Chiral resolution of cationic piperazine derivatives by capillary electrophoresis using sulfated β‐cyclodextrin
Navid Niaei,
Soodabeh Hassanpour,
Jan Petr
Abstract:This research focuses on the development and validation of a capillary electrophoresis (CE) method for the chiral separation of three H1‐antihistamine drugs chlorcyclizine, norchlorcyclizine, and neobenodine using sulfated β‐cyclodextrin (S‐β‐CD) as the chiral selector. The study explores various factors influencing the separation efficiency, including CD concentration, organic modifier content, voltage application, and buffer pH. Optimal conditions were identified as a 100 mM phosphate buffer (pH 6.0) with 34… Show more
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