Chitin-Based Double-Network Hydrogel as Potential Superficial Soft-Tissue-Repairing Materials

Huang, Junchao; Frauenlob, Martin; Shibata, Yuki; Wang, Lei; Nakajima, Tasuku; Nonoyama, Takayuki; Tsuda, Masayuki; Tanaka, Shinya; Kurokawa, Takayuki; Gong, Jian Ping

doi:10.1021/acs.biomac.0c01003

Cited by 42 publications

(22 citation statements)

References 92 publications

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“…The PAA/0.25NCT hydrogel displayed two peaks at 1696 and 1613 cm –1 , which indicated the metal-coordination interactions between the carboxyl groups and Al 3+ bonds. Moreover, the peaks centered around 3100 cm –1 indicated the presence of the hydrogen bonds between PAA and chitin . The peaks located at 1030 and 1070 cm –1 in the FTIR spectra of PAA/0.25NCT were ascribed to the C–O stretching vibration of the chitin skeleton, indicating the presence of chitin nanofibers in the composite hydrogel (shown in Figure S4).…”

Section: Resultsmentioning

confidence: 99%

“…Similarly, Zheng et al synthesized a PAA/CNF/graphene nanocomposite hydrogel with physical and chemical cross-linking networks, which demonstrated a tensile strength of 320 kPa and a self-healing efficiency of 96.7% within 12 h . Recently, Huang et al also used the dual-network strategy to synthesize a hybrid chitin-poly(ethylene glycol diglycidyl ether)/polyacrylamide (PAAm) hydrogel possessing a fracture stress of 0.499 MPa as soft tissue repairing materials …”

Section: Introductionmentioning

confidence: 99%

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Highly Stretchable, Self-Healable, Freezing-Tolerant, and Transparent Polyacrylic Acid/Nanochitin Composite Hydrogel for Self-Powered Multifunctional Sensors

Jing

Feng

Chen

et al. 2021

ACS Sustainable Chem. Eng.

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To fulfill the current challenges in the hydrogel applications in wearable sensors including low sensitivity, lack of self-healing ability, and nontransparency, we synthesized a polyacrylic acid/nanochitin composite hydrogel with dual cross-linking networks for highly stretchable, transparent, self-healing, and anti-freezing sensors via an eco-friendly method. Dynamic metal-coordination bonds between Al 3+ and carboxyl groups and the hydrogen bonds contributed to the excellent self-healing efficiency of the hydrogel (97%). The dual cross-linking networks provide the composite hydrogel with 400 kPa tensile strength. The hydrogel-based sensors could detect multiple external stimuli, demonstrating a high gauge factor of 2.36 with the strain range of 0−500% and an ultrabroad temperature detection range (−35 to 50 °C). Significantly, the composite hydrogel demonstrates an ultrasensitive thermal response with a sensitivity of 252 %/°C during the cooling process. Moreover, the composite hydrogel was also assembled into a triboelectric nanogenerator to act as a self-powered pressure sensor. Therefore, the developed hydrogel sensors fabricated via a facile and green preparation approach hold great potential for sustainable wearable sensors in electronic skins and personal healthcare.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Highly Stretchable, Self-Healable, Freezing-Tolerant, and Transparent Polyacrylic Acid/Nanochitin Composite Hydrogel for Self-Powered Multifunctional Sensors

Jing

Feng

Chen

et al. 2021

ACS Sustainable Chem. Eng.

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show abstract

“…Chitin and its derivatives (chitosan) are widespread and inexpensive biological materials isolated from the cell walls of fungi (Mucoraceae), insect exoskeletons, and invertebrate skeletons [101]. Chitin was first discovered by Professor Henri Braconnot in 1881 [102].…”

Section: Chitin-based Dressingsmentioning

confidence: 99%

Burn Wound Healing: Clinical Complications, Medical Care, Treatment, and Dressing Types: The Current State of Knowledge for Clinical Practice

Markiewicz-Gospodarek

Kozioł

Tobiasz³

et al. 2022

IJERPH

140

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According to the World Health Organization (WHO), it is estimated that each year approximately 11 million people suffer from burn wounds, 180,000 of whom die because of such injuries. Regardless of the factors causing burns, these are complicated wounds that are difficult to heal and are associated with high mortality rates. Medical care of a burn patient requires a lot of commitment, experience, and multidirectional management, including surgical activities and widely understood pharmacological approaches. This paper aims to comprehensively review the current literature concerning burn wounds, including classification of burns, complications, medical care, and pharmacological treatment. We also overviewed the dressings (with an emphasis on the newest innovations in this field) that are currently used in medical practice to heal wounds.

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“…Many biopolymers with a biodegradable nature can perform as described previously such as PCL, chitin, silk fibroin, and PLA [183][184][185][186][187]. However, the use of chitosan for controlled drug delivery has been of great interest in nanomedicine research [188].…”

Section: Drug Delivery Applications Of Bioengineered Thermo-responsive Scaffolds In Wound Healingmentioning

confidence: 99%

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

Henríquez

Castro-Alpízar

Lopretti-Correa

et al. 2021

IJMS

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Innate and adaptive immune responses lead to wound healing by regulating a complex series of events promoting cellular cross-talk. An inflammatory response is presented with its characteristic clinical symptoms: heat, pain, redness, and swelling. Some smart thermo-responsive polymers like chitosan, polyvinylpyrrolidone, alginate, and poly(ε-caprolactone) can be used to create biocompatible and biodegradable scaffolds. These processed thermo-responsive biomaterials possess 3D architectures similar to human structures, providing physical support for cell growth and tissue regeneration. Furthermore, these structures are used as novel drug delivery systems. Locally heated tumors above the polymer lower the critical solution temperature and can induce its conversion into a hydrophobic form by an entropy-driven process, enhancing drug release. When the thermal stimulus is gone, drug release is reduced due to the swelling of the material. As a result, these systems can contribute to the wound healing process in accelerating tissue healing, avoiding large scar tissue, regulating the inflammatory response, and protecting from bacterial infections. This paper integrates the relevant reported contributions of bioengineered scaffolds composed of smart thermo-responsive polymers for drug delivery applications in wound healing. Therefore, we present a comprehensive review that aims to demonstrate these systems’ capacity to provide spatially and temporally controlled release strategies for one or more drugs used in wound healing. In this sense, the novel manufacturing techniques of 3D printing and electrospinning are explored for the tuning of their physicochemical properties to adjust therapies according to patient convenience and reduce drug toxicity and side effects.

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Chitin-Based Double-Network Hydrogel as Potential Superficial Soft-Tissue-Repairing Materials

Cited by 42 publications

References 92 publications

Highly Stretchable, Self-Healable, Freezing-Tolerant, and Transparent Polyacrylic Acid/Nanochitin Composite Hydrogel for Self-Powered Multifunctional Sensors

Highly Stretchable, Self-Healable, Freezing-Tolerant, and Transparent Polyacrylic Acid/Nanochitin Composite Hydrogel for Self-Powered Multifunctional Sensors

Burn Wound Healing: Clinical Complications, Medical Care, Treatment, and Dressing Types: The Current State of Knowledge for Clinical Practice

Exploration of Bioengineered Scaffolds Composed of Thermo-Responsive Polymers for Drug Delivery in Wound Healing

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