Chiral Plasmonic Nanoparticle Assisted Raman Enantioselective Recognition

Sun, Xueping; Kong, Huanjun; Zhou, Qinghai; Tsunega, Seiji; Liu, Xinling; Yang, Haifeng; Jin, Ren‐Hua

doi:10.1021/acs.analchem.0c01311

Cited by 27 publications

(26 citation statements)

References 29 publications

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“…303 Sun et al used ''classical'' Raman spectroscopy with chiral gold nanoparticles to detect specific cystine enantiomers. 307 In another study, the surface of a gold grate was functionalized with enantiopure helicene molecules, leading to different SERS signals when it was exposed to L-or D-dihydroxyphenylalanine. 308 Similarly, Liu et al described a chiral plasmonic surface consisting of helical gold fibers which displayed selective SERS factors for different enantiomers.…”

Section: Sensingmentioning

confidence: 99%

Chiral plasmonic nanostructures: recent advances in their synthesis and applications

Pauly

2022

Mater. Adv.

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Section: Sensingmentioning

confidence: 99%

Chiral plasmonic nanostructures: recent advances in their synthesis and applications

Pauly

2022

Mater. Adv.

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“…Adsorbing on S-and R-Au NPs detached from chiral silica, analyte Cys having the same handedness as the Au NPs shows stronger Raman scattering signals (correlated with molecular vibrations) than its enantiomeric counterpart, and the difference is more than three folds. [65] This is so-called SERS-chiral anisotropy (or SERS-ChA), which has been universally adapted to differentiate 100 pairs of commercially available enantiomers using helically twisting-like Au nanofibers (Figure 3C-F). [66] The anisotropic g-factor of SERS-ChA is defined as g SERS-ChA = 2(I S − I R )/(I S + I R ), where I S and I R are the SERS intensities of S-and R-enantiomers grafting on chiral Au nanofibers (Figure 3G,H).…”

Section: Enantiodifferentiationmentioning

confidence: 99%

Recent Advances in Inorganic Chiral Nanomaterials

et al. 2021

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handedness or LH) and d-sugars (only having right handedness or RH) with unknown reason. Such biological homochirality essentially governs asymmetric biochemical reactions with diverse physiological effects, and plays a paramount role in disease therapeutics and pharmaceutical production. [1] When bulk materials are shrunk to the nanometer scale, that is, the formation of nanomaterials or generally called nanoparticles (or NPs) that possess high surface areas and restrictly confine electron movement to remarkably induce a series of compelling chemical, catalytic, optical, plasmonic, (opto)electronic, magnetic, and mechanical properties. [2] Due to these unique properties, inorganic NPs have been developed to function as multifunctional platforms for biomedical applications (or bioapplications) in drug delivery, bioimaging, disease diagnosis, screening, and therapeutic treatments. [3] The homochirality-determined asymmetic biochemical activities and processes intrincially demand the fabrication of inorganic chiral nanomaterials, whose biofunctions fundamentally depend on the asymmetric interactions at nano-bio interfaces. [4] However, most inorganic compounds thermodynamically have achiral crystal structures, and metallic crystals usually have cubic or hexagonal symmetries. [5] Chiral driving forces are indispensably applied to impose chirality onto inorganic NPs, which have been reviewed previously. [6][7][8] Chiral driving forces include chirality transfer from chiral ligands, [9][10][11] chiral templates [12] (such as DNA, [13] proteins, [14] peptides, [15] cellulose nanocrystals, [16] liquid crystals modified with chiral ligands, [17] lipidic nanoribbons, [18] chiral mesoporous silica, [19] nanohelices [20,21] ), circularly polarized light (CPL), [22] spatially chiral arrangement using lithography techniques, [23] helical magnetic fields, [24] orbital angular momentum, [25] macroscopic asymmetric gradients of biaxial strain fields, [26] and macroscopic shear forces. [27,28] A pair of chiral objects are designated as enantiomorphs, and especially a pair of chiral molecules are called enantiomers. It is of fundamental importance to differentiate an enantiomorph from its stereoisomer (i.e., enantiodifferentiation or enantiodiscrimination), mainly through monitoring differential interactions with other chiral objects. The most compelling property of inorganic chiral NPs is optical activity (OA, or the chiroptical effect), denoting the differential interactions with LH and RH CPL (or LCP and RCP conventionally used). Chiral nanomaterials have the linear OA characterized with circular dichroism (CD, denoting the differential absorption) [29] Inorganic nanoparticles offer a multifunctional platform for biomedical applications in drug delivery, biosensing, bioimaging, disease diagnosis, screening, and therapies. Homochirality prevalently exists in biological systems composed of asymmetric biochemical activities and processes, so biomedical applications essentially favor the usage of inorganic chiral nanomaterials...

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“…Furthermore, Ag NPs synthesized on SiO 2 /PDA were isolated after the removal of SiO 2 by a HF (aq) solution [Figure 10A] to obtain PDA/Ag [58] . Interestingly, D-(or L-) PDA/Ag also exhibits chiral discrimination toward tyrosine (Tyr) enantiomers [Figure 10D and E].…”

Section: Raman Enantioselective Recognition Assisted By Chiral Sio 2 -Derived Nanomaterialsmentioning

confidence: 99%

“…(E) Relative values of I 828 for tyrosine after mixing with D-, L-, A-and DL-PDA/Ag. This figure is used with permission from the American Chemical Society[58] . NPs: Nanoparticles; PDA: polydopamine.communication among organics, inorganics and light.…”

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confidence: 99%

A versatile messenger for chirality communication: asymmetric silica framework

Liu¹,

Jin²

2021

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Asymmetric tetrahedral carbon is the basic structural unit of many organic compounds in life and its molecular chirality plays a key role in regulating biological functions. Silica (SiO2) is highly earth abundant and its basic unit is also the tetrahedral form of SiO4. However, much less attention has been paid to the molecular-scale chirality of SiO2 frameworks with repeating SiO4 units because it is challenging to enantioselectively control the molecular structures of SiO2. Research into the chiral molecular structures of SiO2 deserves to be a significant topic for understanding widespread chiral phenomena and for exploring the chiral properties hidden in inorganic matter. This review highlights the asymmetric synthesis strategies that endow SiO2 with chirality transferred from asymmetric carbon at the molecular scale. The chirality transfer ability of SiO2 is also demonstrated for the construction of various inorganic and/or organic chiral materials with a wide range of applications in asymmetric synthesis, circularly polarized luminescence and Raman scattering-based chiral recognition.

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Chiral Plasmonic Nanoparticle Assisted Raman Enantioselective Recognition

Cited by 27 publications

References 29 publications

Chiral plasmonic nanostructures: recent advances in their synthesis and applications

Chiral plasmonic nanostructures: recent advances in their synthesis and applications

Recent Advances in Inorganic Chiral Nanomaterials

A versatile messenger for chirality communication: asymmetric silica framework

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