Chiral gold clusters functionalized two-dimensional nanoparticle films to regulate the adhesion and differentiation of stem cells

Kang, Xue; Wang, Yuan; Cai, Xiaolu; Hua, Yuejin; Shao, Zi-Hui; Chen, Xiaoyuan; Zhao, Xia; Zang, Shuang‐Quan

doi:10.1016/j.jcis.2022.06.070

Cited by 7 publications

(6 citation statements)

References 38 publications

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“…In one study, chiral gold nanoclusters ( l / d -AuNC) were loaded on two-dimensional gold nanoparticle films ( l / d -film), which were based on AuNPs with a particle size of about 50 nm, forming chiral films ( l / d -film) with diverse CD spectra. 78 The mouse BMSCs on the d -film displayed higher cell density and larger spreading area, and more differentiation into osteoblasts and less differentiation into adipocytes compared with their counterparts on the l -film (Fig. 7).…”

Section: Potential Targets For Regulating Osteogenesis and Adipogenes...mentioning

confidence: 93%

“…In one study, chiral gold nanoclusters (L/D-AuNC) were loaded on twodimensional gold nanoparticle films (L/D-film), which were based on AuNPs with a particle size of about 50 nm, forming chiral films (L/D-film) with diverse CD spectra. 78 The mouse Fig. 4 Many factors were reported to influence the characteristic of gold nanoparticles and further exert an effect on osteogenesis, adipogenesis and osteoclasis induced by gold nanoparticles, thus affecting bone homeostasis.…”

Section: Surface Chemistry and Surface Topographymentioning

confidence: 99%

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Gold nanoparticles: promising biomaterials for osteogenic/adipogenic regulation in bone repair

Qiao

Wen

et al. 2023

J. Mater. Chem. B

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Section: Potential Targets For Regulating Osteogenesis and Adipogenes...mentioning

confidence: 93%

Section: Surface Chemistry and Surface Topographymentioning

confidence: 99%

Gold nanoparticles: promising biomaterials for osteogenic/adipogenic regulation in bone repair

Qiao

Wen

et al. 2023

J. Mater. Chem. B

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“…It is found that the stereospecific interactions of the chiral ligands with biological systems can improve biocompatibility and influence cell behavior. 41 D-/L-GNCs, two types of chiral gold nanoclusters, have been synthesized. Cationic D-GNCs caused less damage to red blood cells (RBCs) compared to L-GNCs.…”

Section: ■ Nanocomposite Based On Auncsmentioning

confidence: 99%

“…In addition, chiral AuNCs have been developed. It is found that the stereospecific interactions of the chiral ligands with biological systems can improve biocompatibility and influence cell behavior …”

Section: Microcomposites Based On Auncsmentioning

confidence: 99%

Photofunctional Gold Nanocluster Composites for Bioapplications

Cong,

Liu,

Zhang

et al. 2024

ACS Appl. Bio Mater.

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Gold nanoclusters (AuNCs), with customized structures and diverse optical properties, are promising optical materials. Constructing composite systems by the assembly and incorporation of AuNCs can utilize their optical properties to achieve diagnostic and therapeutic applications in the biological field. Therefore, the exploration of the assembly behaviors of AuNCs and the enhancement of their performance has attracted widespread interest. In this review, we introduce multiple interactions and assembly modes that are prevalent in nanocomposites and microcomposites based on AuNCs. Then, the functions of AuNC composites for bioapplications are demonstrated in detail. These composite systems have inherited and enhanced the inherent optical performances of the AuNCs to meet diverse requirements for biological sensing and optical treatments. Finally, we discuss the prospects of AuNC composites and highlight the challenges and opportunities in biomedical applications.

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“…In addition, nanoparticles have become new targets for chiral effect research due to their surface effect and amplification effect. Zang et al synthesized an AuNP-loaded L/D-AuNC-based nanomaterial that was formed and used for the differentiation study of MSCs [44]. MSCs on D membranes have higher cell density and spread area than L membranes.…”

Section: Chiral Effects On Stem Cell Differentiationmentioning

confidence: 99%

Interface Chirality: From Biological Effects to Biomedical Applications

Guo

Wang

et al. 2023

Molecules

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Chiral surface is a critical mediator that significantly impacts interaction with biological systems on regulating cell behavior. To better understand how the properties of interfacial Chirality affect cell behavior and address the limitations of chiral materials for biomedical applications, in this review, we mainly focus on the recent developments of chiral bio-interfaces for the controllable and accurate guidance of chiral biomedical phenomena. In particular, we will discuss how cells or organisms sense and respond to the chiral stimulus, as well as the chirality mediating cell fate, tissue repair, and organism immune response will be reviewed. In addition, the biological applications of chirality, such as drug delivery, antibacterial, antivirus and antitumor activities, and biological signal detection, will also be reviewed. Finally, the challenges of chiral bio-interfaces for controlling biological response and the further application of interface chirality materials for biomedical will be discussed.

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Chiral gold clusters functionalized two-dimensional nanoparticle films to regulate the adhesion and differentiation of stem cells

Cited by 7 publications

References 38 publications

Gold nanoparticles: promising biomaterials for osteogenic/adipogenic regulation in bone repair

Gold nanoparticles: promising biomaterials for osteogenic/adipogenic regulation in bone repair

Photofunctional Gold Nanocluster Composites for Bioapplications

Interface Chirality: From Biological Effects to Biomedical Applications

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