Chiral metal-organic framework [Co2(d-cam)2(TMDPy)]@SiO2 core-shell microspheres for HPLC separation

Recent progress in the development of chiral stationary phases for high‐performance liquid chromatography

“…The results indicated that the preparation of MOF@SiO 2 core-shell composites can improve the chromatographic separation performance of MOFs. Subsequently, our group prepared another MOF@SiO 2 coreshell material ([Co 2 (D-cam) 2 (TMDPy)]@SiO 2 ), where Dcam and TMDPy represent D-(+)-camphoric acid and 4,4'-trimethylenedipyridine, respectively, for chiral separation by HPLC [201]. The core-shell material was obtained by growing a chiral MOF [Co 2 (D-cam) 2 (TMDPy)] on 3aminopropylated silica microspheres using a method similar to that mentioned above.…”

A chiral metal‐organic framework core‐shell microspheres composite for high‐performance liquid chromatography enantioseparation

“…That is to say, the eddy diffusion term A of the van Deemter equation can be significantly reduced by using more homogeneous packed beds, which will dramatically improve the column efficiency and shorten the analysis time. Therefore, the morphology, uniformity, and particle size distribution of the as-synthesized porous framework materials have a remarkable impact on the eddy diffusion in the chromatographic separation [19][20]. The preparation of MOF@SiO 2 core-shell spherical composite with narrow size distribution combining the excellent separation ability of MOFs with the perfect packing property of SiO 2 microspheres is an efficient approach to avoid the above-mentioned problems [21][22][23][24][25].…”

“…So far, a few examples of chiral MOF@SiO 2 core-shell composites as CSPs for HPLC enantioseparation. Recently, our group reported that two kinds of chiral MOF@SiO 2 core-shell composites including d-his-ZIF-8@SiO 2 [34] and [Co 2 (d-cam) 2 (TMDPy)]@SiO 2 [20] via an in-situ growth method used as CSPs for HPLC separation of racemates. These chiral MOF@SiO 2 core-shell composites packed columns exhibited high enantioselectivity and excellent chiral resolution ability toward many different kinds of enantiomers such as alcohols, amines, phenols, ketones, organic acids, organic bases, and so on.…”

Synthesis of chiral functionalized UiO-66-NH2@SiO2and use of its domain-limiting effect for separating small enantiomers

“…18–20 MOFs also exhibit advantages in the separation of small enantiomers and isomers: 21–24 the domain-limited effect of the regular micropore of an MOF can amplify the differences between the three-dimensional structures of small enantiomers. In addition, the packing of composites 25–29 consisting of SiO 2 microspheres as the support and chiral MOFs (CMOFs) as major separation zones yields lower backpressure and better separation efficiency than does pure CMOF packing. 30–34…”

“…[18][19][20] MOFs also exhibit advantages in the separation of small enantiomers and isomers: [21][22][23][24] the domain-limited effect of the regular micropore of an MOF can amplify the differences between the three-dimensional structures of small enantiomers. In addition, the packing of composites [25][26][27][28][29] consisting of SiO 2 microspheres as the support and chiral MOFs (CMOFs) as major separation zones yields lower backpressure and better separation efficiency than does pure CMOF packing. [30][31][32][33][34] In the current work, two highly stable CMOF@SiO 2 composites, namely UiO-66-DATA@SiO 2 (A) and UiO-66-DBTA@SiO 2 (B), were prepared for the separation of small enantiomers, for the first time to the best of our knowledge, by carrying out a direct chiral modification of the non-chiral UiO-66-NH 2 @SiO 2 composites.…”