Chirality influence on the cytotoxic properties of anionic chiral bis(N-heterocyclic carbene)silver complexes

Carrasco, Carlos J.; Montilla, Francisco; Álvarez, Eleuterio; Calderón-Montaño, José Manuel; López‐Lázaro, Miguel; Galindo, Agustı́n

doi:10.1016/j.jinorgbio.2022.111924

Cited by 6 publications

(2 citation statements)

References 58 publications

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“…Firstly, to evaluate the possible cytotoxic effects of the compounds on HaCaT cells, they were seeded into 96-well plates (1.5 × 10 4 cells/well) and incubated for 24 h at 37 • C and 5% CO 2 . Then, the keratinocytes were treated with different concentrations of the compounds (0.625, 1.25, 2.5, 5, and 10 µM) and incubated for another 24 h. To determine the photoprotective effect of the compounds, the cells were preincubated with the compounds at the same concentrations for 4 h. Subsequently, keratinocytes were washed with PBS and exposed to the selected UVB dose (50 mJ/cm 2 ) for 30 s. PBS was replaced with fresh culture medium and incubated for 24 h. For the two experimental approaches, the medium was replaced and 200 µL of resazurin (20 µg/mL) were added for 3-4 h. The absorbance was measured at 540 and 620 nm using a spectrophotometer reader (iMark TM microplate reader, BIO-RAD, Hercules, CA, USA) [20].…”

Section: Assessment Of Cell Viability By Resazurin Assay In Hacat Ker...mentioning

confidence: 99%

Photoprotective Effects of Two New Morin-Schiff Base Derivatives on UVB-Irradiated HaCaT Cells

García-Gil,

Rodríguez-Luna,

Ávila-Román

et al. 2024

Antioxidants

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Ultraviolet (UV) radiation harms the skin, causing oxidative damage, inflammation, and disruption of the skin’s barrier function. There is considerable interest in identifying new natural ingredients with antioxidant and anti-inflammatory properties to serve as adjuvants in sunscreens. The flavonoid morin (1) can undergo structural modifications to enhance its biological properties. The aim of this study was to synthesize two new morin-Schiff base derivatives, morin oxime (2) and morin semicarbazone (3), comparing their photoprotective effects with that of the parent compound on UVB-exposed HaCaT keratinocytes. The chemical structure of the novel compounds was revealed based on spectroscopic data analysis. Our findings demonstrated that derivatives 2 and 3 enhanced the light absorption capability in the UV–visible (vis) range compared to 1. Tested compounds exhibited a higher scavenger capacity than Trolox. Moreover, pre-treatment with all compounds protected HaCaT cells from UVB-induced cell death. Compound 3 demonstrated the strongest antioxidant effect, reducing reactive oxygen species (ROS) generation and, subsequently, malondialdehyde (MDA) levels. Additionally, compounds 2 and 3 exhibited greater anti-inflammatory effects than compound 1, significantly reducing interleukin (IL)-6 production levels at all tested concentrations. These findings have demonstrated, for the first time, a promising photoprotective activity of two new Schiff base derivatives and suggest their use as natural sunscreen ingredients.

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Section: Assessment Of Cell Viability By Resazurin Assay In Hacat Ker...mentioning

confidence: 99%

Photoprotective Effects of Two New Morin-Schiff Base Derivatives on UVB-Irradiated HaCaT Cells

García-Gil,

Rodríguez-Luna,

Ávila-Román

et al. 2024

Antioxidants

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“…Second, an interesting chirality–anticancer relationship was detected when comparing the activity of an enantiomerically related compound. Compound II26-a showed a better cytotoxic activity than its enantiomeric derivative II26-b [ 117 ].…”

Section: Imidazole-based Supermolecules As Medicinal Agentsmentioning

confidence: 99%

Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes

Tan

Zhang

et al. 2023

Pharmaceutics

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The electron-rich five-membered aromatic aza-heterocyclic imidazole, which contains two nitrogen atoms, is an important functional fragment widely present in a large number of biomolecules and medicinal drugs; its unique structure is beneficial to easily bind with various inorganic or organic ions and molecules through noncovalent interactions to form a variety of supramolecular complexes with broad medicinal potential, which is being paid an increasing amount of attention regarding more and more contributions to imidazole-based supramolecular complexes for possible medicinal application. This work gives systematical and comprehensive insights into medicinal research on imidazole-based supramolecular complexes, including anticancer, antibacterial, antifungal, antiparasitic, antidiabetic, antihypertensive, and anti-inflammatory aspects as well as ion receptors, imaging agents, and pathologic probes. The new trend of the foreseeable research in the near future toward imidazole-based supramolecular medicinal chemistry is also prospected. It is hoped that this work provides beneficial help for the rational design of imidazole-based drug molecules and supramolecular medicinal agents and more effective diagnostic agents and pathological probes.

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Metal N-heterocyclic carbene complexes as potential metallodrugs in antitumor therapy

Zhang,

Yin,

Zhang

et al. 2024

Coordination Chemistry Reviews

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Chirality influence on the cytotoxic properties of anionic chiral bis(N-heterocyclic carbene)silver complexes

Cited by 6 publications

References 58 publications

Photoprotective Effects of Two New Morin-Schiff Base Derivatives on UVB-Irradiated HaCaT Cells

Photoprotective Effects of Two New Morin-Schiff Base Derivatives on UVB-Irradiated HaCaT Cells

Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes

Metal N-heterocyclic carbene complexes as potential metallodrugs in antitumor therapy

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