Chitosan and glyceryl monooleate nanostructures containing gallic acid isolated from amla fruit: targeted delivery system

Abstract

Gallic acid, active constituent of amla fruit its natural abundance with beneficial multi actions in body make them attractive for clinical applications. In present study, we focused on extracting, separating and characterizing gallic acid from amla and further formulated into chitosan nanoparticles, so bring it to increase its aqueous solubility and thereby bioactivity. Gallic acid nanoparticles were prepared by using poloxamer 407, chitosan and Glyceryl Monooleate (GMO) using probe sonicator and high pressure homogenization method. Prepared nanoparticles were characterized by particle size, zeta potential, DSC, XRD, SEM, entrapment efficiency, loading content, in-vitro release and stability study. They showed approximately 76.80% encapsulation of gallic acid with average size of 180.8 ± 0.21 nm, and zeta potential + 24.2 mV. The cumulative in vitro drug release upto 24 hrs 77.16% was achieved suggesting that from all our findings, it can be concluded that work will facilitate extraction, design and fabrication of nanoparticles for protection and sustained release of gallic acid particularly to colonic region.

Functionalized SnO2 nanoparticles with gallic acid via green chemical approach for enhanced photocatalytic degradation of citalopram: synthesis, characterization and application to pharmaceutical wastewater treatment

“…Also, some peaks for GA had appeared at 2Ɵ = 15.35°, 17.23° and 21.85°. This reflected the successful modification of the surface of SnO 2 NP and confirmed the functionalization of SnO 2 NP with GA (Hu et al 2013 ; Patil and Killedar 2021 ). BET analysis revealed that the surface area and pore radius were 28.35 m 2 /g and 1.92 nm, respectively with total pore volume of 0.72 cc/g.…”

pH-Responsive Hybrid Nanoassemblies for Cancer Treatment: Formulation Development, Optimization, and In Vitro Therapeutic Performance

“…Both empty LNLCs and DOX-LNLC contain -C-O groups, but their assignment is slightly different permitting to identify the drug component ( Figure 8 B, Vs(C-O)). P407 has several ether groups that appear at lower frequencies (1100 cm −1 ), whereas in the case of DOX, the -C-O group is part of the ester bond (O-C=O) and thus appears more intense at higher frequencies ( Figure 8 B, Vs(C-O)) [ 55 , 58 ]. At roughly the same frequencies and probably superimposed are the stretching modes of the hydroxyl groups from GMO (–C–OH β at ≈1116 cm −1 and –C–OH γ at ≈1150 cm −1 ) ( Figure 8 B).…”

Nanometer-Thick Gallic Acid Coatings Enhance the Electrochemical Performance of Silicon Anodes

“…CV measurements were performed to study the lithiation–delithiation behavior of the three electrodes for two cycles at a scan rate of 0.1 mV s –1 , and the results are shown in Figure a,b). The bare nano-Si electrode showed cathodic peaks around 0.77 V, which was attributed to the decomposition of the electrolyte and the generation of the SEI film, resulting in a large irreversible capacity. However, it is not so obvious for the nano-Si@GA-1 (m Si /m GA = 10:1) electrode (Figure b).…”

“…The results demonstrate that the structure of Si particles were not affected by GA-coating. Moreover, new peaks have been found at 16, 26, 27, and 32°f or nano-Si@GA-1 and nano-Si@GA-2, which are consistent with the spectrum of pure GA. 35 To evaluate the cross-linking structure of GA containing a large number of −COOH and −OH groups on surface of the Si particles, FTIR analysis has been performed. As seen in Figure 1h, the broad band around 3400 cm −1 corresponds to the stretching vibration of the −OH groups on the silicon surface.…”