Chiroplasmonic assemblies of gold nanoparticles as a novel method for sensitive detection of alpha-fetoprotein

Zhao, Hongyu; Bian, Shuhui; Yang, Yue; Wu, Xuping

doi:10.1007/s00604-017-2207-2

Cited by 25 publications

(21 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Figure b displays the detection of alpha‐fetoprotein (AFP) that is the most abundant plasma protein in the human fetus using aptamer conjugated Au nanoparticles. Through the specific interaction of the aptamer with AFP to form dimers, CD signals at 528 nm are enhanced . Elevated serum AFP levels have been found associated with some tumors such as hepatocellular carcinoma.…”

Section: Sensing Applicationsmentioning

confidence: 99%

Section: Sensing Applicationsmentioning

confidence: 99%

“…Cube-like Au nanoparticles with different edges and chiral nanoparticles with helicoid morphologies. [26] Ligand exchange after synthesis Assembling nanoparticles into chiral strucutres Au-Ag heterodimer, [32] Au nanoparticle dimer, [45] Au nanorod dimer, [40c] Au double helice, [29] Au linear chain, [30] Ag nanoparticle chain, [37] side-by-side assemblies of Au nanorods, [31] polymers composed of Ag core-Au shell nanoparticles and Au nanoparticles. [50] for the preparation of chiral and achiral Au nanomaterials, respectively.…”

Section: Examples Of Chiral Nanomaterialsmentioning

confidence: 99%

“…Through the specific interaction of the aptamer with AFP to form dimers, CD signals at 528 nm are enhanced. [45] Elevated serum AFP levels have been found associated with some tumors such as hepatocellular carcinoma. The assay provides linearity for the detection of AFP in the concentration range of 0.02-5 ng mL -1 , showing its potential for cancer diagnosis.…”

Section: Cd-based Sensing Systemsmentioning

confidence: 99%

“…Reproduced with permission. [45] Copyright 2017, Springer Nature. c) Strategy for forming Au heterodimers through PCR and for enhancing their CD signal by deposition of Au or Ag atoms on their surfaces.…”

Section: Cd-based Sensing Systemsmentioning

confidence: 99%

See 4 more Smart Citations

Chiral Ag and Au Nanomaterials Based Optical Approaches for Analytical Applications

Xü

Lin

2019

Part & Part Syst Charact

View full text Add to dashboard Cite

Sensing of chiral compounds has gained great attentions for many decades. Chiral nanomaterials with a greater surface area, optical properties, and stability have however not been well realized in this field. Herein, strategies for the preparation of chiral Ag and Au nanomaterials are focused upon, including Ag and Au nanoparticles conjugated with chiral molecules with/without containing fluorophores, chiral nanoassemblies of Ag and Au nanoparticles, and chiral Ag and Au nanoclusters. The chirality of nanomaterials originates from their core and/or ligand, meanwhile that for nanoassemblies results from their complex spatial configuration. An emphasis is given to circular dichroism, colorimetry/UV–vis absorption, and fluorescence detection modes for sensing enantiomers and achiral analytes using the chiral Ag and Au nanomaterials. Several interesting examples for quantitation of DNA, proteins, peptides, drugs, and pollutants are provided to highlight their potential as sensitive and selective nanomaterials for enantiomer recognition and sensing of achiral analytes. Several important issues to be solved when using chiral nanomaterials for chiral recognition are specified. Some strategies for improving the sensitivity and selectivity of chiral nanomaterials for chiral recognition are suggested. The aim is to bring more attention to the potential of chiral nanomaterials for sensing important analytes such as chiral drugs.

show abstract

Section: Sensing Applicationsmentioning

confidence: 99%

Section: Sensing Applicationsmentioning

confidence: 99%

Section: Examples Of Chiral Nanomaterialsmentioning

confidence: 99%

Section: Cd-based Sensing Systemsmentioning

confidence: 99%

Section: Cd-based Sensing Systemsmentioning

confidence: 99%

See 3 more Smart Citations

Chiral Ag and Au Nanomaterials Based Optical Approaches for Analytical Applications

Xü

Lin

2019

Part & Part Syst Charact

View full text Add to dashboard Cite

show abstract

Chiral Nanostructures for Biorecognition and Bioanalysis

Xu¹,

Zhao²,

Wu³

2022

Chiral Nanoprobes for Biological Applications

View full text Add to dashboard Cite

Advanced Functional Structure‐Based Sensing and Imaging Strategies for Cancer Detection: Possibilities, Opportunities, Challenges, and Prospects

Kumar

Kukkar

Hashemi

et al. 2019

Adv Funct Materials

View full text Add to dashboard Cite

Cancer is the second most common cause of death in the world. The principal limitations thus far encountered in the clinical practice of probing cancer are diverse and include low sensitivity, time consumption, bulkiness, and cost. In this respect, nanomaterial (NM)-based sensing techniques are recognized as a superior alternative to efficiently resolve such limitations. A better understanding of NM-based sensing platforms is thus important so that these novel avenues can easily be explored for clinical applications. These platforms have the merits of high sensitivity, high specificity, rapid response, and easy-to-read signals. This review offers a comprehensive survey of NM-based advanced cancer-sensing techniques and will help the scientific community establish optimum sensing strategies based on an accurate assessment of the interactions between cancer biomarkers and NM-based platforms.but are not limited to, carcinoma, sarcoma, leukemia, lymphoma, non-Hodgkin lymphoma, myeloma, central nervous system cancer, lung and bronchus cancer, colon cancer, rectum cancer, prostate cancer, bladder cancer, kidney and renal pelvis cancer, endometrial cancer, pancreatic cancer, liver cancer, and thyroid cancers. [1] Moreover, the most commonly occurring cancers tend to differ by common criteria like sex and age. For example, men are at risk for prostate, lung, and colorectal cancer, women are at risk for breast, lung and colorectal cancer, and children are at risk for leukemia, brain tumors, and lymphoma. The severity of the cancer depends upon the development level or staging of the disease. [2] Likewise, the type of treatment required to treat the cancer is determined by the staging of the disease.The more severe condition of cancer is metastasis, i.e., the uncontrolled growth of cells that invade surrounding tissues. The metastasis condition of cancer can affect any organ of the body. [3] As per the WHO 2010 report on cancer, the lives of 30% patients could have been saved if the cancer was diagnosed earlier. The detection of cancer is not easy because the immune system does not necessarily consider cancerous cells as foreign bodies. However, a few changes (such as altered biomarker levels and the presence of cancerous cells in biological fluids) can be detected. [4] In general, cancer biomarkers are overexpressed proteins present in blood/serum and at the cancer cell surface. The accurate and efficient detection of these biomarkers can be useful for cancer detection. The major problem with biomarkers is their low level in the body during the earlier stages of cancer. Hence, an efficient sensor/device capable of detecting these molecules even at very low levels, if developed, could help the clinician efficiently diagnose cancer cells in the human body.The sensing techniques presently used by clinicians suffer from several limitations; specifically, they are time consuming, bulky, have low sensitivity, and are expensive. Nanomaterial (NM)-based techniques have become an important alternative to the laborious conventional...

show abstract

Chiroplasmonic assemblies of gold nanoparticles as a novel method for sensitive detection of alpha-fetoprotein

Cited by 25 publications

References 31 publications

Chiral Ag and Au Nanomaterials Based Optical Approaches for Analytical Applications

Chiral Ag and Au Nanomaterials Based Optical Approaches for Analytical Applications

Chiral Nanostructures for Biorecognition and Bioanalysis

Advanced Functional Structure‐Based Sensing and Imaging Strategies for Cancer Detection: Possibilities, Opportunities, Challenges, and Prospects

Contact Info

Product

Resources

About