Chiral separation of halogenated amino acids by ligand-exchange capillary electrophoresis

Koidl, Julia; Hödl, Heike; Schmid, Martin G.; Pantcheva, Svetlana; Pajpanova, Tamara

doi:10.1002/elps.200500130

Cited by 17 publications

(8 citation statements)

References 41 publications

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“…The enantioseparation of halogenated amino acids was achieved via complexation with copper(II) and amino acids/ amino acid derivatives (L-4-hydroxyproline, L-histidine, N-(2-hydroxypropyl)-L-4-hydroxyproline and N-(2-hydroxyoctyl)-L-4-hydroxyproline) [161]. The derivatized versions of L-4-hydroxyproline provided much better resolution, at lower concentrations, than either native L-4-hydroxyproline or L-histidine.…”

Section: Ligand Exchangementioning

confidence: 99%

Review of aqueous chiral electrokinetic chromatography (EKC) with an emphasis on chiral microemulsion EKC

Kahle

Foley

2007

Electrophoresis

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Review of aqueous chiral electrokinetic chromatography (EKC) with an emphasis on chiral microemulsion EKCThe separation of enantiomers using electrokinetic chromatography (EKC) with chiral microemulsions is comprehensively reviewed through December 1, 2006. Aqueous chiral EKC separations based on other pseudostationary phases such as micelles and vesicles or on other chiral selectors such as CDs, crown ethers, glycopeptides, ligand exchange moeities are also reviewed from both mechanistic and applications perspective for the period of

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Section: Ligand Exchangementioning

confidence: 99%

Review of aqueous chiral electrokinetic chromatography (EKC) with an emphasis on chiral microemulsion EKC

Kahle

Foley

2007

Electrophoresis

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“…Besides improved enantioselectivity for amino acids these selectors showed also chiral recognition abitlity for ß-methyl amino acids [8] halogenated aromatic amino acids [29] and dipeptides [30]. Furthermore, with these selectors also drugs with amino alcohol structure such as sympathomimetics and ß-blockers were resolved [30,31].…”

Section: Capillary Zone Electrophoresismentioning

confidence: 97%

Chiral Separation by Ligand Exchange

Gbitz¹,

Schmid²

2006

Chiral Separation Techniques

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The principle of chiral ligand-exchange, introduced by Davankov, has become a widely used technique for chiral separation in both chromatography and in electromigration techniques. This simple technique makes use of the formation of mixed metal chelate complexes between a chiral selector and both enantiomers of an analyte. In HPLC, the chiral selector can be either bonded to the stationary phase or added to the mobile phase. In CE the chiral selector is simply added to the electrolyte. A relatively new approach represents CEC, where capillaries contain a chiral stationary phase. More than thousand papers appeared in the field of chiral ligand-exchange. To cite all papers would require several books.The present article gives an overview of both milestones and our activities on chiral separation using the principle of ligand-exchange. Recent advances in chip technology for chiral separations and new approaches regarding improvement of detection sensitivity are mentioned.Keywords: ligand-exchange; chiral selectors; chemically bonded phases; dynamically coated phases; monolithic phases; HPLC; capillary electrophoresis; capillary electro chromatography ХИРАЛНИ РАЗДВОЈУВАЊА СО ИЗМЕНА НА ЛИГАНДИПринципот на измена на лиганди, воведен од Даванков, стана широко користена техника за хирални раздвојувања и во хроматографските и во електромиграциските техники. Оваа едноставна техника го користи образувањето на мешани металoхелатни комплекси помеѓу хирален селектор и обата енантиомерa на аналитот. Во високоефикасната течна хроматографија (HPLC) хиралниот селектор може да биде врзан на стационарната фаза или додаден во мобилната фаза. Во капиларната електрофореза (CE) хиралниот селектор едноставно се додава во електролитот. Капиларната електрохроматографија (CEC) претставува релативно нов пристап, каде што капиларите содржат хирална стационарна фаза. Објавени се повеќе од илјада трудови од областа на хирални раздвојувања со измена на лиганди и потребни би биле повеќе книги за сите тие да се соберат.Во овој труд е даден преглед на главните развојни точки и на нашата работа на хирални разделувања со употреба на принципот на измена на лиганди. Освен тоа, наведени се и последните достигнувања на чип-технологијата за хирални раздвојувања и новите пристапи поврзани со подобрување на осетливоста на детекцијата.Клучни зборови: измена на лиганди; хирални селектори; хемиски врзани фази; динамички нанесени фази; монолитни фази; HPLC; капиларна електрофореза; капиларна електрохроматографија MJCCA9 -576

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“…5. Koidl et al published a ligand-exchange CE method for the purity check of halogenated AAs [96]. After testing several different chiral selectors the system including N-(2-hydroxyoctyl)-L-4-hydroxyproline in form of its copper complex allowed the baseline separation of eight chiral halogenated AAs.…”

Section: Chiral Separations Of Organic Acidsmentioning

confidence: 99%

Determination of organic acids by CE and CEC methods

Klampfl

2007

Electrophoresis

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A comprehensive overview of the analysis of low-molecular-mass organic acids employing electromigration methods in the capillary format is given. This review includes papers published since 2003 and can be seen as an update of the review paper published by Galli et al. in 2003. Tables included in this review contain application papers describing the determination of organic acids from a variety of fields like the analysis of food and beverages, environmental samples, samples from clinical origin, and from natural products.

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Chiral separation of halogenated amino acids by ligand-exchange capillary electrophoresis

Cited by 17 publications

References 41 publications

Review of aqueous chiral electrokinetic chromatography (EKC) with an emphasis on chiral microemulsion EKC

Review of aqueous chiral electrokinetic chromatography (EKC) with an emphasis on chiral microemulsion EKC

Chiral Separation by Ligand Exchange

Determination of organic acids by CE and CEC methods

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