vivo studies. The microspheres so prepared also exhibited a good swelling index which confirmed the strong mucoadhesive property of the formulation.

show abstract

Section: In Vitro Mucoadhesive Strength Determinationmentioning

confidence: 99%

Formulation of sildenafil citrate loaded nasal microsphers: An in vitro, ex vivo characterization.

Shah¹,

Sharma²,

Vijay³

et al. 2010

Int j Drug delivery

View full text Add to dashboard Cite

show abstract

“…The donor compartment contained 3 ml of SNES and receiver compartment was filled with phosphate buffer solution pH 6.6 that was within the pH range in nasal cavity and maintained at 37Ϯ0.5°C. 6) Samples were periodically withdrawn from the receptor compartment, replaced with the same amount of fresh buffer solution, and assayed by a spectrophotometer at 307 nm.…”

Section: X-ray Diffraction (Xrd) Studiesmentioning

confidence: 99%

Gellan Gum Based Microparticles of Metoclopromide Hydrochloride for Intranasal Delivery: Development and Evaluation

Mahajan

Gattani

2009

Chem. Pharm. Bull.

View full text Add to dashboard Cite

The purpose of this study was to develop nasal microparticles of metoclopromide employing gellan gum as a polymer by spray drying method. This method of microencapsulation is particularly less dependent on the solubility characteristics of the drug and polymer and is simple, reproducible, and easy to scale up. The microparticles were evaluated for characteristics like particle size, incorporation efficiency, swelling ability, zeta potential, mucoadhesion, thermal analysis, X-ray diffraction (XRD) study and in vitro drug release. The microparticles so prepared had irregular shape and smooth but distorted surface morphology. They were negatively charged. The particle size ranged from 9.38 to 10.67 m mm. Differential scanning calorimetry (DSC) studies revealed that metoclopromide was molecularly dispersed inside the microparticles. The swelling was increased with increase in amount of polymer. The release of drug from microparticles was moderately sustained without lag time and attributed to formation of hydrogel; ionically cross linked hydrogel was hypothesized. The formulation was found to be non toxic to nasal tissue. These in vitro preliminary results show that spray dried microparticles based on gellan gum could be suitable nasal delivery system for the administration of metoclopromide.

show abstract

“…A band appearing at 3327 cm À 1 in the IR spectrum of Dox in Figure 2 is due to O-H/N-H stretching vibrations, while the band observed at 2933 cm À 1 is due to the C-H stretching vibrations (Li et al, 2009;Wu et al, 2013 (Cerchiara et al, 2005;Guhagarkar et al, 2010;Benival & Devarajan, 2012;Date et al, 2013). The intensive, broad hydroxyl band at 3000-3600 cm À1 along with C-O-C stretching at 1000-1260 cm À1 confirmed adsorption of the carbohydrates on the nanoparticles (Cheng et al, 2010).…”

Section: Ftirmentioning

confidence: 79%

Polyethylene sebacate doxorubicin nanoparticles: role of carbohydrate anchoring on in vitro and in vivo anticancer efficacy

et al. 2016

View full text Add to dashboard Cite

We report carbohydrate-anchored polyethylene sebacate (PES)-Gantrez Õ AN 119 Doxorubicin hydrochloride (Dox) nanoparticles (NPs) for enhanced anticancer efficacy. The carbohydrates Arabinogalactan (AGn), an adjuvant in anticancer chemotherapy and pullulan (Pul) reported to promote collagen synthesis, were selected as ligands. PES Dox NPs of an average size around 200 nm, greater than 20% w/w Dox loading and negative zeta potential were anchored with Pul, AGn, and Pul-AGn combination by simple incubation. Increase in particle size and zeta potential confirmed carbohydrate anchoring. FTIR confirmed ionic complexation of Dox and Gantrez Õ AN 119. DSC and XRD demonstrated amorphization of Dox. Higher Dox release in pH 5.5 as compared with pH 7.4 is beneficial for reduced systemic toxicity and enhanced drug release in tumors. Good in vitro serum stability and low hemolysis revealed suitability for intravenous administration. All NPs revealed circulation longevity in normal rats. Pul NPs revealed superior anticancer efficacy in vitro and an 11-fold enhancement in uptake in MCF-7 breast cancer cells. The greater efficacy in vivo is attributed to possible pullulan-mediated integrin receptor uptake and interaction with tumor collagen. Histopathology confirmed safety and suggested promise of Pul NPs in improved anticancer efficacy.

show abstract

Chitosan and poly(methyl vinyl ether-co-maleic anhydride) microparticles as nasal sustained delivery systems

Cited by 57 publications

References 15 publications

Formulation of sildenafil citrate loaded nasal microsphers: An in vitro, ex vivo characterization.

Formulation of sildenafil citrate loaded nasal microsphers: An in vitro, ex vivo characterization.

Gellan Gum Based Microparticles of Metoclopromide Hydrochloride for Intranasal Delivery: Development and Evaluation

Polyethylene sebacate doxorubicin nanoparticles: role of carbohydrate anchoring on in vitro and in vivo anticancer efficacy

Contact Info

Product

Resources

About