“…In this context, cocrystallization has been shown to be a particularly powerful and diverse tool, with several methodologies successfully introduced in the last decade. 6 Springuel et al set the stage introducing chiral resolution through enantiospecific cocrystallization (Scheme 1, eqn (4)), focusing on resolving etiracetam using S -mandelic acid. 7 Only the cocrystal with the S -enantiomer of the target forms, which emphasizes the difference with respect to diastereomeric salt resolution.…”