Chitin, Chitosan, and Silk Fibroin Electrospun Nanofibrous Scaffolds: A Prospective Approach for Regenerative Medicine

Singh, Bhawna; Dutta, Pradip Kumar

doi:10.1007/978-81-322-2511-9_7

Cited by 12 publications

(4 citation statements)

References 180 publications

(190 reference statements)

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“…Chitosan is a biopolymer known for its hemostatic properties, which can be attributed to its ability to create artificial clots when it comes into contact with blood. Chitosan induces platelet adhesion, aggregation and activates intrinsic blood coagulation [95]. The hemostatic mechanism of chitosan involves the agglutination of erythrocytes of the classical coagulation system; in other words, the positively charged structure of chitosan attracts the negatively charged red cells, leading to the appearance of the phenomenon of agglutination and, therefore, coagulation [96].…”

Section: Discussionmentioning

confidence: 99%

Biocompatibility of Membranes Based on a Mixture of Chitosan and Lythri herba Aqueous Extract

Iancu,

Schröder,

Apetroaei

et al. 2023

Applied Sciences

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In the current context of concern for the improvement and protection of environmental conditions, emphasis is placed on the provision of non-toxic, eco-friendly, renewable biomaterials to replace established chemical substances. Lythri herba is the aerial part of the plant species Lythrum salicaria L., known in the scientific literature especially for its content of tannins and total polyphenols, which highlight its antioxidant, hemostatic, antibacterial and antidiarrheal properties. Chitosan is a biopolymer widely used in industry and medicine due to its abundance in nature, its biodegradability, lack of toxicity and the ease with which it can be transformed into several basic forms (hydrogel, membrane, sponge). The aqueous solutions and membranes obtained in this study by merging these two natural resources were biologically tested in terms of genotoxicity (SOS-Chromo assay), hemolytic activity, thrombin generation activity and bacterial adhesion to reveal outwardly the lack of these properties and their use for medical purposes. The results of the current study attest to the absence of mutagenic and slight hemolyzing properties, thus supporting the possibility of using this extract and membrane in medical and pharmaceutical therapeutic practice. The surface parameters of membranes were examined and important influences at thrombin activity were found. Also, bacterial adhesion results showed a correlation between Lythri herba and chitosan concentrations and membranes’ appearances (swelling, stability). The results show that the membranes could be a promising material for biomedical applications.

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Section: Discussionmentioning

confidence: 99%

Biocompatibility of Membranes Based on a Mixture of Chitosan and Lythri herba Aqueous Extract

Iancu,

Schröder,

Apetroaei

et al. 2023

Applied Sciences

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“…It is preferable to use non-toxic solvents to obtain SF fibrous matrices for tissue engineering by electrospinning [31][32][33]. When using aqueous solutions, the most important factor determining the possibility of molding is the concentration of the solution [34,35].…”

Section: Effect Of Silk Fibroin Solution Concentration On Fibrous Mat...mentioning

confidence: 99%

Approaches to Obtaining Water-Insoluble Fibrous Matrices from Regenerated Fibroin

Kildeeva,

Sazhnev,

Drozdova

et al. 2023

Technologies

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Silk fibroin (SF) holds promise for the preparation of matrices for tissue engineering and regenerative medicine or for the development of drug delivery systems. Regenerated fibroin from Bombyx mori cocoons is water-soluble and can be processed into scaffolds of various forms, such as fibrous matrices, using the electrospinning method. In the current study, we studied the correlation between concentrations of fibroin aqueous solutions and their properties, in order to obtain electrospun mats for tissue engineering. Two methods were used to prevent solubility in fibroin-based matrices: The conversion of fibroin to the β-conformation via treatment with an ethanol solution and chemical cross-linking with genipin (Gp). The interaction of Gp with SF led to the appearance of a characteristic blue color but did not lead to the gelation of solutions. To speed up the cross-linking reaction with Gp, we propose using chitosan-containing systems and modifying fibrous materials via treatment with a solution of Gp in 80% ethanol. It was shown that the composition of fibroin with chitosan contributes to an improved water resistance, reduces defective material, and leads to a decrease in the diameter of the fibers. The electrospun fiber matrices based on regenerated fibroin modified by cross-linking with genipin in water–alcohol solutions were shown to promote cell adhesion, spreading, and growth and, therefore, could hold promise for tissue engineering.

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“…High open porous structure, compatible mechanical strength, biodegradability and biocompatibility of electrospun scaffolds promote them as optimal microenvironment for cell proliferation, migration, differentiation, and guidance for cellular in growth at host tissue. Moreover, electrospinning can produce nanofibrous scaffolds that are highly desirable for wound dressing, drug delivery, tissue engineering and other biomedical applications [140,144,145]. …”

Section: Applications Of Ceramic Electrospun Matsmentioning

confidence: 99%

Electrospun Ceramic Nanofiber Mats Today: Synthesis, Properties, and Applications

2017

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Ceramic nanofibers (NFs) have recently been developed for advanced applications due to their unique properties. In this article, we review developments in electrospun ceramic NFs with regard to their fabrication process, properties, and applications. We find that surface activity of electrospun ceramic NFs is improved by post pyrolysis, hydrothermal, and carbothermal processes. Also, when combined with another surface modification methods, electrospun ceramic NFs result in the advancement of properties and widening of the application domains. With the decrease in diameter and length of a fiber, many properties of fibrous materials are modified; characteristics of such ceramic NFs are different from their wide and long (bulk) counterparts. In this article, electrospun ceramic NFs are reviewed with an emphasis on their applications as catalysts, membranes, sensors, biomaterials, fuel cells, batteries, supercapacitors, energy harvesting systems, electric and magnetic parts, conductive wires, and wearable electronic textiles. Furthermore, properties of ceramic nanofibers, which enable the above applications, and techniques to characterize them are briefly outlined.

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Chitin, Chitosan, and Silk Fibroin Electrospun Nanofibrous Scaffolds: A Prospective Approach for Regenerative Medicine

Cited by 12 publications

References 180 publications

Biocompatibility of Membranes Based on a Mixture of Chitosan and Lythri herba Aqueous Extract

Biocompatibility of Membranes Based on a Mixture of Chitosan and Lythri herba Aqueous Extract

Approaches to Obtaining Water-Insoluble Fibrous Matrices from Regenerated Fibroin

Electrospun Ceramic Nanofiber Mats Today: Synthesis, Properties, and Applications

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