Chiral discrimination of <scp>l</scp>-DOPA <i>via</i><scp>l</scp>/<scp>d</scp>-tryptophan decorated carbon quantum dots

Rezaei, Aram; Hamad, Mohammed Ahmed; Adibi, Hadi; Zheng, Huajun; Qadir, Khdir Hamza

doi:10.1039/d3ma00757j

Cited by 3 publications

(3 citation statements)

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“…For interference study, fluorescence responses [(I-I 0 )/ I 0 ] of the Fe 2 + @cys@CuNC towards L-DOPA in presence of interfering neurotransmitters and biomolecules was conducted and results are given in Figure 6b. Here, L-DOPA was added to Nitrogen sulphur graphene quantum dots Fluorescence 7.8 nM [41] L/D-tryptophan decorated carbon quantum dots Fluorescence 11.2 nM [22] Ferrous ions incorporated copper nanoclusters (a) UV-Visible absorption spectra of cys@CuNC, Fe 2 + @cys@CuNC and L-DOPA@Fe 2 + @cys@CuNC ([L-DOPA]: 0.06 mM to 1.31 mM); (b) TCSPC decay profile of cys@CuNC, Fe 2 + @cys@CuNC and L-DOPA@Fe 2 + @cys@CuNC; (c) Normalized and merged excitation spectrum of cys@CuNCs, emission spectrum of cys@CuNCs and absorbance spectrum of Fe 2 + .…”

Section: Selectivity and Interference Studiesmentioning

confidence: 99%

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Ferrous Ions Modulated Copper Nanocluster as a Fluorescent and Colorimetric Switch for the Detection of L–DOPA

Varghese,

Chandran,

Madanan

et al. 2024

ChemistrySelect

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L‐3,4‐dihydroxyphenylalanine (levodopa or L–DOPA) a precursor of neurotransmitter dopamine, has been universally prescribed as a gold standard for treatment of Parkinson's Disease (PD). However, direct administration of L–DOPA has risky adverse effects which makes it challenging in the treatment of PD. Hence developing simple detection platform for sensing of L–DOPA is significant. In this work, we have developed cysteine stabilized copper nanocluster quenched with Fe2+ (Fe2+@cys@CuNC) and used as both fluorescent and colorimetric probe for detection of L–DOPA. L–DOPA attributed a fluorescence quenching effect on developed probe. Fe2+@cys@CuNC detected L–DOPA within a linear range from 0.06 mM to 1.31 mM with a low limit of detection (LoD) of 6.57 nM. The probe also exhibited high selectivity for L–DOPA over other biomolecules and neurotransmitters. Furthermore, the capability of this probe was validated by sensing L–DOPA from human serum with excellent recovery rates of 85.75 % to 115.07 %. A low‐cost paper strip‐based portable detection platform was also developed for visual detection of L–DOPA.

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Section: Selectivity and Interference Studiesmentioning

confidence: 99%

“…[21] Chiral detection of L-DOPA using L/D tryptophan decorated carbon dots was developed by Rezaei et al in 2024. [22] Thus fluorescence and colorimetric based detection strategy has garnered significant attention for L-DOPA detection.…”

Section: Introductionmentioning

confidence: 99%

Ferrous Ions Modulated Copper Nanocluster as a Fluorescent and Colorimetric Switch for the Detection of L–DOPA

Varghese,

Chandran,

Madanan

et al. 2024

ChemistrySelect

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“…CQDs were functionalized with an amino acid, which is the building block of proteins and peptides, which consists of chemical and physical properties with the presence of positive and negative charges with a hydrophobic nature along with the aromatic functional group. [21,22,23] These functional moieties play a key role in molecular interactions. [24] In particular, we have prepared CQDs by hydrothermal methods using L-tryptophan and tartaric acid (coded as CQD-TA-TRYP).…”

Section: Introductionmentioning

confidence: 99%

Hydrothermal Synthesis of Tartaric Acid Functionalized Amino Acid CQD for Sensing of Hg²⁺ and Fe³⁺ Ions in Aqueous Medium

Zalmi,

Khobrekar,

Jadhav

et al. 2024

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Carbon quantum dots (CQDs) are a type of carbon‐based nanoparticles that are typically smaller than 10 nanometres in size. In this study, L‐tryptophan‐mediated CQDs were synthesized using the hydrothermal carbonization (HTC) technique, which is known for its non‐toxic, environmentally friendly, and cost‐effective nature. The synthesized carbon quntum dot was successfully characterized. The HR‐TEM analysis clearly revealed the formation of specific aggregates with a size distribution ranging from 3.0 to 5.1 nm. These L‐tryptophan‐mediated CQDs exhibited remarkable emission behaviour, displaying strong and stable blue fluorescence. Moreover, they were utilized as a sensor for the sensitive detection of Fe3+ and Hg2+ ions in an aqueous solution, employing a fluorescence quenching mechanism. The limit of detection for Fe3+ sensing was determined to be 1.2×10−5 M, while for Hg2+ sensing, it was found to be 1.9×10−5 M. The sensing of Fe3+ and Hg2+ ions was also confirmed through visual eye detection, as a significant color change of the CQDs was observed. Additionally, a competitive study was conducted to verify the selectivity of the L‐tryptophan‐mediated CQDs towards Fe3+ and Hg2+ metal ions.

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Selective and sensitive CQD-based sensing platform for Cu2+ detection in Wilson’s disease

Zarei,

Rezaei,

Shahlaei

et al. 2024

Sci Rep

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Excessive Cu2+ intake can cause neurological disorders (e.g. Wilson’s disease) and adversely affect the gastrointestinal, liver, and kidney organs. The presence of Cu2+ is strongly linked to the emergence and progression of Wilson's disease (WD), and accurately measuring the amount of copper is a crucial step in diagnosing WD at an early stage in a clinical setting. In this work, CQDs were fabricated through a facile technique as a novel fluorescence-based sensing platform for detecting Cu(II) in aqueous solutions, and in the serum samples of healthy and affected individuals by WD. The CQDs interact with Cu(II) ions to produce Turn-on and Turn-off states at nano-molar and micro-molar levels, respectively, with LODs of 0.001 µM and 1 µM. In fact, the Cu2+ ions can act like a bridge between two CQDs by which the charge and electron transfer between the CQDs may increase, possibly can have significant effects on the spectroscopic features of the CQDs. To the best of our knowledge, this is the first reported research that can detect Cu(II) at low levels using two different complexation states, with promising results in testing serum. The potential of the sensor to detect Cu(II) was tested on serum samples from healthy and affected individuals by WD, and compared to results obtained by ICP-OES. Astonishingly, the results showed an excellent correlation between the measured Cu(II) levels using the proposed technique and ICP-OES, indicating the high potential of the fluorimetric CQD-based probe for Cu(II) detection. The accuracy, sensitivity, selectivity, high precision, accuracy, and applicability of the probe toward Cu(II) ions make it a potential diagnostic tool for Wilson's disease in a clinical setting.

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Chiral discrimination of l-DOPA vial/d-tryptophan decorated carbon quantum dots

Abstract: Chiral CQDs hold significant promise for enantioselective detection in the pharmaceutical industry.

Cited by 3 publications

References 47 publications

Ferrous Ions Modulated Copper Nanocluster as a Fluorescent and Colorimetric Switch for the Detection of L–DOPA

Ferrous Ions Modulated Copper Nanocluster as a Fluorescent and Colorimetric Switch for the Detection of L–DOPA

Hydrothermal Synthesis of Tartaric Acid Functionalized Amino Acid CQD for Sensing of Hg²⁺ and Fe³⁺ Ions in Aqueous Medium

Selective and sensitive CQD-based sensing platform for Cu2+ detection in Wilson’s disease

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Chiral discrimination of l-DOPA vial/d-tryptophan decorated carbon quantum dots

Abstract: Chiral CQDs hold significant promise for enantioselective detection in the pharmaceutical industry.

Cited by 3 publications

References 47 publications

Ferrous Ions Modulated Copper Nanocluster as a Fluorescent and Colorimetric Switch for the Detection of L–DOPA

Ferrous Ions Modulated Copper Nanocluster as a Fluorescent and Colorimetric Switch for the Detection of L–DOPA

Hydrothermal Synthesis of Tartaric Acid Functionalized Amino Acid CQD for Sensing of Hg2+ and Fe3+ Ions in Aqueous Medium

Selective and sensitive CQD-based sensing platform for Cu2+ detection in Wilson’s disease

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Product

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Hydrothermal Synthesis of Tartaric Acid Functionalized Amino Acid CQD for Sensing of Hg²⁺ and Fe³⁺ Ions in Aqueous Medium