Chitooligosaccharides promote radiosensitivity in colon cancer line SW480

Han, Fushi; Yang, Shengmei; Lin, Moubin; Chen, Ying-Qun; Yang, Ping; Xu, Jun

doi:10.3748/wjg.v22.i22.5193

Cited by 10 publications

(9 citation statements)

References 49 publications

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“…Chitosan oligosaccharide was found to reduce the development of cancer cells, tumor growth, and the metastatic potential of gastric cancer. Interestingly, chitosan oligosaccharide increased the radiosensitivity in colon cancer cells (Fernandes et al 2012;Han et al 2016;Kim et al 2012;Luo et al 2014). Nascimento et al (2014 have studied about the development of epidermal growth factor receptortargeted chitosan (EGFR-targeted chitosan) nanoparticles to Fig.…”

Section: Other Biomedical Applicationsmentioning

confidence: 99%

Marine shell industrial wastes–an abundant source of chitin and its derivatives: constituents, pretreatment, fermentation, and pleiotropic applications-a revisit

Suryawanshi

Jujjavarapu

Seenivasan

2019

Int. J. Environ. Sci. Technol.

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Unscientific dumping of shellfishery waste is a major environmental concern worldwide and a serious threat to the coastal area. The shell wastes constitute of many commercially valuable products, such as, chitin, calcium carbonate, proteins, and carotenoids. Processing of shell wastes is a source of wealth. Chitin is one of the constituents of the shell wastes and also the most abundant biopolymer next to the cellulose. Calcium carbonate and proteins are the other valuable constituents of the shell wastes and can serve as a better animal feed supplement. Extraction of chitin and other valuable products from a complex mixture is cumbersome and requires consecutive pretreatment processes. Both chemical and fermentation routes of pretreatment strategies have been adopted to extract the chitin from the shell wastes, which are critically reviewed with their merits and demerits. The application of process intensification techniques, such as ultrasonication and microwave radiation, is also emphasized along with the recent advancement in the field of pretreatment processes. Pleiotropic industrial applications of chitin and its analogues are also discussed. KeywordsChitin • Crustacean shell waste • Chemical and biological pretreatment methods •

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Section: Other Biomedical Applicationsmentioning

confidence: 99%

Marine shell industrial wastes–an abundant source of chitin and its derivatives: constituents, pretreatment, fermentation, and pleiotropic applications-a revisit

Suryawanshi

Jujjavarapu

Seenivasan

2019

Int. J. Environ. Sci. Technol.

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“…The concentrations of SCFAs and the abundances of Lactobacilli and Bifidobacteria were significantly increased in the cecum of mice treated with COS (Pan et al, 2009). COS are also effective against various cancer cells in vitro , such as prostate, lung, hepatocellular, gastric and colon cancer cells (Park et al, 2011; Han et al, 2015, 2016; Ryu et al, 2017). However, the relationship between the anti-tumor activities of COS and its effects on bacteria in vivo remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Chitooligosaccharides Prevents the Development of Colitis-Associated Colorectal Cancer by Modulating the Intestinal Microbiota and Mycobiota

et al. 2019

Front. Microbiol.

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Gut microbes play a crucial role in the development of colorectal cancer. Chitooligosaccharides (COS), are oligomer that are depolymerized from chitosan and possess a wide range of biological activities. In this study, the effects of COS on colorectal cancer (CRC) development were evaluated using azoxymethane and dextran sulfate sodium (AOM/DSS) induced mouse model of CRC (CACM). In the COS-treated CRC group (CMCOS), COS protected mice from CRC by decreasing the disease activity index, tumor incidences and multiplicity, and the mRNA levels of COX-2, IL-6, TNF-α, IL-1β, IL-10, and IKK-β mRNA in colonic epithelial cells. The results of a cage-exchanged experiment, in which mice from the CACMe and CMCOSe treatments exchanged cages every day to interact with microbes, showed that gut microbes play an important role in preventing CAC by COS. The abundances of fecal bacteria (total bacteria, Lactobacillus, Enterococcus, Fusobacterium nucleatum and butyrate-producing bacteria) were detected by qPCR on the 0th, 1st, 3rd, 6th, 9th, and 10th weekends. Furthermore, microbiota and mycobiota were analyzed by high-throughput sequencing on an Illumina MiSeq PE300 system. COS protected mice from CRC by reversing the imbalance of bacteria and fungi, especially by reducing the abundance of Escherichia–Shigella, Enterococcus, and Turicibacter, and increasing the levels of Akkermansia, butyrate-producing bacteria and Cladosporium.

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“…25,26 The COS have been proven to promote radiosensitivity by accelerating cell apoptosis in colon cancer. 8 However, the underlying molecular mechanisms of COS are rarely mentioned. We first measured the toxicity of COS to SW480 cells, revealing that survival rates decreased significantly as concentrations of COS grew.…”

Section: Anril Expression Was Higher In Colon Cancer Cells With Downr...mentioning

confidence: 99%

“…Chitooligosaccharides (COS) have been reported to be an anticancer factor, which can also raise the radiosensitivity of colon cancer. 8 However, the mechanism of COS in mediating the radiosentivity of colon cancer is unclear. Therefore, functions of COS at the molecular level were explored in this study.…”

Section: Introductionmentioning

confidence: 99%

LncRNA ANRIL negatively regulated chitooligosaccharide-induced radiosensitivity in colon cancer cells by sponging miR-181a-5p

Sun

Shen²,

Zhang

et al. 2021

Adv Clin Exp Med

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Chitooligosaccharides promote radiosensitivity in colon cancer line SW480

Abstract: COS can inhibit the proliferation of SW480 cells and enhance the radiosensitization of SW480 cells, inducing apoptosis and G2/M phase arrest.

Cited by 10 publications

References 49 publications

Marine shell industrial wastes–an abundant source of chitin and its derivatives: constituents, pretreatment, fermentation, and pleiotropic applications-a revisit

Marine shell industrial wastes–an abundant source of chitin and its derivatives: constituents, pretreatment, fermentation, and pleiotropic applications-a revisit

Chitooligosaccharides Prevents the Development of Colitis-Associated Colorectal Cancer by Modulating the Intestinal Microbiota and Mycobiota

LncRNA ANRIL negatively regulated chitooligosaccharide-induced radiosensitivity in colon cancer cells by sponging miR-181a-5p

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