Chitosan and Its Derivatives for Drug Delivery Perspective

Sonia, Thundiparambil Azeez; Sharma, Chandra P.

doi:10.1007/12_2011_117

Cited by 227 publications

(154 citation statements)

References 135 publications

Supporting

Mentioning

139

Contrasting

Order By: Relevance

“…This could be attributed to the presence of a mucoadhesive polymer that ensures close contact between the drug and membrane. Additionally, the higher swelling index of this formula allows for the creation of pores and channels at the tablet surface, thus allowing ready diffusion of the drug through the tablets [25][26][27].…”

Section: Discussionmentioning

confidence: 99%

Preparation and evaluation of mebeverine hydrochloride as mucoadhesive buccal tablet for local anesthesia

Abdulhady¹,

Hosny²

2017

Trop. J. Pharm Res

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Preparation and evaluation of mebeverine hydrochloride as mucoadhesive buccal tablet for local anesthesia

Abdulhady¹,

Hosny²

2017

Trop. J. Pharm Res

View full text Add to dashboard Cite

“…Hence, it will form better hydrogel at low pH. Conversely, chitosan has a pKa of 6.5 (Sonia and Sharma, 2011) and being a basic polymer, it will undergo full ionization and exhibit maximum solubility at low pH (Aulton, 2007). This could be responsible for the better activity of chitosan as a permeation enhancer at low pH (Yin et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…The amino group in chitosan has a pKa of 6.5 which leads to a protonation of acidic to neutral solution. This makes chitosan water-soluble and a bioadhesive which readily bonds to negatively charged surfaces such as mucosal membrane (Sonia and Sharma, 2011). Chitosan has found a wide application as a drug delivery agent (Hu et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Extraction and physicochemical characterization of a potential multifunctional pharma-excipient from crab shell wastes

Olorunsola¹,

Olayemi²,

Majekodunmi³

et al. 2015

Afr. J. Biotechnol.

View full text Add to dashboard Cite

An efficient and beneficial waste disposal mechanism is highly desired. This study was carried out to extract and characterize a potential multifunctional pharmaceutical excipient from crab shell wastes. Shells of Pachygrapsus mamoratus were obtained from Oron, a coastal town in Akwa Ibom State of Nigeria. Chitin was extracted from the powdered shell by deproteination and demineralization; and chitosan was derived by alkaline deacetylation of the chitin. The polymer was subjected to Fourier transform infrared (FTIR) spectroscopy and differential scanning calorimetry (DSC). It was also evaluated for flow properties, pH and hydration and swelling characteristics. The shells gave a yield of 17% chitosan. FTIR analysis of the polymer showed C-H bond of substituted cyclic hydrocarbon, cyclic C-N bond, C-O bond of glucose molecules, C-H bond of side chain -CH 2 OH, presence of β-ester linkage, N-H of amides and bonded and free O-H groups. The last transition in the thermogram of chitosan was a polymer degradation exotherm with a peak at 337.9°C. The chitosan had higher bulk density, higher flow rate, lower Carr's index and lower Hausner's ratio compared to sodium carboxymethylcellulose. It also had lower hydration and swelling capacities. Therefore, the crab shell-derived chitosan has better thermal stability, better flow properties but poorer swelling properties compared to sodium carboxymethylcelluose.

show abstract

“…It is a deacetylated product of chitin which is a major component of the shells of crustaceans such as shrimps and crabs [3]. Chitosan has limited solubility, high biodegradability and it is non-toxic [4]. These properties are desirable of a good disintegrant.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Callinectes Chitosan as a Superdisintegrant in Metronidazole Tablet

Olorunsola

Adedokun

Akpabio

2017

Int J Pharm Pharm Sci

View full text Add to dashboard Cite

Objective: The objective of this study is to evaluate callinectes chitosan as a superdisintegrant in tablet formulation; superdisintegrants are incorporated into tablets at concentrations below 5% of tablet weight to effect prompt break-up of tablets after administration. Methods:Chitosan was extracted from shells of Callinectes gladiator. The polymer was characterized and then used as a disintegrant (in comparison with Ac-Di-Sol ® and corn starch) at concentrations of 2, 4 and 8% for the formulation of metronidazole tablets. The micromeritic properties of granules; and mechanical and release properties of the tablets were studied.Results: A yield of 36.7% chitosan having degree of deacetylation of 62.7% was obtained from the crab shell. Fourier Transform Infrared absorption bands at 1495 and 3240 cm -1 typical of N-H bending and stretching respectively; and endothermic peak of 159 °C typical of melting of chitosan were obtained. No adverse interaction between the chitosan and metronidazole was observed. The disintegration times of tablets containing 2, 4 and 8% chitosan were 12.2, 10.4 and 9.3 min respectively. Conclusion:Callinectes chitosan is suitable for use as a superdisintegrant in tablets. It appears to be superior to corn starch as disintegrant although less effective compared to Ac-Di-Sol ® . However, the relative cheapness and ready availability of chitosan would make it to be preferred to Ac-Di-Sol ® .

show abstract

Chitosan and Its Derivatives for Drug Delivery Perspective

Cited by 227 publications

References 135 publications

Preparation and evaluation of mebeverine hydrochloride as mucoadhesive buccal tablet for local anesthesia

Preparation and evaluation of mebeverine hydrochloride as mucoadhesive buccal tablet for local anesthesia

Extraction and physicochemical characterization of a potential multifunctional pharma-excipient from crab shell wastes

Evaluation of Callinectes Chitosan as a Superdisintegrant in Metronidazole Tablet

Contact Info

Product

Resources

About