Chitinases as Food Allergens

Leoni, Claudia; Volpicella, Mariateresa; Dileo, Maria C.G.; Gattulli, B.; Ceci, Luigi R.

doi:10.3390/molecules24112087

Cited by 32 publications

(22 citation statements)

References 46 publications

(38 reference statements)

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“…Plant chitinases are also a well-known group of food allergens. It is a relatively small group, but it is present in highly consumed fruits [75]. Chitinases can be divided into five classes (I-V), and plant class III chitinases (PR-8 proteins) have an additional lysozyme activity, which is not found in other classes of chitinases [76].…”

Section: Chitinase III As Allergen In Raspberrymentioning

confidence: 99%

Transferability and Polymorphism of SSR Markers Located in Flavonoid Pathway Genes in Fragaria and Rubus Species

Lebedev

Subbotina

Maluchenko

et al. 2019

Genes

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Strawberry (Fragaria) and raspberry (Rubus) are very popular crops, and improving their nutritional quality and disease resistance are important tasks in their breeding programs that are becoming increasingly based on use of functional DNA markers. We identified 118 microsatellite (simple sequence repeat-SSR) loci in the nucleotide sequences of flavonoid biosynthesis and pathogenesis-related genes and developed 24 SSR markers representing some of these structural and regulatory genes. These markers were used to assess the genetic diversity of 48 Fragaria and Rubus specimens, including wild species and rare cultivars, which differ in berry color, ploidy, and origin. We have demonstrated that a high proportion of the developed markers are transferable within and between Fragaria and Rubus genera and are polymorphic. Transferability and polymorphism of the SSR markers depended on location of their polymerase chain reaction (PCR) primer annealing sites and microsatellite loci in genes, respectively. High polymorphism of the SSR markers in regulatory flavonoid biosynthesis genes suggests their allelic variability that can be potentially associated with differences in flavonoid accumulation and composition. This set of SSR markers may be a useful molecular tool in strawberry and raspberry breeding programs for improvement anthocyanin related traits.

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Section: Chitinase III As Allergen In Raspberrymentioning

confidence: 99%

Transferability and Polymorphism of SSR Markers Located in Flavonoid Pathway Genes in Fragaria and Rubus Species

Lebedev

Subbotina

Maluchenko

et al. 2019

Genes

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“…Zhao et al [ 19 ] indicated chitinase and paramyosin as two other potential allergens. Chitinase has already been discussed as an allergen between different species, especially in plant kingdom, like fruits [ 42 ]. AK from silkworm (SW) is of particular relevance because it is the only allergen (Bomb m 1) from edible insects officially accepted as food allergen ( www.allergen.org ) and included in the IUIS allergen database.…”

Section: Cross-reactivity and Primary Sensitizationmentioning

confidence: 99%

Allergens from Edible Insects: Cross-reactivity and Effects of Processing

Marchi

Wangorsch

Zoccatelli

2021

Curr Allergy Asthma Rep

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Purpose of Review The recent introduction of edible insects in Western countries has raised concerns about their safety in terms of allergenic reactions. The characterization of insect allergens, the sensitization and cross-reactivity mechanisms, and the effects of food processing represent crucial information for risk assessment. Recent Findings Allergic reactions to different insects and cross-reactivity with crustacean and inhalant allergens have been described, with the identification of new IgE-binding proteins besides well-known pan-allergens. Depending on the route of sensitization, different potential allergens seem to be involved. Food processing may affect the solubility and the immunoreactivity of insect allergens, with results depending on species and type of proteins. Chemical/enzymatic hydrolysis, in some cases, abolishes immunoreactivity. Summary More studies based on subjects with a confirmed insect allergy are necessary to identify major and minor allergens and the role of the route of sensitization. The effects of processing need to be further investigated to assess the risk associated with the ingestion of insect-containing food products.

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“…These findings indicate that further efforts are still needed to achieve a robust characterization of allergenic chitinases (and also of all the other allergens). 17…”

Section: Characterization Of Allergensmentioning

confidence: 99%

Recombinant Allergens in Immunotherapy of Asthma

Farsani

Yaghubi-tabar

Farsani

2020

J. Contemp. Med. Sci.

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Asthma is a chronic inflammatory disorder caused by T-cell-mediated inflammation within airways. The prevalence of allergic diseases is rapidly increasing so that knowing allergens (characterization and types) and strategies for asthma management, prevention and treatment are very important. The most strategy is the production of recombinant allergens. Many of the problems associated with using natural allergenic products for allergy diagnosis and treatment can be overcome with the use of genetically engineered recombinant allergens. Various recombinant allergens are now emerging as strong candidates for allergen-specific immunotherapy. Extrinsic asthma (a type of asthma) may respond to immunotherapy such as using recombinant allergens. These exciting novel therapies provide not only the promise of new therapies for asthma but also valuable tools for the investigation of asthma mechanisms. This review describes strategies for asthma management, prevention and treatment, and especially recombinant allergens and also recent progresses in the molecular biology of recombinant allergens and then advantage and disadvantage of these allergens are explained. There are many methods for producing allergens such as extraction of serum, Ro/SS-A anti-Ro/SS-A system, Using the Solid-Phase Immunoadsorption system and finally recombinant technology for producing recombinant allergens. Recombinant allergens can express in many systems such as bacteria, yeast, insect cells, animal cells, and transgenic plant. We describe recombinant allergens produced in these systems. The obtained results hold promise that recombinant allergen–based immunotherapy will improve current immunotherapy practice and may open possibilities for new treatment strategies and possibly even for prophylactic vaccination.

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Chitinases as Food Allergens

Cited by 32 publications

References 46 publications

Transferability and Polymorphism of SSR Markers Located in Flavonoid Pathway Genes in Fragaria and Rubus Species

Transferability and Polymorphism of SSR Markers Located in Flavonoid Pathway Genes in Fragaria and Rubus Species

Allergens from Edible Insects: Cross-reactivity and Effects of Processing

Recombinant Allergens in Immunotherapy of Asthma

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