Chiral Recognition of Tyrosine Enantiomers Based on Decreased Resonance Scattering Signals With Silver Nanoparticles as Optical Sensor

Abstract

A novel chiral sensing platform, employing silver nanoparticles capped with N-acetyl-L-cysteine (NALC-Ag NPs), was utilized for the discrimination of L-tyrosine and D-tyrosine. This nanosensor, which could be used as an optical sensing unit and chiral probe, was characterized by transmission electron microscopy (TEM) and resonance Rayleigh scattering (RRS) spectroscopy. After the proposed sensing platform interacted with L-tyrosine and D-tyrosine, a decreased resonance scattering signal was only obtained from L-tyrosine. This phenomenon offered a useful assay for the selectivity and determination of L-tyrosine with the RRS method. The linear range and detection limit of L-tyrosine were 0.2838-20.0 µg⋅mL(-1) and 0.0860 µg⋅mL(-1) , respectively. In addition, experimental factors such as acidity, interaction time, and the concentration of enantiomers were investigated with regard to the effect on enantioselective interaction.

Chiral recognition of the carnitine enantiomers using rhodamine B as a resonance Rayleigh scattering probe

“…According to "three interaction" (three-point interaction) theory, considering the factor of stereo, space, and rotation, at least three forces should be fit to effectively identify the two enantiomers. 36,37 Nowadays, chiral cognition is playing vital roles with discovery of chiral chemicals in the environment. "Three interaction" theory was gradually accepted to apply to environmental chiral analysis.…”

Ion-Pair Spectrophotometry in Pharmaceutical and Biomedical Analysis: Challenges and Perspectives

“…Starting with the 2000s, a series of studies underlined the utility of the method in the assay of pharmaceuticals as ion pairs with organic dyes [79][80][81] or using a counterion attached to nanoparticles [82,83] but also for unravelling of their interaction mechanisms with macromolecules of biological interest (transport proteins, DNA) [84][85][86]. Recent studies have highlighted the potential of this technique to elucidate the action mechanisms of pharmaceutical substances at the molecular level: the mechanism of interaction of oridonin (natural substance with anticancer effect) with DNA macromolecule was revealed [87]; also, the molecular mechanism by which quercetol affects the bioavailability of propranolol was explained [88].…”