Chirurgia delle ustioni gravi in fase acuta

Baus, A.; Combes, F.; Lakhel, A; Pradier, Jean-Philippe; Brachet, M.; Duhoux, A.; Duhamel, P.; Fossat, S.; Bey, E.

doi:10.1016/s1769-6704(17)86832-7

Cited by 1 publication

(3 citation statements)

References 13 publications

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“…The semipermeable membrane is comparable to human epidermis and controls the loss of water vapor, allows for drainage of exudates, and provides permeability to topical antibiotics. The nylon/silicone membrane provides a flexible adherent covering for the wound surface [2,6,9,10,31,39,41,57,61,67,76,99,107,108]. Biobrane ® holds an FDA 510(k) approval for the treatment of clean partial-thickness burn wounds and donor site wounds.…”

Section: Acellular Dermal Substitutesmentioning

confidence: 99%

“…Nylon present in Biobrane ® is not incorporated, making such an acellular matrix a wound dressing rather than a skin substitute. Hyalomatrix ® [2,6,9,42,107,[109][110][111]] is a bilayer, esterified hyaluronic acid (HYAFF ® ) matrix with an outer silicone membrane. The connective-mimicking layer HYAFF ® is a long-acting derivative of hyaluronic acid providing a microenvironment suitable for optimal tissue repair and accelerated wound healing.…”

Section: Acellular Dermal Substitutesmentioning

confidence: 99%

“…It was shown to be effective in the treatment of the lower limbs. Furthermore, in 401 diabetic ulcers, 70.3% treated with Tissuetech ® healed within less than one year [2,42,107]. OrCel ® is a bi-layered skin substitute formed by human derma fibroblasts entrapped in a bovine collagen sponge, with human keratinocytes on top.…”

Section: Cellularized Dermal Substitutesmentioning

confidence: 99%

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Bioengineered Skin Substitutes: The Role of Extracellular Matrix and Vascularization in the Healing of Deep Wounds

Urciuolo

Casale

Imparato

et al. 2019

JCM

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The formation of severe scars still represents the result of the closure process of extended and deep skin wounds. To address this issue, different bioengineered skin substitutes have been developed but a general consensus regarding their effectiveness has not been achieved yet. It will be shown that bioengineered skin substitutes, although representing a valid alternative to autografting, induce skin cells in repairing the wound rather than guiding a regeneration process. Repaired skin differs from regenerated skin, showing high contracture, loss of sensitivity, impaired pigmentation and absence of cutaneous adnexa (i.e., hair follicles and sweat glands). This leads to significant mobility and aesthetic concerns, making the development of more effective bioengineered skin models a current need. The objective of this review is to determine the limitations of either commercially available or investigational bioengineered skin substitutes and how advanced skin tissue engineering strategies can be improved in order to completely restore skin functions after severe wounds.

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