Chiral recognition of a 3D chiral nanoporous metal–organic framework

Zhang, Mei; Pu, Zi-Jie; Chen, Xinglian; Gong, Xiaoli; Zhu, Ai‐Xin; Yuan, Li‐Ming

doi:10.1039/c3cc41966e

Cited by 115 publications

(61 citation statements)

References 48 publications

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“…Spherical shape and narrow particle size distribution are the two key factors for a good HPLC stationary phase. Very recently, Zhang et al 68 present a chiral MOF with an average particle size of 5 μm for the HPLC separation of alcohol, ketone, flavone, phenol, base, and amide racemates. Ten racemates were well-separated on a 25-cm long MOF column with excellent selectivity.…”

Section: Mofs For Normal-phase Hplcmentioning

confidence: 99%

Metal‐Organic Frameworks: Application to Analytical Chemistry

Chang

Yan

2014

Encyclopedia of Inorganic and Bioinorganic Chemistry

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Metal‐organic frameworks (MOFs) are an emerging class of porous materials. Owing to a number of remarkable properties, MOFs are now widely explored as advanced materials for diverse applications. Recently, great progress has been made for the applications of MOFs in analytical chemistry. This chapter focuses on the research of the analytical applications of MOFs and highlights the ability of MOFs in all the important aspects of modern analytical chemistry including sampling, solid‐phase extraction, solid‐phase microextraction, gas chromatographic separation, and liquid chromatographic separation.

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Section: Mofs For Normal-phase Hplcmentioning

confidence: 99%

Metal‐Organic Frameworks: Application to Analytical Chemistry

Chang

Yan

2014

Encyclopedia of Inorganic and Bioinorganic Chemistry

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“…HPLC is an effective technology for enantiomers separation. There are many materials for chiral HPLC, such as cellulose, cyclodextrin and MOF type chiral stationary phase (CSP) . At present, cellulose tris‐(3, 5‐dimethylphenylcarbamate) CSP is the most widely available and studied .…”

Section: Introductionmentioning

confidence: 99%

Cellulose type chiral stationary phase based on reduced graphene oxide@silica gel for the enantiomer separation of chiral compounds

Zhu

et al. 2018

Chirality

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The graphene oxide (GO) was covalently coupled to the surfaces of silica gel (SiO ) microspheres by amide bond to get the graphene oxide@silica gel (GO@SiO ). Then, the GO@SiO was reduced with hydrazine to the reduced graphene oxide@silica gel (rGO@SiO ), and the cellulose derivatives were physically coated on the surfaces of rGO@SiO to prepare a chiral stationary phase (CSP) for high performance liquid chromatography. Under the optimum experimental conditions, eight benzene-enriched enantiomers were separated completely, and the resolution of trans-stilbene oxide perfectly reached 4.83. Compared with the blank column of non-bonded rGO, the separation performance is better on the new CSP, which is due to the existence of rGO to produce special retention interaction with analytes, such as π-π stacking, hydrophobic effect, π-π electron-donor-acceptor interaction, and hydrogen bonding. Therefore, the obtained CSP shows special selectivity for benzene-enriched enantiomers, improves separation selectivity and efficiency, and rGO plays a synergistic effect with cellulose derivatives on enantioseparation.

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“…[1][2][3][4][5][6][7][8][9] Particularly, a series of MOFs have been explored for analytical applications because of their diverse structures and unusual properties. To date, there are only a few studies on Chiral MOFs that are used as chiral stationary phases (CSPs) for separation of racemic compounds in liquid chromatography (LC) [41][42][43][44] and high-resolution gas chromatography (GC). 33 Chirality plays important roles in chemistry and biology, and biological evolution is absolutely dependent on the occurrence of chiral recognition and catalysis.…”

Section: Introductionmentioning

confidence: 99%

Chiral 3D Open‐Framework Material Ni(D‐cam)(H₂O)₂ Used as GC Stationary Phase

et al. 2013

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Metal-organic frameworks (MOFs) have been explored for analytical applications because of their outstanding properties such as high surface areas, flexibility and specific structure features, especially for chromatography application in recent years. In this work, a chiral MOF Ni(D-cam)(H2O)2 with unusual integration of molecular chirality, absolute helicity, and 3-D intrinsic chiral net was chosen as stationary phase to prepare Ni(D-cam)(H2O)2-coated open tubular columns for high-resolution gas chromatographic (GC) separation. Two fused-silica open tubular columns with different inner diameters and lengths, including column A (30 m × 250 µm i.d.) and column B (2 m × 75 µm i.d.), were prepared via a dynamic coating method. The chromatographic properties of the two columns were investigated using n-dodecane as the analyte at 120 °C. The number of theoretical plates (plates/m) of the two metal-organic framework (MOF) columns was 1300 and 2750, respectively. The racemates, isomer and linear alkanes mixture were used as analytes for evaluating the separation properties of Ni(D-cam)(H2O)2-coated open tubular columns. The results showed that the columns offered good separations of isomer and linear alkanes mixture, especially racemates.

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Chiral recognition of a 3D chiral nanoporous metal–organic framework

Cited by 115 publications

References 48 publications

Metal‐Organic Frameworks: Application to Analytical Chemistry

Metal‐Organic Frameworks: Application to Analytical Chemistry

Cellulose type chiral stationary phase based on reduced graphene oxide@silica gel for the enantiomer separation of chiral compounds

Chiral 3D Open‐Framework Material Ni(D‐cam)(H₂O)₂ Used as GC Stationary Phase

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Chiral recognition of a 3D chiral nanoporous metal–organic framework

Cited by 115 publications

References 48 publications

Metal‐Organic Frameworks: Application to Analytical Chemistry

Metal‐Organic Frameworks: Application to Analytical Chemistry

Cellulose type chiral stationary phase based on reduced graphene oxide@silica gel for the enantiomer separation of chiral compounds

Chiral 3D Open‐Framework Material Ni(D‐cam)(H2O)2 Used as GC Stationary Phase

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Chiral 3D Open‐Framework Material Ni(D‐cam)(H₂O)₂ Used as GC Stationary Phase