Topological superfluid is an exotic state of quantum matter that possesses a nodeless superfluid gap in the bulk and Andreev edge modes at the boundary of a finite system. Here, we study a multi-orbital superfluid driven by an attractive s-wave interaction in a rotating optical lattice. Interestingly, we find that the rotation induces the inter-orbital hybridization and drives the system into topological orbital superfluid in accordance with intrinsically chiral d-wave pairing characteristics. Thanks to the conservation of spin, the topological orbital superfluid supports four rather than two chiral Andreev edge modes at the boundary of the lattice. Moreover, we find that the intrinsic harmonic confining potential forms a circular spatial barrier which accumulates atoms and supports a mass current under the injection of small angular momentum as an external driving force. This feature provides an experimentally detectable phenomenon to verify the topological orbital superfluid with chiral d-wave order in a rotating optical lattice. Recent experimental realizations of multi-orbital systems with ultra-cold atoms [1-4] have promoted the theoretical studies of high orbital physics in optical lattices, where a series of exotic quantum states have been proposed [5][6][7][8][9][10][11] . Among them, one of the remarkable characteristics is that the orbital hybridization can play the same role as spin-orbital couplings or artificial gauge fields which are the key ingredients needed to drive topologically insulating or superconducting states [12,13]. Therefore, topologically nontrivial many-body states can be implemented in multi-orbital systems in the absence of spin-orbital coupling. Several methods exist to induce orbital hybridization in the context of cold-atom systems, including the many-body interaction effect [5], lattice shaking [14][15][16][17], and local rotation [18]. The relevant quantum states including topological semimetal [5] and topological band insulators [10,15,20,21] have been proposed.Recently, the superfluid of bosons with chiral odd-frequency orders, i.e., p+ip-wave and f+if-wave, have been experimentally realized in multi-orbital cold-atom systems [2,22,23]. For fermions, however, it is still a big challenge to realize superfluid states with chiral odd-frequency orders because the atom loss is strong near the Feshbach resonance in high-frequency channels [24]. Theoretically, thanks to the Rashba spin-orbital couplings, the topological superfluids of fermions with chiral odd-frequency orders have been proposed to emerge in the s-wave channel of the Feshbach resonance [25][26][27][28]. In comparison with the well-studied chiral odd-frequency superfluids of fermions, the superfluids of fermions with chiral even-frequency orders are rarely studied, and only some candidate materials are proposed to have the chiral even-frequency orders due to the OPEN ACCESS RECEIVED