Chirality-Enabled Liquid Crystalline Physical Gels with High Modulus but Low Driving Voltage

Ruan, Huan; Chen, Guannan; Zhao, Xiaoyu; Wang, Yong; Liao, Yonggui; Peng, Haiyan; Feng, Chuanqi; Xie, Xiaolin; Smalyukh, Ivan I.

doi:10.1021/acsami.8b14488

Cited by 13 publications

(14 citation statements)

References 69 publications

(126 reference statements)

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“…The stiffness recorded for the LPF-AD and LPF-CMDH gels were 3.07 and 10.54, respectively (Table ). These results generally agree with previously reported studies on the effect that the mechanical properties of substrates have on cell adhesion, cell viability, and the spreading morphology of cells. ,,− The hybrid hydrogels used in the preparation of these substrates thus present unique advantages compared to previous substrates reported. First of all, the hydrogels are supramolecular in nature implying they have the advantage of facile preparation (described in the Experimental Section) and does not involve complex experimental routes.…”

Section: Resultssupporting

confidence: 91%

Mechanically Stable C2-Phenylalanine Hybrid Hydrogels for Manipulating Cell Adhesion

Dang-i

Kousar

Liu

et al. 2019

ACS Appl. Mater. Interfaces

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Tuning of the viscoelastic properties of supramolecular hydrogels to be used as biological material substrates in tissue engineering has become significantly relevant in recent years due to their ability to influence cell fate. In the quest to enhance the stability and mechanical properties of a derived C2-phenylalanine gelator (LPF), derivatives of the polysaccharide dextran were incorporated as additives to promote hydrogen bonding and π−π stacking with the gelator. Dextran was esterified to yield carboxymethyl dextran (CMDH), which was subsequently amidated to furnish amino dextran (AD), the resulting hybrid hydrogels were denoted as LPF-AD x and LPF-CMDH x , where x represents the amount of AD and CMDH (mg). The LPF gelator interacted with the carboxyl and amino functional groups of the CMDH and AD, respectively, through hydrogen bonding and π−π stacking, resulting in mechanically stable hydrogels. Morphological studies revealed that the hybrid hydrogels were formed as a result of dense highly branched thin and broad fibers for LPF-AD and LPF-CMDH, respectively. Rheological studies confirmed the superiority of the hybrid hydrogels over the neat hydrogel, where LPF-CMDH 3 exhibited the best mechanical properties with an improved elastic modulus of 11 654 Pa over 1518 and 140 Pa for LPF-AD 4.5 and LPF, respectively. The adhesion and spreading behavior of NIH 3T3 fibroblast cells were significantly improved on the LPF-CMDH 3 substrate owing to their enhanced mechanical properties. The tuning of the mechanical properties of the therein hydrogels via the facile incorporation of biodegradable and biocompatible functionalized additives opens up avenues for strengthening the supposed weak supramolecular gelators and hence increasing their potential of being employed largely in the field of tissue engineering.

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Section: Resultssupporting

confidence: 91%

Mechanically Stable C2-Phenylalanine Hybrid Hydrogels for Manipulating Cell Adhesion

Dang-i

Kousar

Liu

et al. 2019

ACS Appl. Mater. Interfaces

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“…Materials with circularly polarized luminescence (CPL) property have multiple promising applications in the field of optoelectronic devices, and high potential for electronic and photonic devices. − To fabricate synthetic CPL materials, an important approach was chiral amplification, following a “sergeant and soldier” rule. , A small amount of chiral dopants (the sergeant) are mixed with a large amount of achiral molecules (the soldier) to guide the latter to assume a helical twist. Chirality was then transferred and amplified to the whole molecular system with significantly enhanced CPL.…”

mentioning

confidence: 99%

“…1−13 To fabricate synthetic CPL materials, an important approach was chiral amplification, following a "sergeant and soldier" rule. 14,15 A small amount of chiral dopants (the sergeant) are mixed with a large amount of achiral molecules (the soldier) to guide the latter to assume a helical twist. Chirality was then transferred and amplified to the whole molecular system with significantly enhanced CPL.…”

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confidence: 99%

Direct Visualization of Chiral Amplification of Chiral Aggregation Induced Emission Molecules in Nematic Liquid Crystals

Xia

Xie

et al. 2021

ACS Nano

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Chiral amplification in liquid crystals (LCs) is a well-known strategy. However, current knowledge about the underlying mechanism was still lacking; in particular, how it was realized at the nano scale still remained to be revealed. Here, we provide systematical exploration of chiral amplification of chiral aggregation induced emission (AIE) molecules in LCs from direct visualization of their co-assemblies at the nano scale to theoretical calculation of the molecular packing modes on a single molecular level. Using AFM imaging,we directly visualized the co-assembly formed by chiral AIE molecules/LCs at the nano scale: the chiral AIE molecules self-assembled into helical fibers to serve as the helical template for LCs to bind, while the LCs helically bound to the helical fibers to form the co-assembly, giving the morphology of pearled necklaces or thick rods. Theoretical calculation suggested that chiral AIE molecules were packed into left-handed helical fibers with a large volume of empty space between neighboring molecules, which provided the binding cites for LCs. Structural analysis showed that the π–π stacking between aromatic groups from LCs and TPE groups and the σ–π hyperconjugation between LC aromatic groups and cholesterol aliphatic groups play an important role in stabilizing the binding of LCs in the confined space on the surface of the helical assemblies.

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“…Morphological evolution was observed, with the appearance of helical structures induced by coassembly . Supramolecular chirality was reversed based on the chiroptical inversion in circular dichroism (CD) and circularly polarized luminescence (CPL) spectrometry, which evidenced that the point chirality in amino acids was successfully transferred to the supramolecular scale through assembly and aggregation, which was altered by coassembly. , Modification with different amino acids and coassembly with Mm can regulate the inversion, amplification, and transfer of chiral signals. , Crystalline powder X-ray diffraction (XRD) confirmed the change of the molecular stacked structure. The photoisomerization property of stilbene endowed it with photoresponsiveness.…”

Section: Introductionmentioning

confidence: 86%

“…27 evidenced that the point chirality in amino acids was successfully transferred to the supramolecular scale through assembly and aggregation, which was altered by coassembly. 28,29 Modification with different amino acids and coassembly with Mm can regulate the inversion, amplification, and transfer of chiral signals. 30,31 Crystalline powder X-ray diffraction (XRD) confirmed the change of the molecular stacked structure.…”

Section: ■ Introductionmentioning

confidence: 99%

Photoresponsive Supramolecular Chiral Composites Based on Hydrogen-Bonded Coassembly

et al. 2021

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Dynamic control of supramolecular chirality and chiroptical properties is a challenging task and has great significance in the preparation of responsive and intelligent functional materials. Here, we report the dynamic evolution of supramolecular chirality and the corresponding chiroptical properties via multicomponent coassembly driven by intermolecular hydrogen bonds. Stilbene conjugated with amino acids can self-assemble into chiral nanostructures with chiroptical activities including circular dichroism and circularly polarized luminescence (CPL). After coassembly with melamine (Mm), a macroscopic nanohelix was observed in assemblies. This evolution process is accompanied by variations in Cotton effects and CPL properties depending on the amino acid domains. The photoresponsiveness of the isomerization reaction was successfully achieved due to the existence of the stilbene structure, where the fluorescence changes can be applied to fluorescent carving. This work illustrates the dynamic chirality evolution and response, providing a simple method for the design and manufacture of smart chiroptical materials.

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Chirality-Enabled Liquid Crystalline Physical Gels with High Modulus but Low Driving Voltage

Cited by 13 publications

References 69 publications

Mechanically Stable C2-Phenylalanine Hybrid Hydrogels for Manipulating Cell Adhesion

Mechanically Stable C2-Phenylalanine Hybrid Hydrogels for Manipulating Cell Adhesion

Direct Visualization of Chiral Amplification of Chiral Aggregation Induced Emission Molecules in Nematic Liquid Crystals

Photoresponsive Supramolecular Chiral Composites Based on Hydrogen-Bonded Coassembly

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