Chirality-directed self-assembling of long-chain dialkyl 3,7-diazabicyclo[3.3.1]nonane-2,6-dione-1,5-dicarboxylates

Methyl nitroacetate and 3-nitropropionate in the synthesis of hexahydropyrimidines and piperidines

“…In the case of methyl nitroacetate both the 5-nitrohexahydropyrimidine and isomeric 3,5-di(methoxycarbonyl)-1-methyl-3,5-dinitropiperidines are formed.The reaction of primary amines and formaldehyde with compounds containing a mobile hydrogen atom on a carbon atom is widely used in organic synthesis as a convenient method for preparing tetrahydro-1,3-oxazines, hexahydropyrimidines [1, 2], and also 3-aza-[3-6] and 3,7-diazabicyclo[3,3,1]nonanes [3,[7][8][9][10][11][12][13][14][15]. Members of this class of compounds show high physiological activity and are used in medical practice as antimicrobial, antiviral, antitumor and other medicinal agents [10][11][12]16].…”

Stereoregular self-assembling of diastereomeric bicyclic bis-lactam diesters

“…The geometry of central bicyclic fragments of two independent molecules is practically identical to that of previously studied diethyl and didodecyl derivatives. 1,2 The angle between C(1)-C(7)-C(10) and CO 2 planes varies in the range 59.5-68.5°.…”

“…In spite of the presence of chiral groups, two independent molecules are arranged pseudocentrosymmetrically (Figure 2) † (S)-(+)-1-Bromo-2-methylbutane: bp 55 °C (80 torr), [a] D 20 4.5° (c 5.0, CHCl 3 ). 1 2 J AB -10.8 Hz, 3 J AX 6.4 Hz, 3 J BX 6.0 Hz; diastereomer b: ABX, ∆n 12.0 Hz, 2 J AB -10.8 Hz, 3 J AX 6.4 Hz, 3 J BX 6.0 Hz), 6.67 (br. d, 2H, 3,7-NH, 3 J 4.0 Hz).…”

“…Similar results were obtained using other solvent systems. 2 J AB -10.5 Hz, 3 J AX 6.8 Hz, 3 J BX 6.0 Hz, diastereomer b), 6.96 (br. s, 2H, HN).…”