Chiral separations by complexation with proteins in capillary zone electrophoresis

Chiral separation by chromatographic and electromigration techniques. A Review

“…Fungal cellulase [418] and cellobiohydrolase I (CBH I) [64,[419][420][421] showed remarkable chiral recognition ability for b-blockers.…”

Enantiomeric Separations in Capillary Electrophoresis Using 18-Crown-6-tetracarboxylic Acid (18C6H4) as Buffer Additive

“…Some reports discuss the applicability of dual-cyclodextrin systems, in which charged and uncharged cyclodextrins are mixed [14,15]. Proteins like human serum albumin [16], ovomucoid [17], avidin [18], etc., have been used, but their application range is somewhat limited, on the one hand, because of their high UVabsorbance and, on the other hand, because of adsorption on the capillary wall. Prevention of the latter could be established by coating the capillary wall.…”

Enantiomeric separations of dansyl amino acids using the macrocyclic antibiotic A35512B as a chiral selector in capillary electrophoresis

“…This approach allows for a great capacity of chiral separations encompassing a variety of chiral compounds by using additives such as cyclodextrins [6,7], crown ethers [8,9], carbohydrates [10], proteins [11,12], enantioselective metal complexes [13], and macrocyclic antibiotics [14±36]. In particular, several macrocyclic antibiotics such as rifamycins [14,17], vancomycin [15], ristocetin [16], teicoplanin [18], actaplanin A [20], A82846B [25,36], and LY333328 [32] have been shown to be successful in achieving enantioseparations by CE [14±18, 20,25,26,36], as well as in thin-layer chromatography (TLC) [27,28] and high performance liquid chromatography (HPLC) [29±35].…”