In this work, we consider the generalized quantum electrodynamics proposed by Podolsky in Heisenberg picture via Källén methodology. We investigate the effects of higher-order derivatives to understand the qualitative and quantitative aspects of vacuum polarization. In addition, the most general structure of induced current and polarization tensor that emerge naturally by a perturbative scheme “à la” Källén is also obtained. Afterward, we discuss the physical implication of charge renormalization in the perspective of unitary and stable Podolsky theory.