Abstract:Introduction: Chirality is a crucial mechanical cue within the extracellular matrix during tissue repair and regeneration. Despite its key roles in cell behavior and regeneration efficacy, our understanding of chirality-biased protein profile in vivo remains unclear.Methods: In this study, we characterized the proteomic profile of proteins extracted from bone defect areas implanted with left-handed and right-handed scaffold matrices during the early healing stage. We identified differentially-expressed protein… Show more
“…Furthermore, Zeng et al implanted chiral matrices in rat cranial bone defects. 282 The proteomic analysis at days 3 and 7 post-implantation uncovered that left-handed chirality enhanced the expression of cell adhesion and GTPase-related proteins. This activation of Rho GTPase and Akt1 in the left-handed chiral scaffolds had positive influences on bone regeneration by modulating M2 macrophage polarization and tissue repair.…”
Section: Chiral Nanomaterials In Tissue Engineeringmentioning
“…Furthermore, Zeng et al implanted chiral matrices in rat cranial bone defects. 282 The proteomic analysis at days 3 and 7 post-implantation uncovered that left-handed chirality enhanced the expression of cell adhesion and GTPase-related proteins. This activation of Rho GTPase and Akt1 in the left-handed chiral scaffolds had positive influences on bone regeneration by modulating M2 macrophage polarization and tissue repair.…”
Section: Chiral Nanomaterials In Tissue Engineeringmentioning
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