Chitin of Araneae origin: structural features and biomimetic applications: a review

Machałowski, Tomasz; Amemiya, Chris T.; Jesionowski, Teofil

doi:10.1007/s00339-020-03867-x

Cited by 11 publications

(8 citation statements)

References 134 publications

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“…As an example, Baldino et al described an innovative method of producing alginate-chitosan aerogels for biomedical application through supercritical drying [ 3 ]. As observed, chitin has also been intensively developed with respect to biomedical engineering application [ 4 , 5 , 6 , 7 , 8 ]. Thanks to its abundance and extraordinary features, such as biocompatibility and biodegradability, this biopolymer is used in the fields of tissue engineering (TE) [ 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Naturally Formed Chitinous Skeleton Isolated from the Marine Demosponge Aplysina fistularis as a 3D Scaffold for Tissue Engineering

et al. 2021

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Tissue engineering (TE) is a field of regenerative medicine that has been experiencing a special boom in recent years. Among various materials used as components of 3D scaffolds, naturally formed chitinous materials seem to be especially attractive because of their abundance, non-toxic and eco-friendly character. In this study, chitinous skeleton isolated from the marine sponge Aplysina fistularis (phylum: Porifera) was used for the first time as a support for the cultivation of murine fibroblasts (Balb/3T3), human dermal fibroblasts (NHDF), human keratinocyte (HaCaT), and human neuronal (SH-SY5Y) cells. Characterization techniques such as ATR FTIR, TGA, and μCT, clearly indicate that an interconnected macro-porous, thermostable, pure α-chitin scaffold was obtained after alkali–acid treatment of air-dried marine sponge. The biocompatibility of the naturally formed chitin scaffolds was confirmed by cell attachment and proliferation determined by various microscopic methods (e.g., SEM, TEM, digital microscopy) and specific staining. Our observations show that fibroblasts and keratinocytes form clusters on scaffolds that resemble a skin structure, including the occurrence of desmosomes in keratinocyte cells. The results obtained here suggest that the chitinous scaffold from the marine sponge A. fistularis is a promising biomaterial for future research about tissues regeneration.

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Section: Introductionmentioning

confidence: 99%

Naturally Formed Chitinous Skeleton Isolated from the Marine Demosponge Aplysina fistularis as a 3D Scaffold for Tissue Engineering

et al. 2021

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“…The progressive development of supports consisting of biodegradable, non-toxic, biocompatible, and available in large quantity biopolymers represents another answer to the problem of environmental sustainability [ 99 ]. Within this field lignin, collagen, wool, alginates, cellulose, and chitosan are among the most studied sources [ 100 , 101 , 102 ]. The latter is a derivative of chitin, a polysaccharide of N -acetyl- d -glucos-2-amine, held together by β(1-4)glycosidic bonds.…”

Section: Heterogenization Of Iron Compounds On Chitosanmentioning

confidence: 99%

Bringing Homogeneous Iron Catalysts on the Heterogeneous Side: Solutions for Immobilization

et al. 2021

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Noble metal catalysts currently dominate the landscape of chemical synthesis, but cheaper and less toxic derivatives are recently emerging as more sustainable solutions. Iron is among the possible alternative metals due to its biocompatibility and exceptional versatility. Nowadays, iron catalysts work essentially in homogeneous conditions, while heterogeneous catalysts would be better performing and more desirable systems for a broad industrial application. In this review, approaches for heterogenization of iron catalysts reported in the literature within the last two decades are summarized, and utility and critical points are discussed. The immobilization on silica of bis(arylimine)pyridyl iron complexes, good catalysts in the polymerization of olefins, is the first useful heterogeneous strategy described. Microporous molecular sieves also proved to be good iron catalyst carriers, able to provide confined geometries where olefin polymerization can occur. Same immobilizing supports (e.g., MCM-41 and MCM-48) are suitable for anchoring iron-based catalysts for styrene, cyclohexene and cyclohexane oxidation. Another excellent example is the anchoring to a Merrifield resin of an FeII-anthranilic acid complex, active in the catalytic reaction of urea with alcohols and amines for the synthesis of carbamates and N-substituted ureas, respectively. A SILP (Supported Ionic Liquid Phase) catalytic system has been successfully employed for the heterogenization of a chemoselective iron catalyst active in aldehyde hydrogenation. Finally, FeIII ions supported on polyvinylpyridine grafted chitosan made a useful heterogeneous catalytic system for C–H bond activation.

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“…The advantages as well as challenges of chitinous materials include the isolation process and cryopreservation [13,14]. Machalowski et al recently described moulting cuticles of spiders as an alternative source of naturally occurring chitin [15]. Finally, to highlight human-derived scaffolds, decellularized tissues have been utilized in regenerative/tissue engineering medical applications.…”

Section: Introductionmentioning

confidence: 99%

Combining Biocompatible and Biodegradable Scaffolds and Cold Atmospheric Plasma for Chronic Wound Regeneration

Emmert

Pantermehl

Foth

et al. 2021

IJMS

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Skin regeneration is a quite complex process. Epidermal differentiation alone takes about 30 days and is highly regulated. Wounds, especially chronic wounds, affect 2% to 3% of the elderly population and comprise a heterogeneous group of diseases. The prevailing reasons to develop skin wounds include venous and/or arterial circulatory disorders, diabetes, or constant pressure to the skin (decubitus). The hallmarks of modern wound treatment include debridement of dead tissue, disinfection, wound dressings that keep the wound moist but still allow air exchange, and compression bandages. Despite all these efforts there is still a huge treatment resistance and wounds will not heal. This calls for new and more efficient treatment options in combination with novel biocompatible skin scaffolds. Cold atmospheric pressure plasma (CAP) is such an innovative addition to the treatment armamentarium. In one CAP application, antimicrobial effects, wound acidification, enhanced microcirculations and cell stimulation can be achieved. It is evident that CAP treatment, in combination with novel bioengineered, biocompatible and biodegradable electrospun scaffolds, has the potential of fostering wound healing by promoting remodeling and epithelialization along such temporarily applied skin replacement scaffolds.

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Chitin of Araneae origin: structural features and biomimetic applications: a review

Cited by 11 publications

References 134 publications

Naturally Formed Chitinous Skeleton Isolated from the Marine Demosponge Aplysina fistularis as a 3D Scaffold for Tissue Engineering

Naturally Formed Chitinous Skeleton Isolated from the Marine Demosponge Aplysina fistularis as a 3D Scaffold for Tissue Engineering

Bringing Homogeneous Iron Catalysts on the Heterogeneous Side: Solutions for Immobilization

Combining Biocompatible and Biodegradable Scaffolds and Cold Atmospheric Plasma for Chronic Wound Regeneration

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