2019
DOI: 10.1039/c9cc02525a
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Chiroptical sensing of unprotected amino acids, hydroxy acids, amino alcohols, amines and carboxylic acids with metal salts

Abstract: Optical chirality sensing of unprotected amino acids, hydroxy acids, amino alcohols, amines and carboxylic acids based on a practical mix-and-measure protocol with readily available copper, iron, palladium, manganese, cerium or rhodium salts is demonstrated.

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Cited by 21 publications
(15 citation statements)
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“…[18][19][20][21][22] This phenomenon has been recently exploited in a novel chiroptical ee sensing technique which is based on the detection of induced visible ECD bands by complexation of transition metal ions with chiral organic analytes. 24,25 In addition to transition metal ions, it has also been shown that alkali (Li + , Na + , K + ) and alkaline earth metal ions (Mg 2+ , Ca 2+ , Sr 2+ , Ba 2+ ) [26][27][28][29][30][31][32][33] have a tendency to form complexes with hydroxycarboxylates. Their presence in solutions of HCAs was shown to induce changes in the intensity and Abstract: Electronic circular dichroism (ECD) and anisotropy spectra carry information on differential absorption of leftand right-circularly polarised light (LCPL and RCPL) by optically active compounds.…”
Section: Introductionmentioning
confidence: 99%
“…[18][19][20][21][22] This phenomenon has been recently exploited in a novel chiroptical ee sensing technique which is based on the detection of induced visible ECD bands by complexation of transition metal ions with chiral organic analytes. 24,25 In addition to transition metal ions, it has also been shown that alkali (Li + , Na + , K + ) and alkaline earth metal ions (Mg 2+ , Ca 2+ , Sr 2+ , Ba 2+ ) [26][27][28][29][30][31][32][33] have a tendency to form complexes with hydroxycarboxylates. Their presence in solutions of HCAs was shown to induce changes in the intensity and Abstract: Electronic circular dichroism (ECD) and anisotropy spectra carry information on differential absorption of leftand right-circularly polarised light (LCPL and RCPL) by optically active compounds.…”
Section: Introductionmentioning
confidence: 99%
“…In accordance with our chiral amine sensing study, these additional 21 substrates were selected to encompass structures exhibiting asmall aromatic ring as well as some that are devoid of ac hromophore and therefore increasingly challenging.N evertheless,d istinct CD effects were obtained without exception just by fast mixing of the assay components and CD analysis without further delay (see SI). [19,[38][39][40][41][42][43] Scheme 1. Chiroptical redox switching using NaBH 4 and air as external stimuli.…”
Section: Methodsmentioning
confidence: 99%
“…Therefore, recognizing chiral enantiomers is of great significance for drug design and understanding the metabolism and regulation in organisms. At present, the identification and resolution of chiral molecules are usually achieved by means of high-performance liquid chromatography [ 3 ], capillary electrophoresis [ 4 ], electrochemistry [ 5 ], and circular dichroism [ 6 ], which are often time-consuming, require cost-ineffective equipment, produce low responses, and present difficulty achieving real-time online analysis. Consequently, the development of a new type of enantiomer recognition platform is key to meeting the needs of label-free, highly sensitive, fast-response detection.…”
Section: Introductionmentioning
confidence: 99%