Chiral Crystalline Sponges for the Absolute Structure Determination of Chiral Guests

Abstract

Chiral crystalline sponges with preinstalled chiral references were synthesized. On the basis of the known configurations of the chiral references, the absolute structures of guest compounds absorbed in the pores of the crystalline sponges can be reliably determined without crystallization or chemical modification.

Isolating reactive metal-based species in Metal–Organic Frameworks – viable strategies and opportunities

“…Some of the initial uses of MOFs as a crystallisation matrix have demonstrated this point with electron rich guests being organised and characterised by X-ray crystallography in the pores of crystalline sponge hosts. 34,39,[150][151][152][153][154][155] More recently, this concept has been extended to reactive metal-based species by installing a reactive cartridge into the pore network. 20 Finally, inspired by the importance of metal nanoclusters (MNCs) in catalysis, a number of reports have now shown the precise structural characterisation of MNCs.…”

An Ultrastable π–π Stacked Porous Organic Molecular Framework as a Crystalline Sponge for Rapid Molecular Structure Determination

“…[5][6][7] It can conveniently determine the structures of the organic molecules through in-situ single-crystal-to-single-crystal (SC-SC) process. The strategy perfectly solves the structure determination problem for hardly crystallized liquids and other stubborn non-crystallizing compounds, [8][9] and the absolute configuration confirmation of natural products, [10][11][12][13][14] as well as inspection of the transient intermediates in chemical reaction. [15][16] Until now, only a few cases of metal-organic frameworks (MOFs) 5,9,[17][18][19][20][21][22][23][24][25][26][27] have been proved for crystalline sponge platform.…”

Precise Assembly and Supramolecular Catalysis of Tetragonal- and Trigonal-Elongated Octahedral Coordination Containers

“…Varying the symmetry and length of organic linkers is a key factor to achieve the geometric and size modulation of well-defined nanocavity in coordination containers, thereby providing an accessible approach to regulating host-guest chemistry properties to achieve the desired applications such as selective guest recognition and catalytic reactivity. [24][25][26][27] While C 3 -symmetry tripodal ligands are well-known organic linkers for the construction of tetrahedral and octahedral coordination containers, [28][29][30][31][32] the utilization of tritopic ligands with a lower symmetry for the design of coordination containers is much less common, 33,34 presumably due to the stringent geometrical requirements for the assembly of high-symmetry polyhedral structures, even in rarer cases of severely distorted or irregular coordination polyhedral, constructed from mixed linkers of distinct sizes and shapes. Furthermore, symmetric tripodal organic linkers often occupy the faces of tetrahedral or octahedral coordination containers, likely to prevent specific guest molecules from accessing the endo cavity (where the host-guest chemistry is typically most active) and limit molecular recognition capability.…”