Chitosan and its derivatives-based nano-formulations in drug delivery

Tian, Ye; Sun, Yujiao; Wang, Xiaodan; Kasparis, Georgios; Mao, Shirui

doi:10.1016/b978-0-323-42866-8.00015-0

Cited by 3 publications

(7 citation statements)

References 280 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The degree of substitution was easily controlled by adjusting the number of fatty acids. After being grafted on the CS chain, the fatty chains increased the hydrophobicity and changed the structural features of the copolymer, which tended to self-assemble driven by hydrophobic forces [20]. Recently, Nanda et al [29] developed an acylated CS (myristoyl and octanoyl) coated paclitaxel-loaded liposomal formulation to overcome the cremophor EL related toxicities.…”

Section: Chitosan Derivative Groups/derivatives Formulamentioning

confidence: 99%

“…Further increase in the DQ does not have a significant effect on absorption and shows increased toxicity. By quaternizing CS, thermosensitive hydrogels have been formed (e.g., for nasal drug delivery) [20]. Quarternization, the opposite of alkylation, increases the hardness of CS.…”

Section: Ionic Chitosan Derivatives (With Cationic and Anionic Substituents)mentioning

confidence: 99%

“…It is an excellent absorption enhancer for intranasal drug delivery. As a drug carrier, N-succinyl-CS can readily prepare drug conjugates with various drugs due to-H 2 and -COOH groups in its structure [20,35]. Palacio et al [36] prepared succinyl-chitosan (SCS) nanoparticles by the ionic crosslinking method for polyphenols encapsulation and theoretically studied the interaction between SCS and polyphenols.…”

Section: Ionic Chitosan Derivatives (With Cationic and Anionic Substituents)mentioning

confidence: 99%

“…Therefore, a great emphasis is laid on the development of various CS derivatives as has been documented by several recent review papers. Negm et al [19] and Tian et al [20] presented advancements on modification of CS biopolymer and potential applications of new CS derivatives. Mateescu et al [21] reviewed the self-assembled systems based on CS derivatives for drug delivery.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

244

120

View full text Add to dashboard Cite

Nanoparticles (NPs) have an outstanding position in pharmaceutical, biological, and medical disciplines. Polymeric NPs based on chitosan (CS) can act as excellent drug carriers because of some intrinsic beneficial properties including biocompatibility, biodegradability, non-toxicity, bioactivity, easy preparation, and targeting specificity. Drug transport and release from CS-based particulate systems depend on the extent of cross-linking, morphology, size, and density of the particulate system, as well as physicochemical properties of the drug. All these aspects have to be considered when developing new CS-based NPs as potential drug delivery systems. This comprehensive review is summarizing and discussing recent advances in CS-based NPs being developed and examined for drug delivery. From this point of view, an enhancement of CS properties by its modification is presented. An enhancement in drug delivery by CS NPs is discussed in detail focusing on (i) a brief summarization of basic characteristics of CS NPs, (ii) a categorization of preparation procedures used for CS NPs involving also recent improvements in production schemes of conventional as well as novel CS NPs, (iii) a categorization and evaluation of CS-based-nanocomposites involving their production schemes with organic polymers and inorganic material, and (iv) very recent implementations of CS NPs and nanocomposites in drug delivery.

show abstract

Section: Chitosan Derivative Groups/derivatives Formulamentioning

confidence: 99%

Section: Ionic Chitosan Derivatives (With Cationic and Anionic Substituents)mentioning

confidence: 99%

Section: Ionic Chitosan Derivatives (With Cationic and Anionic Substituents)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Mikušová

Mikuš

2021

IJMS

244

120

View full text Add to dashboard Cite

show abstract

“…In recent years chitosan, an abundant natural polysaccharide obtained from crustacean exoskeletons has been extensively studied for drug delivery applications in the form of micro and nanoparticles, (Sinha et al 2004, Hu et al 2007Papadimitriou et al 2008;Bernkop-Schnürch & Dünnhaupt 2012;Tian et al 2016;Kong et al 2017). Chitosan has been studied for tissue engineering (Hua et al 2008, Bhardwaj et al 2011Sivashankari et al 2016) and wound healing (Bae et al 2009;Bano et al 2017) applications.…”

Section: Introductionmentioning

confidence: 99%

Novel Chitosan Microparticles for Sequestration of Overdosed Drug

Chakraborty

Agbayani

Chua

2017

KIMIKA

View full text Add to dashboard Cite

Chitosan microparticles were synthesized by crosslinking chitosan and glycidyl trimethylammonium chloride modified chitosan inside the reverse micelles of Span and Tween 80. The particles were of uniform size with the average diameter of 10 μm. The particles swelled almost twice the original size in 20 min when dispersed in a buffer solution of pH 7.4. The feasibility of chitosan microparticles as drug sequestrant was tested using propafenone as the model drug. The particles sequestered free propafenone from a buffer solution of pH 7.4. In 20 min unmodified chitosan and modified chitosan microparticles sequestered 53% and 51.5% of the free drug respectively. The amount of drug sequestered increased with increase in the initial free drug concentration. The presence of normal saline also improved propafenone sequestration.

show abstract

Chitosan-based nanomaterials on controlled bioactive agents delivery: a review

Velásquez¹

2018

JAPLR

View full text Add to dashboard Cite

This paper presents fundamental aspects related to the biopolymer chitosan, describing briefly the main chemical and structural characteristics that confer it its striking properties, especially those related to their bioactivity. Subsequently, some of the most common methods for the preparation of nanomaterials based on this biopolymer are summarized and briefly outlined some of its applications in the controlled release of biologically active agents. Exposed material allows have a general vision on the new and potential applications on controlled drug released that continue appearing for the chitosan and its derivatives -that seem to have no limits-in spite of having been on the scene for a long time.Citation: Velásquez CL. Chitosan-based nanomaterials on controlled bioactive agents delivery: a review.Citation: Velásquez CL. Chitosan-based nanomaterials on controlled bioactive agents delivery: a review.

show abstract

Chitosan and its derivatives-based nano-formulations in drug delivery

Cited by 3 publications

References 280 publications

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Advances in Chitosan-Based Nanoparticles for Drug Delivery

Novel Chitosan Microparticles for Sequestration of Overdosed Drug

Chitosan-based nanomaterials on controlled bioactive agents delivery: a review

Contact Info

Product

Resources

About