Chitosan: A versatile bio-platform for breast cancer theranostics

Madamsetty, Vijay Sagar; Tavakol, Shima; Moghassemi, Saeid; Dadashzadeh, Arezoo; Schneible, John D.; Fatemi, Iman; Shirvani, Abdolsamad; Zarrabi, Ali; Azedi, Fereshteh; Dehshahri, Ali; Afshar, Abbas Aghaei; Aghaabbasi, Kian; Pardakhty, Abbas; Mohammadinejad, Reza; Kesharwani, Prashant

doi:10.1016/j.jconrel.2021.12.012

Cited by 49 publications

(22 citation statements)

References 359 publications

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“…Polycationic compounds can be considered as highly tailored gene delivery platforms, encouraging researchers to produce a new library of polycationic compounds for potential application in human trials. Several polycationic polymers have been investigated for non-viral gene delivery, including polyethylenimine (PEI) [ 13 , 14 ], polypropylenimine (PPI) [ 15 ], polyamidoamide (PAMAM) [ 16 ], and chitosan (CS) [ 17 , 18 , 19 , 20 ]. In recent decades, considering the safety, cytocompatibility, and gene transfer efficiency, CS has been considered one of the most investigated non-viral polycationic compounds for gene delivery [ 17 , 18 , 19 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…Several polycationic polymers have been investigated for non-viral gene delivery, including polyethylenimine (PEI) [ 13 , 14 ], polypropylenimine (PPI) [ 15 ], polyamidoamide (PAMAM) [ 16 ], and chitosan (CS) [ 17 , 18 , 19 , 20 ]. In recent decades, considering the safety, cytocompatibility, and gene transfer efficiency, CS has been considered one of the most investigated non-viral polycationic compounds for gene delivery [ 17 , 18 , 19 , 21 ]. Despite the potential for gene transfer purposes, CS has not made great achievements in human clinical trials, which might be due to its insolubility and the low stability of CS-based particles at physiological pH.…”

Section: Introductionmentioning

confidence: 99%

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Interleukin-12 Plasmid DNA Delivery by N-[(2-Hydroxy-3-trimethylammonium)propyl]chitosan-Based Nanoparticles

et al. 2022

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Cationic polysaccharides are capable of forming polyplexes with nucleic acids and are considered promising polymeric gene carriers. The objective of this study was to evaluate the transfection efficiency and cytotoxicity of N-[(2-hydroxy-3-trimethylammonium)propyl] chitosan salt (HTCS), a quaternary ammonium derivative of chitosan (CS), which benefits from non-ionizable positive charges. In this work, HTCS with a full quaternization of amino groups and a molar mass of 130,000 g·mol−1 was synthesized to use for delivery of a plasmid encoding the interleukin-12 (IL-12) gene. Thus, a polyplex based on HTCS and the IL-12 plasmid was prepared and then was characterized in terms of particle size, zeta potential, plasmid condensation ability, and protection of the plasmid against enzymatic degradation. We showed that HTCS was able to condense the IL-12 plasmid by the formation of polyplexes in the range of 74.5 ± 0.75 nm. The level of hIL-12 production following the transfection of the cells with HTCS polyplexes at a C/P ratio of 8:1 was around 4.8- and 2.2-fold higher than with CS and polyethylenimine polyplexes, respectively. These findings highlight the role of HTCS in the formation of polyplexes for the efficient delivery of plasmid DNA.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Interleukin-12 Plasmid DNA Delivery by N-[(2-Hydroxy-3-trimethylammonium)propyl]chitosan-Based Nanoparticles

et al. 2022

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“…Chitosan (CS), as one of the most abundant natural macromolecules, has received considerable attention for its high biosafety, low immunogenicity, excellent biocompatibility, admirable biodegradability, and versatile biological activities [1][2][3][4][5][6][7][8][9]. In addition, CS is the only natural cationic polymer.…”

Section: Introductionmentioning

confidence: 99%

Dually Responsive Nanoparticles for Drug Delivery Based on Quaternized Chitosan

Qiao

Jiang

Fang

et al. 2022

IJMS

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In this work, we report the fabrication and functional demonstration of a kind of dually responsive nanoparticles (NPs) as a potential drug delivery vector. The pH value, corresponding to the acidic microenvironment at the tumor site, and mannitol, to the extracellular trigger agent, were employed as the dually responsive factors. The function of dual responses was achieved by breaking the dynamic covalent bonds between phenylboronic acid (PBA) groups and diols at low pH value (pH 5.0) and/or under the administration of mannitol, which triggered the decomposition of the complex NPs and the concomitant release of anticancer drug of doxorubicin (DOX) loaded inside the NPs. The NPs were composed of modified chitosan (PQCS) with quaternary ammonium and PBA groups on the side chains, heparin (Hep), and poly(vinyl alcohol) (PVA), in which quaternary ammonium groups offer the positive charge for the cell-internalization of NPs, PBA groups serve for the formation of dynamic bonds in responding to pH change and mannitol addition, PVA furnishes the NPs with diol groups for the interaction with PBA groups and the formation of dynamic NPS, and Hep plays the roles of reducing the cytotoxicity of highly positively-charged chitosan and forming of complex NPs for DOX up-loading. A three-step fabrication process of drug-loaded NPs was described, and the characterization results were comprehensively demonstrated. The sustained drug release from the drug-loaded NPs displayed obvious pH and mannitol dependence. More specifically, the cumulative DOX release was increased more than 1.5-fold at pH 5.0 with 20 mg mL−1 mannitol. Furthermore, the nanoparticles were manifested with effective antitumor efficient and apparently enhanced cytotoxicity in response to the acidic pH value and/or mannitol.

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“… 296 It is obtained by alkaline deacetylation of chitin, the second most abundant polysaccharide in nature. 297 , 298 Among its properties, biocompatibility, biodegradability, and nontoxicity are the most attractive, while antimicrobial activity and muco-adhesiveness add additional advantages. 299 − 302 DEX-loaded chitosan-coated BSA polydopamine-layered NPs provide the potential to modify adhesive and transferable free-standing films.…”

Section: Dexamethasone Delivery Systemsmentioning

confidence: 99%

Dexamethasone: Insights into Pharmacological Aspects, Therapeutic Mechanisms, and Delivery Systems

Madamsetty

Mohammadinejad

Uzielienè

et al. 2022

ACS Biomater. Sci. Eng.

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Dexamethasone (DEX) has been widely used to treat a variety of diseases, including autoimmune diseases, allergies, ocular disorders, cancer, and, more recently, COVID-19. However, DEX usage is often restricted in the clinic due to its poor water solubility. When administered through a systemic route, it can elicit severe side effects, such as hypertension, peptic ulcers, hyperglycemia, and hydro-electrolytic disorders. There is currently much interest in developing efficient DEX-loaded nanoformulations that ameliorate adverse disease effects inhibiting advancements in scientific research. Various nanoparticles have been developed to selectively deliver drugs without destroying healthy cells or organs in recent years. In the present review, we have summarized some of the most attractive applications of DEX-loaded delivery systems, including liposomes, polymers, hydrogels, nanofibers, silica, calcium phosphate, and hydroxyapatite. This review provides our readers with a broad spectrum of nanomedicine approaches to deliver DEX safely.

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Chitosan: A versatile bio-platform for breast cancer theranostics

Cited by 49 publications

References 359 publications

Interleukin-12 Plasmid DNA Delivery by N-[(2-Hydroxy-3-trimethylammonium)propyl]chitosan-Based Nanoparticles

Interleukin-12 Plasmid DNA Delivery by N-[(2-Hydroxy-3-trimethylammonium)propyl]chitosan-Based Nanoparticles

Dually Responsive Nanoparticles for Drug Delivery Based on Quaternized Chitosan

Dexamethasone: Insights into Pharmacological Aspects, Therapeutic Mechanisms, and Delivery Systems

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