Chiral Building Blocks for Total Steroid Synthesis and the Use of Steroids as Chiral Building Blocks in Organic Synthesis

Synthesis of a Side Chain Alkyne Analogue of Sitosterol as a Chemical Probe for Imaging in Plant Cells

“…This aim could not be achieved through a latestage functionalization of sitosterol (2). The de novo enantioselective synthesis of complex steroids can only be achieved by means of complex multi-step procedures [27]. So, we intended to develop a synthetic approach which includes the assembly of the side chain at C-17 in a stereoselective manner, starting from an appropriately substituted steroidal precursor in the sense of a chiral pool synthesis [28,29], ideally utilizing asymmetric induction through existing stereocenters.…”

Neurosteroid enantiomers as potentially novel neurotherapeutics

“…A review by Biellmann (2003) describes synthetic methods for their preparation. More recent synthetic methods also exist ( Jastrzebska and Covey, 2022 ), but are not reviewed here.…”

Enantioselective [3 + 3] Annulation–Deoxalation Strategy for Rapid Access to δ-Oxoesters via N-Heterocyclic Carbene Catalysis

“…Asymmetric synthesis of simple, chiral building blocks, which possess important functional groups for subsequent chemical and stereochemical diversification, is a crucial task in contemporary organic synthesis . Derivatives of 1,5-dicarbonyl compounds are widely applied in creating five- or six-membered ring heterocycles and polycyclic aromatic compounds due to their versatility in conversion into various complex organic systems. , This underpins their extensive use in numerous fields, particularly in the generation of bioactive molecules.…”