Chiral Ytterbium Complex‐Catalyzed Direct Asymmetric Aldol—Tishchenko Reaction: Synthesis of anti‐1,3‐Diols.

Abstract

Alcohols Q 0230 Chiral Ytterbium Complex-Catalyzed Direct Asymmetric Aldol-Tishchenko Reaction: Synthesis of anti-1,3-Diols. -The asymmetric aldol-Tishchenko reaction of aromatic aldehydes with aliphatic and aromatic ketones is efficiently catalyzed by a new chiral Yb-amino alcohol complex. The reaction proceeds with generation of three new stereocenters in good yields and enantioselectivities. The reaction mechanism is discussed in detail. -(MLYNARSKI*, J.; RAKIEL, B.; STODULSKI, M.; SUSZCZYNSKA, A.; FRELEK, J.; Chem. Eur.

Chirality sensing of bioactive compounds with amino alcohol unit via circular dichroism

“…70,71 However, until now no reports in the literature described the utilization of the in situ methodology for 1,3-amino alcohols. If so, whether the correlation between CEs signs and 3D structure is the same as for vic-amino alcohols.…”

“…So far, in the literature, there are known reports of successful use of the dimolibdenum in situ method for determining the AC of 1,3-diols only. 70,71 However, until now no reports in the literature described the utilization of the in situ methodology for 1,3-amino alcohols. This fact motivated us to undertake this task.…”