Chitinase inhibition induces transcriptional dysregulation altering ecdysteroid-mediated control of Spodoptera frugiperda development

Barbole, Ranjit S.; Sharma, Shivani; Patil, Yogita; Giri, Ashok P.; Joshi, Rakesh S.

doi:10.1016/j.isci.2024.109280

Cited by 2 publications

(1 citation statement)

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“…A disorder in TRE1 metabolism can lead to a series of morphological abnormalities in insects, including pupation deformity or failure, molting difficulties, wing-spreading difficulties, or wing-shape abnormalities. TRE2 mainly affects the gene expression of chitin synthase and the chitin content in the mid-gut of larvae [50], thereby presenting a promising avenue for the development of efficacious pest-control interventions.…”

Section: Discussionmentioning

confidence: 99%

Effect of Three Novel Thiazolidiones on the Development, Reproduction, and Trehalase Activity of Spodoptera frugiperda (Lepidoptera: Noctuidae)

Yu,

Zhong,

Jiang

et al. 2024

Agronomy

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Spodoptera frugiperda was used to investigate its role as a trehalase inhibitor of three new thiothiazolidone compounds—6d, 6e, and 6f. The development and reproduction of S. frugiperda were investigated to evaluate the potential of these compounds as a novel pesticide for pest control. Compounds 6d, 6e, and 6f were injected into larvae and female pupae. Molecular changes in trehalose and chitin metabolism genes were monitored. Pupal trehalase activity, the female pupal emergence rate, ovarian development, and SfVg and SfVgR gene expression levels were assessed. The results revealed that all three compounds significantly inhibited trehalase activity in the larvae. The expression of TRE was significantly downregulated, and compounds 6d and 6f significantly downregulated the expression of TRE2. Treated larvae exhibited significantly decreased survival rates and a higher incidence of abnormalities. The egg production and hatching rates were markedly diminished by the inhibitors, and the ovaries displayed blackening and clumping. These compounds exhibit promise as eco-friendly insecticides, but further experiments are required to test their multifaceted capabilities.

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Section: Discussionmentioning

confidence: 99%