Chiral pharmacokinetics of ibuprofen enantiomers in Chinese preterm neonates with patent ductus arteriosus using a validated UHPLC-MS/MS method

Xiao, Dan; Ying, Jiang; Zhang, Mengyu; Di, Xiangjie; Fu, Lisha; Jiang, Chengchuan; Lai, Zhuoli; Ge, Yating; Ji, S. F.; Zhang, Yuming; Li, Zheng; Wang, Zhenlei; Gong, Fang

doi:10.1016/j.jchromb.2023.123765

Cited by 3 publications

(2 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The chromatographic separation of the enantiomers of IBP was achieved using a Lux® 3 μm Cellulose‐3 column with specific mobile phase compositions, and the separation was completed within 6 min at a flow rate of 0.2 mL/min 25 . The UPLC separation utilized an isocratic elution with a mobile phase consisting of formic acid and water, as well as acetonitrile and methanol.…”

Section: Methods For Stereoselective Analysis Of Ibuprofenmentioning

confidence: 99%

See 1 more Smart Citation

Enantioselective separation and determination of ibuprofen: Stereoselective pharmacokinetics, pharmacodynamics and analytical methods

Vashistha,

Kumar,

Yadav

et al. 2024

Chirality

View full text Add to dashboard Cite

Ibuprofen (IBP), the 29th most prescribed drug in the United States in 2019, is a widely used nonsteroidal anti‐inflammatory drug (NSAID) comprising two enantiomers, (R)‐IBP and (S)‐IBP, collectively known as (RS)‐IBP. This critical review examines analytical techniques for the enantioselective separation and determination of IBP enantiomers, crucial for pharmaceutical and clinical applications. The review focuses on state‐of‐the‐art methods, including chromatographic techniques including high‐performance liquid chromatography, gas chromatography, liquid chromatography–tandem mass spectrometry, and some other techniques. This review addresses pharmacokinetics, pharmacology, and side effects of each enantiomer, ensuring safe drug usage. By consolidating diverse analytical methods and their applicability in different matrices, this review serves as a valuable resource for researchers, analysts, and practitioners in pharmaceutical analysis, pharmacology, and clinical studies.

show abstract

Section: Methods For Stereoselective Analysis Of Ibuprofenmentioning

confidence: 99%

“…Xiao et al investigated the chiral pharmacokinetics of IBP enantiomers in Chinese premature infants with persistent patent ductus arteriosus (PDA) 25 . They investigated the pharmacokinetics of IBP enantiomers in nine preterm infants with PDA.…”

Section: Stereochemical Aspects Of Ibpmentioning

confidence: 99%

Enantioselective separation and determination of ibuprofen: Stereoselective pharmacokinetics, pharmacodynamics and analytical methods

Vashistha,

Kumar,

Yadav

et al. 2024

Chirality

View full text Add to dashboard Cite

show abstract

Determination of Ibuprofen Enantiomers in Mouse Blood Using Liquid Chromatography–Tandem Mass Spectrometry and Its Application to a Pharmacokinetic Study

Li,

Yang

et al. 2024

Chirality

View full text Add to dashboard Cite

The aim of this study was to establish a simple, fast, and sensitive method with liquid chromatography–tandem mass spectrometry (LC–MS/MS) for simultaneously determining ibuprofen enantiomers using mouse blood in very small volumes. LC–MS/MS equipped with an electrospray ionization (ESI) source was used in negative ion mode and multiple‐reaction monitoring mode. Enantiomer chromatographic separation was carried out on a Lux® 5 μm Cellulose‐3 (250 × 4.6 mm, 5 μm) column at a flow rate of 0.6 mL/min. Samples were pretreated by extracting only 5 μL of blood with 40 μL of acetonitrile (containing 1.3% formic acid) so that a concentration‐time profile could be completed using a single mouse. 2‐(4‐Propylphenyl) propanoic acid was used as an internal standard. Standard curves for each enantiomer were linear from 0.04 to 80.00 μg/mL, demonstrating a lower limit of quantitation (LLOQ) than all previously reported methods. This method was completely validated and successfully executed to investigate the pharmacokinetics of ibuprofen enantiomers after intravenous administration of racemic ibuprofen, (S)‐(+)‐ibuprofen, and (R)‐(−)‐ibuprofen in Kunming mice, respectively. The results showed that the pharmacokinetic profiles of the (R)‐(−)‐ibuprofen and (S)‐(+)‐ibuprofen were significantly different, indicating the unidirectional inversion of R‐(−)‐ibuprofen to (S)‐(+)‐ibuprofen.

show abstract

Recent developments in the high-throughput separation of biologically active chiral compounds via high performance liquid chromatography

De Luca,

Felletti,

Franchina

et al. 2024

Journal of Pharmaceutical and Biomedical Analysis

View full text Add to dashboard Cite

Chiral pharmacokinetics of ibuprofen enantiomers in Chinese preterm neonates with patent ductus arteriosus using a validated UHPLC-MS/MS method

Cited by 3 publications

References 39 publications

Enantioselective separation and determination of ibuprofen: Stereoselective pharmacokinetics, pharmacodynamics and analytical methods

Enantioselective separation and determination of ibuprofen: Stereoselective pharmacokinetics, pharmacodynamics and analytical methods

Determination of Ibuprofen Enantiomers in Mouse Blood Using Liquid Chromatography–Tandem Mass Spectrometry and Its Application to a Pharmacokinetic Study

Recent developments in the high-throughput separation of biologically active chiral compounds via high performance liquid chromatography

Contact Info

Product

Resources

About