Chirality Bias Tissue Homeostasis by Manipulating Immunological Response

Jiang, Shengjie; Zeng, Qiang; Zhao, Kai; Liu, Jinying; Sun, Qiannan; Huang, Kang; He, Yayi; Zhang, Xuehui; Wang, Hui; Shi, Xinghua; Feng, Chuanliang; Deng, Xuliang; Wei, Yan

doi:10.1002/adma.202105136

Cited by 23 publications

(20 citation statements)

References 66 publications

(24 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Supramolecular chirality arises from asymmetric spatial stacking of chiral or achiral molecules, which can be found in many supramolecular systems. − Dynamic inversion of supramolecular chirality usually offers an effective strategy to regulate chiral structure-related functions (e.g., enantioselective separation, , chiral recognition or sensing, , asymmetric catalysis, , chiral optoelectronics, , and biomedicine − ). Despite the fact that the dynamic inversion of supramolecular chirality has been achieved via co-assembling with other molecules, − coordinating with metal ions, − varying assembling temperature, , light irradiation, , and regulation of solvent polarity, − it has remained a challenge to realize helicity inversion via in situ modulation of building molecules due to the subtle balance between intermolecular attraction and repulsion easily disturbed by altering the molecular structure of building units.…”

Section: Introductionmentioning

confidence: 99%

Inversion of Supramolecular Chirality by In Situ Hydrolyzation of Achiral Diethylene Glycol Motifs

Wang

Gao

et al. 2022

J. Phys. Chem. B

Self Cite

View full text Add to dashboard Cite

Chiral inversion of supramolecular assemblies is of great research interest due to its broad practical applications. However, chiral structure transition induced by in situ regulation of building molecules has remained a challenge. Herein, left-handed fibrous assemblies were constructed by C 2-symmetic l -phenylalanine coupled with diethylene glycol (LPFEG) molecules. In situ hydrolyzing terminal diethylene glycol motifs in LPFEG successfully inverted the chirality of the nanofibers from left- to right-handedness. The transition of right-handed fibers into left-handed fibers could also be achieved via hydrolyzing DPFEG molecules. Circular dichroism (CD) spectroscopy, 1D and 2D nuclear magnetic resonance (NMR) spectroscopy, and Fourier transform infrared (FT-IR) spectroscopy revealed that the back-folded achiral diethylene glycol played a vital role in L/DPFEG molecular arrangements and removing terminal diethylene glycol could induce the opposite rotation of molecular assemblies. Thanks to this merit, the enantioselective separation of racemic phenylalanine was obtained and the enantiomeric excess (ee) values could achieve around ±20% after separation. This study not only provides a new strategy to regulate the chiral structure via dynamic modulation of terminal substituents but also presents a promising application in the field of enantioselective separation.

show abstract

Section: Introductionmentioning

confidence: 99%

Inversion of Supramolecular Chirality by In Situ Hydrolyzation of Achiral Diethylene Glycol Motifs

Wang

Gao

et al. 2022

J. Phys. Chem. B

Self Cite

View full text Add to dashboard Cite

show abstract

“…The production of interleukine (IL) −6 and regulated on activation, normal T cell expressed and secreted (RANTES) in macrophages was better produced by the L-chirality connection of amantadine containing peptidoglycan fragments ( Manček-Keber et al, 2020 ). Jiang et al (2022) reported that pathology-mimetic M-nanofibers promoted macrophage M2 phenotypic polarization more than physiology-mimetic simulated P-nanofibers, significantly inhibited inflammation and promoted tissue regeneration.…”

Section: Biomaterials Design and Macrophage Regulationmentioning

confidence: 99%

Biomaterial scaffolds regulate macrophage activity to accelerate bone regeneration

Liu

Zhu²,

Li³

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Bones are important for maintaining motor function and providing support for internal organs. Bone diseases can impose a heavy burden on individuals and society. Although bone has a certain ability to repair itself, it is often difficult to repair itself alone when faced with critical-sized defects, such as severe trauma, surgery, or tumors. There is still a heavy reliance on metal implants and autologous or allogeneic bone grafts for bone defects that are difficult to self-heal. However, these grafts still have problems that are difficult to circumvent, such as metal implants that may require secondary surgical removal, lack of bone graft donors, and immune rejection. The rapid advance in tissue engineering and a better comprehension of the physiological mechanisms of bone regeneration have led to a new focus on promoting endogenous bone self-regeneration through the use of biomaterials as the medium. Although bone regeneration involves a variety of cells and signaling factors, and these complex signaling pathways and mechanisms of interaction have not been fully understood, macrophages undoubtedly play an essential role in bone regeneration. This review summarizes the design strategies that need to be considered for biomaterials to regulate macrophage function in bone regeneration. Subsequently, this review provides an overview of therapeutic strategies for biomaterials to intervene in all stages of bone regeneration by regulating macrophages.

show abstract

“…By constructing chiral poly-PPFU-g-PLL and poly-PPFU-g-PDL on the surface of the material, Duan et al 27 up-regulated the expression of CD44 and integrin on the membrane of macrophages, affected cell adhesion and the cytoskeletal state, and finally induced macrophage M2 polarization. Jiang et al 28 regulated integrin expression by constructing lefthanded chiral fibers mimicking pathology and right-handed chiral fibers mimicking physiology, mediated cytoskeletal contractility, activated the mechanosensitive ion channel PIEZO1 for Ca 2+ influx, and prompted cellular M2 polarized immune response.…”

Section: Introductionmentioning

confidence: 99%

Regulation of Macrophage Polarization on Chiral Potential Distribution of CFO/P(VDF-TrFE) Films

Zhou

Zhang

et al. 2023

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Surface potentials of biomaterials have been shown to regulate cell fate commitment. However, the effects of chirality-patterned potential distribution on macrophage polarization are still only beginning to be explored. In this work, we demonstrated that the chirality-patterned potential distribution of CoFe2O4/poly(vinylidene fluoride-trifluoroethylene) (CFO/P(VDF-TrFE)) films could significantly down-regulate the M1 polarization of bone marrow-derived macrophages (BMDMs). Specifically, the dextral-patterned surface potential distribution simultaneously up-regulated the expression of M2-related markers of BMDMs. The results were attributed to the sensitive difference of integrin subunits (α5β1 and αvβ3) to the dextral- and sinistral-patterned surface potential distribution, respectively. The interaction difference between the integrin subunits and surface potential distribution altered the cell adhesion and cytoskeletal structure and thereby the polarization behavior of BMDMs. This work, therefore, emphasizes the importance of chirality of potential distribution on cell behavior and provides a new strategy to regulate the immune response of biomaterials.

show abstract

Chirality Bias Tissue Homeostasis by Manipulating Immunological Response

Cited by 23 publications

References 66 publications

Inversion of Supramolecular Chirality by In Situ Hydrolyzation of Achiral Diethylene Glycol Motifs

Inversion of Supramolecular Chirality by In Situ Hydrolyzation of Achiral Diethylene Glycol Motifs

Biomaterial scaffolds regulate macrophage activity to accelerate bone regeneration

Regulation of Macrophage Polarization on Chiral Potential Distribution of CFO/P(VDF-TrFE) Films

Contact Info

Product

Resources

About