Chiral Metal–Organic Frameworks for High-Resolution Gas Chromatographic Separations

Abstract

Chiral metal-organic framework coated open tubular columns are used in the high-resolution gas chromatographic separation of chiral compounds. The columns have excellent selectivity and also possess good recognition ability toward a wide range of organic compounds such as alkanes, alcohols, and isomers.

Engineering chiral porous metal-organic frameworks for enantioselective adsorption and separation

“…Chiral MOF catalysts with uniform active sites for enantioselective reactions have been developed based on functionalized chiral molecular (pre)catalysts [21][22][23][24][25][26][27][28][29][30] . In a handful of latest studies, the resolution of enantiomers (racemic alcohols and sulphoxides) with chiral MOFs via chromatography [31][32][33][34] , crystallization [35][36][37][38][39][40] and membrane 41,42 has been reported, but only few exhibit good chiral separation performance.…”

Recent advances in solid-phase sorbents for sample preparation prior to chromatographic analysis

“…Moreover, the promising MOFs, which offer a variety of topologies, porous networks, high surface areas, nanoscale porosity, tunable pore sizes, in-pore functions, and outsurface modification, have potential for the applications of catalysis [55], separation [54,56], gas storage [57] and drug delivery [58].…”

Homochiral metal-organic framework [Zn2(d-Cam)2(4,4′-bpy)]nfor high-resolution gas chromatographic separations

“…In our previous work, we reported three chiral MOFs used as CSPs for high-resolution GC separation of organic compounds, including [{Cu(sala)} n ] [37], InH(D-C 10 H 14 O 4 ) 2 [38], and Co(D-Cam) 1/2 (bdc) 1/2 (tmdpy) [39]. These MOFs chiral columns have excellent recognition ability toward Grob's test mixture, alkanes, alcohols, and isomers, especially for racemates.…”

“…To date, a large number of chiral MOFs have been synthesized [23][24][25][26][27][28][29][30][31][32][33], which can be suitable as chiral stationary phases (CSPs) because of its excellent chiral recognition ability and thermal and mechanical stability [34,35]. However, only a few chiral MOFs have been used as CSPs in gas chromatography (GC) for separation of racemic compounds [36][37][38][39].…”