Chirality‐Driven Transportation and Oxidation Prevention by Chiral Selenium Nanoparticles

Abstract

The chirality of nanoparticles directly influences their transport and biological effects under physiological conditions, but the details of this phenomenon have rarely been explored. Herein, chiral GSH‐anchored selenium nanoparticles (G@SeNPs) are fabricated to investigate the effect of their chirality on their transport and antioxidant activity. G@SeNPs modified with different enantiomers show opposite handedness with a tunable circular dichroism signal. Noninvasive positron emission tomography imaging clearly reveals that 64Cu‐labeled l‐G@SeNPs experience distinctly different transport among the major organs from that of their d‐and dl‐counterparts, demonstrating that the chirality of the G@SeNPs influences the biodistribution and kinetics. Taking advantage of the strong homologous cell adhesion and uptake, l‐G@SeNPs have been shown here to effectively prevent oxidation damage caused by palmitic acid in insulinoma cells.

Triangle-Shaped Tellurium Nanostars Potentiate Radiotherapy by Boosting Checkpoint Blockade Immunotherapy

“…This SeNPs exhibited higher average size (about 170 nm) than that of L-G@SeNPs (about 126.7 nm) reported in the previous studies. 40 Secondly, Pd icosahedra were obtained according to previous literature by using polyvinylpyrrolidone (PVP) as a stabilizer and citric acid as a reductant. 41 In contrast, the use of GSH and Fru as reducing agent produced aggregated nanoparticles with average sizes of 29.4 nm.…”

Oral Insulin Delivery Platforms: Strategies To Address the Biological Barriers

“…In addition, the chirality of NPs should also be taken into consideration, as it affects the transport in the biological environment. [47] 2) More efforts should be focused on improving the vital pharmacokinetic properties of insulin formulations.E fficient, long-acting oral insulin capable of maintaining normal BGLs would clearly be of great interest. For example,c reating oral insulin that could function as an artificial liver or pancreas and be released as needed has received much attention.…”

Plattformen für die orale Insulinabgabe: Strategien zur Beseitigung der biologischen Barrieren

“…Materialien, die mit der GI‐Mikroumgebung reagieren und Phasenübergänge durchlaufen, sind ebenfalls eine Untersuchung wert. Darüber hinaus sollte auch die Chiralität von NPs berücksichtigt werden, die den Transport unter biologischen Bedingungen beeinflusst [47] Weitere Forschungen sollten auf die Verbesserung der lebenswichtigen pharmakokinetischen Eigenschaften von Insulinformulierungen gerichtet werden.…”

“…Materialien, die mit der GI‐Mikroumgebung reagieren und Phasenübergänge durchlaufen, sind ebenfalls eine Untersuchung wert. Darüber hinaus sollte auch die Chiralität von NPs berücksichtigt werden, die den Transport unter biologischen Bedingungen beeinflusst [47] …”