Chiral π–Cu(ii)-catalyzed site-, exo/endo-, and enantioselective dearomative (3 + 2) cycloadditions of isoquinolinium ylides with enamides, dienamides, and a trienamide

Abstract

We report a dearomative (3 + 2) cycloaddition between isoquinolinium ylides and enamides, dienamides, or a trienamide, which is catalyzed by a chiral π–Cu(ii) complex and proceeds in a site-selective, exo/endo-selective, and enantioselective manner.