Chitosan/alginate bionanocomposites adorned with mesoporous silica nanoparticles for bone tissue engineering

Yousefiasl, Satar; Manoochehri, Hamed; Makvandi, Pooyan; Afshar, Saeid; Salahinejad, E.; Khosraviyan, Pegah; Saidijam, Massoud; Asl, Sara Soleimani; Sharifi, Esmaeel

doi:10.1007/s40097-022-00507-z

Cited by 25 publications

(13 citation statements)

References 40 publications

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“…An efficient factor in improving the performance of tissue engineering is the ability to prevent bacterial infection. , Figure c presents the zones of bacterial inhibition formed around the disks and shows the antibacterial response against both Gram-positive S. aureus and Gram-negative E.…”

Section: Resultsmentioning

confidence: 99%

“…An efficient factor in improving the performance of tissue engineering is the ability to prevent bacterial infection. 59,60 Figure 7c presents the zones of bacterial inhibition formed around the disks and shows the antibacterial response against both Gram-positive S. aureus and Gram-negative E. coli bacteria in the presence of the TSX antibiotic as a positive control. Against E. coli bacteria, the PU/ Cur-SC4A-LDH nanocomposite film displayed the best antibacterial activity with an inhibition zone of 1.83 cm compared to the antibiotic (1.72 cm), PU/Cur-LDH (1.51 cm), and PU/LDH (1.35 cm).…”

Section: Sem and Eds Studymentioning

confidence: 99%

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Antibacterial Host–Guest Intercalated LDH-Adorned Polyurethane for Accelerated Dermal Wound Healing

Mohammadi

Abdolvand

Najafabadi

et al. 2022

ACS Appl. Bio Mater.

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Curcumin has a limited clinical application because of its extremely poor accessibility. In the present study, improved curcumin bioavailability within a castor oil polyurethane/layered double hydroxide (LDH) wound cover was achieved by preparing a curcumin p-sulfonic acid calix[4]arene (SC4A) inclusion complex. Then, it was utilized to intercalate MgAl–layered double hydroxide (MgAl-LDH) nanosheets. The incorporation of the nanostructure into a PU/Cur-SC4A-LDH film provided bacteria-killing performance against both Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli bacteria. This finding is due to an increase in curcumin bioavailability in the PU matrix. Furthermore, all PU nanocomposites exhibited appropriate cytocompatibility based on an MTT assay. Mainly, the proliferation of L929 fibroblast cells in contact with the PU/Cur-SC4A-LDH sample was significantly further enhanced than that for other nanocomposites within 7 days. This observation can be related to the better availability of curcumin on the film’s surface, which causes an improvement in the proliferation rate of cells. Regarding the histological results, the hematoxylin and eosin (H&E) images showed faster epidermal layer formation and a larger quantity of matured hair follicles for PU/Cur-SC4A-LDH-healed wounds in comparison with those for the negative control over a period of 28 days. Thus, this practical healing ability of the PU/Cur-SC4A-LDH nanocomposite makes it a promising candidate as a wound dressing film.

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Section: Resultsmentioning

confidence: 99%

Section: Sem and Eds Studymentioning

confidence: 99%

Antibacterial Host–Guest Intercalated LDH-Adorned Polyurethane for Accelerated Dermal Wound Healing

Mohammadi

Abdolvand

Najafabadi

et al. 2022

ACS Appl. Bio Mater.

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Section: Discussionmentioning

confidence: 99%

“…Micro and nanoscale carriers have been used for drug delivery applications [ 43 – 49 ]. PLGA-based particles can be used as protein carriers by encapsulation, chemical binding, or simply adsorption of proteins [ 49 – 52 ]. PLGA-particles possess several characteristics including biodegradability, biocompatibility, high safety profile, sustained and controlled release of the encapsulated drugs, and the possibility of surface functionalization [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

PLGA microparticle formulations for tunable delivery of a nano-engineered filamentous bacteriophage-based vaccine: in vitro and in silico-supported approach

et al. 2023

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Bacteriophages have attracted great attention in the bioengineering field in diverse research areas from tissue engineering to therapeutic and clinical applications. Recombinant filamentous bacteriophage, carrying multiple copies of foreign peptides on protein capsid has been successfully used in the vaccine delivery setting, even if their plasma instability and degradation have limited their use on the pharmaceutical market. Encapsulation techniques in polymeric materials can be applied to preserve bacteriophage activity, extend its half-life, and finely regulate their release in the target environment. The main goal of this study was to provide tunable formulations of the bacteriophage encapsulated in polymeric microparticles (MPs). We used poly (lactic-co-glycolic-acid) as a biocompatible and biodegradable polymer with ammonium bicarbonate as a porogen to encapsulate bacteriophage expressing OVA (257–264) antigenic peptide. We demonstrate that nano-engineered fdOVA bacteriophages encapsulated in MPs preserve their structure and are immunologically active, inducing a strong immune response towards the delivered peptide. Moreover, MP encapsulation prolongs bacteriophage stability over time also at room temperature. Additionally, in this study, we show the ability of in silico-supported approach to predict and tune the release of bacteriophages. These results lay the framework for a versatile bacteriophage-based vaccine delivery system that could successfully generate robust immune responses in a sustained manner, to be used as a platform against cancer and new emerging diseases. Graphical abstract Synopsis: administration of recombinant bacteriophage-loaded PLGA microparticles for antigen delivery. PLGA microparticles release the bacteriophages, inducing activation of dendritic cells and enhancing antigen presentation and specific T cell response. Bacteriophage-encapsulated microneedles potentially can be administered into human body and generate robust immune responses.

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“…However, monitoring antibiotic concentration increases the efficacy of treating infections by altering the dose of administered drugs (Figure 6). 75,76 Microneedlebased biosensors have gained attention among the research community for transdermal collection of biofluids and/or detection of various analytes in a minimally invasive manner. 74 There are different methods to fabricate an IL-based electrochemical sensor.…”

Section: Concluding Remarks and Perspectivementioning

confidence: 99%

Ionic liquid‐based materials for electrochemical biosensing

Khorsandi

Zarepour

Rezazadeh

et al. 2022

Clinical and Translational Dis

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Due to their interesting features including negligible volatility, ease of designing in the construction, good chemical, and thermal stabilities, and excellent ionic conductivity, ionic liquids (ILs) have attracted a lot of attention to themselves in recent years. They are constructed from asymmetric anions and cations and are found in a liquid state lower than 100 • C. Their unique features introduce them as candidates for the application in the structure of different types of electrochemical biosensors, in which they could act as electrolytes, or could be used

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Chitosan/alginate bionanocomposites adorned with mesoporous silica nanoparticles for bone tissue engineering

Cited by 25 publications

References 40 publications

Antibacterial Host–Guest Intercalated LDH-Adorned Polyurethane for Accelerated Dermal Wound Healing

Antibacterial Host–Guest Intercalated LDH-Adorned Polyurethane for Accelerated Dermal Wound Healing

PLGA microparticle formulations for tunable delivery of a nano-engineered filamentous bacteriophage-based vaccine: in vitro and in silico-supported approach

Ionic liquid‐based materials for electrochemical biosensing

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