Chiral Drugs and the Associated Asymmetric Synthesis

Enantiomeric pairs reveal that key medicinal chemistry parameters vary more than simple physical property based models can explain

“…This qualitative expectation is frequently found to be true and enantiomers of certain drugs are known to have different efficacy and toxicity properties. [1][2][3] Many of the key issues concerning the selection between single isomers and racemates as potential drugs were discussed at a symposium in 1982 and on many occasions since. [4][5][6] In particular, stereoisomers may bind to their target receptors differently, 5,7 be metabolized differently, 8 and distribute differently.…”