Chiral Selector with Multiple Hydrogen-Bonding Sites in a Macrocyclic Cavity

Ema, Tadashi; Tanida, Daisuke; Sugita, Kyoko; Sakai, Takashi; Miyazawa, Ken Ichiro; Ohnishi, Akira

doi:10.1021/ol800940j

Cited by 32 publications

(23 citation statements)

References 24 publications

(20 reference statements)

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“…As has been eluded to throughout this review,asignificant part of this interesti sd riven by the highly promising medicinal properties of macrocycles. [10] However,i ti sa lso important to recognise their importance in many other scientific fields;a pplications of functionalised macrocyclesi nc atalysis, [101] materials science, [102] chiral sensing, [103] self-assembly [104] and nanotechnology [105] are all well established. Much of the groundbreaking supramolecular chemistry,t hat has become so important in recenty ears, also very often relies on the construction of carefully designed macrocyclic scaffolds.…”

Section: Discussionmentioning

confidence: 99%

Ring‐Expansion Reactions in the Synthesis of Macrocycles and Medium‐Sized Rings

Donald

Unsworth

2017

Chemistry A European J

215

108

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Functionalised macrocycles and medium-sized rings have applications in a number of scientific fields, ranging from medicinal chemistry and supramolecular chemistry, to catalysis and nanotechnology. However, their value in these areas can be undermined by a simple, but important limitation: large ring systems are very often difficult to make. Traditional end-to-end cyclisation reactions of long linear precursors are typically unpredictable and impractical processes, mainly due to unfavourable enthalpic and entropic factors. Most published methods to make large rings focus on minimising the damage inflicted by performing the difficult cyclisation step; in contrast, ring-expansion reactions enable it to be avoided altogether. In this Review article, it is highlighted how "growing" rings from existing cyclic systems via ring expansion can expedite the efficient, practical and scalable synthesis of macrocycles and medium-sized rings.

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Section: Discussionmentioning

confidence: 99%

Ring‐Expansion Reactions in the Synthesis of Macrocycles and Medium‐Sized Rings

Donald

Unsworth

2017

Chemistry A European J

215

108

View full text Add to dashboard Cite

show abstract

“…[7] Основным же подходом явля-ется пошаговый синтез. [2,8,9] Известны примеры синтеза макроциклических олигоанилинов, [5,7] олигопириди-нов, [1,8] олигопирролов, [10][11][12] олиготиофенов, [2,4,5] олиго-карбазолов. [3] Олигохиноксалиновые или олигоиндоли-зиновые макроциклы не получены.…”

Section: Introductionunclassified

Synthesis, Electrochemical and Mass Spectrometric Properties of the Macrocycles with One, Two and Four 3,3´-Biindolizine Redox-Active Fragments on the 3-(Indolizin-2-yl)quinoxalin-2-one Platform

Калинин¹,

Rakov²,

Latypova³

et al. 2016

MHC

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“…These polymers have high chemical stability and excellent solubility in organic solvents such as CHCl 3 and DMF. Furthermore, we developed aromatic polyketones containing optically active macrocycles [9][10][11][12][13] composed of 1,1¢-binaphthyl-2,2¢-dioxy units. 14,15 These macrocycle-bearing polymers have adequate thermal and optical properties and solubility for use in engineering applications.…”

Section: Introductionmentioning

confidence: 99%