Chitooligosaccharide-europium (III) functional micron complex with visualized inflammation monitoring, immunomodulation and pro-vascularization activities for effective wound healing of pressure ulcers injury

Freeze-drying platforms design for batch fabrication of Haversian system mimicking scaffolds with enhanced osteogenesis

“…After rearing to week 1 (1W)/2W/4W, the rats were anesthetized and the material was taken. The material was processed for hematoxylin-eosin (H&E) staining, Masson’s staining, TRAP staining, immunofluorescence staining, immunohistochemical staining, and micro computed tomography (micro-CT) imaging for observation and evaluation ( Huang et al, 2022 ).…”

Advance in topical biomaterials and mechanisms for the intervention of pressure injury

“…developed the effect of composite material COS-Eu and applied it in PI mice model. 157 With the application of COS-Eu powder at the wound site, more expression of anti-inflammatory factor IL-10 was observed on day 3 and 7, which is in the inflammatory stage. In addition, as Eu emits red fluorescence, the complex was easy to achieve objectively and visually monitoring pH variation.…”

Tumor-microenvironment double-responsive shrinkable nanoparticles fabricated via facile assembly of laponite with a bioactive oligosaccharide for anticancer therapy

“…These stimuli include acidic pH and certain upregulated enzymes in tumors [20,21]. Chitosan oligosaccharides (COS) are water-soluble natural resources with a variety of versatile biological activities, including immunity enhancement and antitumor, skin regeneration, and hemostatic effects [22][23][24][25][26]. Chitosan oligosaccharide (COS) also exhibits a variety of features suitable for drug delivery [27,28].…”