Chiral separation of basic drugs by capillary electrophoresis with carboxymethylcyclodextrins

(S)-(+)-2-Octanol as a Chiral Oil Core for the Microemulsion Electrokinetic Chromatographic Separation of Chiral Basic Drugs

“…Assuming that the anionic microemulsion aggregate behaves similarly to anionic micells, the partition coefficient (K) is calculated as 24 where t0 is the migration time of the electroosmotic flow (EOF)…”

“…With a negative K value, therefore, the separation and/or chiral recognition mechanisms could preferentially take place outside the droplet. 24 In this experiment, the pH of the system was adjusted by using 0.1 M phosphoric acid and 0.1 M sodium hydroxide. The obtained result is shown in Fig.…”

“…24,28 Consequently, the effect of the (S)-(+)-2-octanol concentration in the microemulsion system 1073 ANALYTICAL SCIENCES SEPTEMBER 2007, VOL. 23 on the resolution and the partition coefficient was studied (Fig.…”

Enantiomeric Separation of Basic Drugs with Partially Filled Serum Albumin as Chiral Selector in Capillary Electrophoresis

“…[9][10][11] Among these methods, CE has become one of the most powerful methods because of its high separation efficiency, rapid analysis ability and low reagent consumption. A great number of selectors have been successfully applied to the chiral separation of CE, including cyclodextrins and their derivatives, [12][13][14] macrocyclic antibiotics, 15 polysaccharides, 16 chiral surfactants. 17 Besides, proteins have shown special chiral recognition ability of a variety of guests.…”

Enantiomer Separation of Miconazole by Capillary Electrophoresis with Dual Cyclodextrin Systems

“…Cyclodextrins have been used extensively as chiral selectors in CE, which has proved to be an effective technique for enantioseparation. [1][2][3][4][5][6] Two different methods have been used to expand the usefulness of CDs as chiral selectors for CE. The first has been to use only one kind of different neutral and charged derivatives of CDs.…”