Chiral metal surfaces for enantioselective processes

Shukla, Nisha; Gellman, Andrew J.

doi:10.1038/s41563-020-0734-4

Cited by 62 publications

(63 citation statements)

References 71 publications

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“…These results indicate the potential of the bare metal surface as an effective platform for chirality detection. By manipulating chiral planes with various strategies, [52][53][54] one would achieve metal-based sensing systems with different enantioselectivity.The practical applications of pure metal-based chiral sensors could further explore for constructing novel systems capable of both chiral discrimination and separation.…”

Section: Discussionmentioning

confidence: 99%

Chiral Recognition on Bare Gold Surfaces by Quartz Crystal Microbalance

et al. 2021

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Quartz crystal microbalance (QCM) is one of the powerful tools for the studies of molecular recognition and chiral discrimination. Its efficiency mainly relies on the design of the functional sensitive layer on the electrode surface. However,t he organic sensitive layer may easily cause dissipation of oscillation or detachmentand weaken the signal transfer during the molecular recognition processes.I nt his work, we reveal for the first time that the bare metal surface without the organic selector layer has the capability for chiral recognition in the QCM system. During the adsorption of various chiral amino acids,r elatively higher selectivity of D-enantiomers on gold (Au) surface was shown by the QCM detection. Based on analyses of the surface crystalline structure and density functional theory calculations,wedemonstrate that the chiral nature of Au surface playsanimportant role in the selective binding of specific D-amino acids.These results may open new insights on chiral detection by QCM system. It will also promote the construction of novel chiral sensing systems with both efficient detection and separation capability.

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Section: Discussionmentioning

confidence: 99%

Chiral Recognition on Bare Gold Surfaces by Quartz Crystal Microbalance

et al. 2021

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“…There are many different strategies to prepare chiral inorganics now, 3,107 such as template growth, glancing angle deposition, chiral biomineralization, and chiral imprinting, and so forth. Different strategies can be used in different material systems.…”

Section: Growth Methodsmentioning

confidence: 99%

“…There is another kind of chirality in inorganic materials called surface chirality. 3 In fcc metals, high-index facets with Miller indices of h ≠ k ≠ l ≠ k and h × k × l ≠ 0 are chiral. 23 Such high-index facets can be seen as the combination of (111), (110), and (100) terraces, and the arrangement of these terraces can be used to determine the handedness of the surface ( Figure 1C3).…”

Section: Features Of Chiral Compoundsmentioning

confidence: 99%

“…Chiral form Asymmetric sp 3 promising in new technological solutions in many fields, such as biosensing, chiral catalysis, chiral resolution, biomedical imaging, information technologies like quantum computing, and so forth. 1 Coupling chiroptical properties with other physical properties would be easy due to the virtue of inorganics, which could offer new perspectives on material science as well.…”

Section: Organics Inorganicsmentioning

confidence: 99%

“…Chiral molecules are found important in life science, agrochemicals, pharmaceutical industries, biosensing, display materials, and so forth. [1][2][3][4][5] Chirality stems from a structure lacking symmetry elements of inversion symmetry and mirror-plane, which makes the structure not superimposable with its mirror image. Without these two kinds of symmetries, any structure is chiral, besides conventional chiral organics or spiral inorganic structures.…”

Section: Introductionmentioning

confidence: 99%

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Chirality communications between inorganic and organic compounds

Cölfen

2021

SmartMat

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Chirality communications between inorganic and organic compounds bridge the gap between different materials. The transfer is mainly realized by material hybridization andasymmetric synthesis, while the recognition is usually carried out in the form of enantioselective adsorption of organics on inorganics. The transfer and recognition can enlarge the number of chiral materials, which may lead to new applications in many fields.

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Asymmetric Elimination Reaction on Chiral Metal Surfaces

et al. 2021

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The production of enantiopure materials and molecules is of uttermost relevance in research and industry in numerous contexts, ranging from nonlinear optics to asymmetric synthesis. In the context of the latter, dehalogenation, which is an essential reaction step for a broad class of chemical reactions, is investigated; specifically, dehalogenation of prochiral 5‐bromo‐7‐methylbenz(a)anthracene (BMA) on prototypical, chiral, intermetallic PdGa{111} surfaces under ultrahigh vacuum conditions. Asymmetric halogen elimination is demonstrated by combining temperature‐programmed X‐ray photoelectron spectroscopy, scanning probe microscopy, and density functional theory. On the PdGa{111} surfaces, the difference in debromination temperatures for the two BMA surface enantiomers amounts up to an unprecedented 46 K. The significant dependence of the dehalogenation temperature of the BMA surface enantiomers on the atomic termination of the PdGa{111} surfaces implies that the ensemble effect is pronounced in this reaction step. These findings evidence enantiospecific control and hence promote intrinsically chiral crystals for asymmetric on‐surface synthesis.

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Chiral metal surfaces for enantioselective processes

Cited by 62 publications

References 71 publications

Chiral Recognition on Bare Gold Surfaces by Quartz Crystal Microbalance

Chiral Recognition on Bare Gold Surfaces by Quartz Crystal Microbalance

Chirality communications between inorganic and organic compounds

Asymmetric Elimination Reaction on Chiral Metal Surfaces

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